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Chemical Structure| 2610-05-1 Chemical Structure| 2610-05-1

Structure of Direct Blue 1
CAS No.: 2610-05-1

Chemical Structure| 2610-05-1

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Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles and also inhibits macrophage migration inhibitory factor (MIF) with IC50 of 0.81 μM.

Synonyms: Chicago Sky Blue 6B; C.I. 24410; NCI 9617

4.5 *For Research Use Only !

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Product Details of Direct Blue 1

CAS No. :2610-05-1
Formula : C34H24N6Na4O16S4
M.W : 992.80
SMILES Code : [Na+].[Na+].[Na+].[Na+].COC1=CC(=CC=C1\N=N\C1=C(O)C2=C(C=C1)C(=CC(=C2N)S([O-])(=O)=O)S([O-])(=O)=O)C1=CC(OC)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S([O-])(=O)=O)S([O-])(=O)=O
Synonyms :
Chicago Sky Blue 6B; C.I. 24410; NCI 9617
MDL No. :MFCD00004020
InChI Key :BPHHNXJPFPEJOF-UHFFFAOYSA-J
Pubchem ID :17460

Safety of Direct Blue 1

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H350
Precautionary Statements:P201-P202-P280-P308+P313-P405-P501

Isoform Comparison

Biological Activity

Description
Direct Blue 1, known as Chicago Sky Blue 6B, is employed to quench background autofluorescence in immunofluorescence histochemistry. It acts as a potent and competitive inhibitor of VGLUT and can block the binding of Aβ to small molecule PrP ligands. Direct Blue 1 exhibits anti-inflammatory properties[1][2][3][4][5][6].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.01mL

0.20mL

0.10mL

5.04mL

1.01mL

0.50mL

10.07mL

2.01mL

1.01mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

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