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Chemical Structure| 68399-80-4 Chemical Structure| 68399-80-4
Chemical Structure| 68399-80-4

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DIPSO is a zwitterionic biological buffer with an effective pH range of 7.0-8.2. It influences the regulation of meiotic division in mouse oocytes and exhibits surface activity at a concentration of 10 mM.

4.5 *For Research Use Only! Not for Human Use. We Do Not Sell to Patients.

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Product Details of DIPSO

CAS No. :68399-80-4
Formula : C7H17NO6S
M.W : 243.28
SMILES Code : O=S(CC(O)CN(CCO)CCO)(O)=O
English Name :3-(Bis(2-hydroxyethyl)amino)-2-hydroxypropane-1-sulfonic acid
MDL No. :MFCD00038353
InChI Key :XCBLFURAFHFFJF-UHFFFAOYSA-N
Pubchem ID :100210

Safety of DIPSO

Application In Synthesis of DIPSO

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 68399-80-4 ]

[ 68399-80-4 ] Synthesis Path-Downstream   1~5

  • 2
  • [ 10025-75-9 ]
  • [ 68399-80-4 ]
  • [ 366804-89-9 ]
YieldReaction ConditionsOperation in experiment
In water Na-compd:lanthanida-salt molar ratio was 2:1, reflux for 1 h; soln. was cooled to room temp., solid was washed with hot EtOH and recrystd. from hot EtOH-H2O (1:1) mixt., dried in vac. for several h, elem. anal.;
  • 3
  • [ CAS Unavailable ]
  • [ 68399-80-4 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
In water Na-compd:lanthanida-salt molar ratio was 2:1, reflux for 1 h; soln. was cooled to room temp., solid was washed with hot EtOH and recrystd. from hot EtOH-H2O (1:1) mixt., dried in vac. for several h, elem. anal.;
  • 4
  • [ 68399-80-4 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: water 2: neat (no solvent)
  • 5
  • [ 68399-80-4 ]
  • [ 27668-52-6 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
84% Stage #1: 3-[N,N-Bis(2-hydroxyethyl)amino]-2-hydroxypropanesulfonic acid; octadecyldimethyl[3-(trimethoxysilyl)propyl]ammonium chloride In N,N-dimethyl-formamide at 145℃; Stage #2: With sodium methylate In N,N-dimethyl-formamide 8 Example 8. Synthesis of Disodium; 3-[2-[3-[heptadecyl(dimethyl)ammonio]propyl-[2-[2- hydroxyethyl-(2-hydroxy-3-sulfonato-propyl)amino]ethoxy]-[2-[2-hydroxyethyl-(2- hydroxy-3-sulfo-propyl)amino]ethoxy]silyl]oxyethyl-(2-hydroxyethyl)amino]-2-hydroxy- propane-1-sulfonate; chloride. A 1L round bottom reaction vessel was outfitted with a heating mantle, stir bar, downward condenser, receiving flask, oil bubbler, an immersion thermoprobe for the pot, and a thermoprobe for the head. The reactor was charged with 17 grams of dimethyloctadecyl[3- (trimethoxysilyl)propyl]ammonium chloride, 25g of DIPSO, and 300 mL DMF. The mixture was heated to 145 °C (pot temp) and the methanol is collected until the head temp drops and no more MeOH evolved. The reaction was then cooled and 3.7g (2 eq) NaOMe was added with stirring. The DMF was evaporated at reduced pressure to yield a semi-solid. Toluene (250ml) was added, the mixture stirred at room temp for 1 hour, and then evaporated at reduced pressure. Acetonitrile (250ml) was added, the suspension stirred at room temp for 1 hour, and then evaporated at reduced pressure. This process was repeated until DMF no long was evident by NMR. The resultant product was placed under high vacuum overnight to yield an off-white semi-solid. The solid dissolved in water but forms a precipitate after 5 hours. The NMR spectrum conformed to the expected product.
 

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