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Chemical Structure| 157341-41-8 Chemical Structure| 157341-41-8

Structure of DMP 777
CAS No.: 157341-41-8

Chemical Structure| 157341-41-8

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DMP 777 is a potent, selective, and orally active human leukocyte elastase (HLE) inhibitor.

Synonyms: L-694458

4.5 *For Research Use Only !

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Product Details of DMP 777

CAS No. :157341-41-8
Formula : C31H40N4O6
M.W : 564.67
SMILES Code : O=C(N1[C@@H](OC2=CC=C(C(N3CCN(C)CC3)=O)C=C2)C(CC)(CC)C1=O)N[C@@H](C4=CC=C(OCO5)C5=C4)CCC
Synonyms :
L-694458
MDL No. :MFCD00871548

Safety of DMP 777

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00116493 Anemia Phase 3 Completed - Pakistan ... More >> Aga Khan University Karachi, Sindh, Pakistan Less <<
NCT01327469 Infection by Trichuris Trichiu... More >>ra Less << Phase 4 Completed - Ethiopia ... More >> Jimma University Jimma, Ethiopia Less <<
NCT00080444 Vomiting Phase 3 Completed - -
NCT03278431 Hookworm Infection Phase 4 Completed - Lao People's Democratic Republ... More >>ic Nambak District Hospital Luang Prabang, Lao People's Democratic Republic, 0604 Less <<
NCT01050452 Parasitic Diseases Not Applicable Completed - Uganda ... More >> Vector Control Division Kampala, Uganda Less <<
NCT01050374 Parasitic Diseases Not Applicable Completed - Uganda ... More >> Vector Control Division Kampala, Uganda Less <<
NCT00000314 Cocaine-Related Disorders Phase 2 Completed - United States, New York ... More >> VA Medical Center Brooklyn, New York, United States, 11209 Less <<
NCT01350271 Necator Americanus Infection Phase 3 Completed - Sri Lanka ... More >> Agalawatta Plantations PLC Nivitigala, Sabragamuwa, Sri Lanka Lellopitiya Estate, Hapugastenne Plantations PLC Ratnapura, Sabragamuwa, Sri Lanka Less <<
NCT01350271 - Completed - -
NCT01379326 Ascaris Lumbricoides ... More >> Ascaris Suum Trichuris Trichiura Trichuris Vulpis Ancylostoma Duodenal Ancylostoma Caninum Ancylostoma Ceylanicum Necator Americanus Less << Phase 4 Completed - Argentina ... More >> Fundacion Huesped Buenos Aires, Argentina Australia Commonwealth Scientific and Industrial Research Organisation Brisbane, Australia Queensland Institute for Medical Research, University of Queensland Herston QLD, Australia Brazil Fundação Oswaldo Cruz Belo Horizonte, Brazil Cambodia Institut Pasteur in Cambodia, Clinical Pathology Unit Phnom Penh, Cambodia Cameroon University of Yaoundé I Yaoundé I, Cameroon Ethiopia College of Public Health and Medical Sciences, Jimma University Jimma, Ethiopia Tanzania Ivo de Carneri, Pemba Island Zanzibar, Tanzania Vietnam National Institute for Malariology, Parasitology and Entomology Hanoi, Vietnam Less <<
NCT03472573 Recurrent B Acute Lymphoblasti... More >>c Leukemia Refractory B Acute Lymphoblastic Leukemia Less << Phase 1 Recruiting November 2020 United States, Pennsylvania ... More >> Sidney Kimmel Cancer Center at Thomas Jefferson University Recruiting Philadelphia, Pennsylvania, United States, 19107 Contact: Margaret Kasner, MD    215-955-8874    margaret.kasner@jefferson.edu    Principal Investigator: Margaret Kasner, MD Less <<
NCT03245398 Hookworm Phase 4 Completed - Tanzania ... More >> Public Health Laboratory Ivo de Carneri, P.O. Box 122 Chake Chake, Pemba, Tanzania Less <<
NCT01208233 Ischemic Stroke Phase 2 Terminated(See termination rea... More >>son in detailed description.) Less << - -
NCT03628079 Cancer of the Gastrointestinal... More >> Tract Cancer of Unknown Origin Less << Phase 1 Phase 2 Recruiting June 2020 Sweden ... More >> Dept of oncology, University Hospital Recruiting Uppsala, Sweden, 75185 Less <<
NCT02201381 Cancer Overal... More >>l Survival Less << Phase 3 Recruiting October 22, 2023 United Kingdom ... More >> Care Oncology Clinic Recruiting London, United Kingdom, W1G 9PP Contact: Gregory Stoloff    +44 207 580 3266    info@careoncologyclinic.com    Contact: Robin Bannister, PhD    +44 207 153 6577    robin.bannister@seekacure.com Less <<
NCT02492334 PTSD Alcohol ... More >>Use Disorder Less << Phase 1 Phase 2 Recruiting March 2019 United States, South Carolina ... More >> Addiction Sciences Division-Medical University of South Carolina Recruiting Charleston, South Carolina, United States, 29425 Contact: Megan M Moran-Santa Maria, Ph.D.       moranm@musc.edu    Contact: Francis M Beylotte, MS    8437922522 ext Beylotte    beylott@musc.edu    Sub-Investigator: Julianne Flanagan, Ph.D.          Principal Investigator: Sudie Back, Ph.D. Less <<
NCT01837862 Pilomyxoid Astrocytoma ... More >> Pilocytic Astrocytoma Glioma, Astrocytic Optic Nerve Glioma Pleomorphic Xanthoastrocytoma Glioblastoma Multiforme Anaplastic Astrocytoma Gliosarcoma Diffuse Intrinsic Pontine Glioma DIPG Low-grade Glioma Brainstem Glioma Less << Phase 1 Phase 2 Recruiting April 2020 United States, New York ... More >> Cohen Children's Medical Center of New York Recruiting New Hyde Park, New York, United States, 11040 Contact: Mark P Atlas, MD    718-470-3460    matlas@nshs.edu    Contact: Derek R Hanson, MD    551-996-5437    DHanson@hackensackumc.org    Principal Investigator: Mark P Atlas, MD          Sub-Investigator: Derek R Hanson, MD          Sub-Investigator: Arlene Redner, MD          Sub-Investigator: Mohamad Badawi, MD          Sub-Investigator: Avery Wright, DO Less <<
NCT01208233 - Terminated(See termination rea... More >>son in detailed description.) Less << - -
NCT01450683 Prostate Cancer ... More >> Prostatic Neoplasms Castrate-resistant Prostate Cancer (CRPC) Androgen-insensitive Prostate Cancer Hormone-refractory Prostate Cancer Metastatic Disease Less << Phase 2 Terminated(Low accrual) - United States, California ... More >> Stanford University School of Medicine Stanford, California, United States, 94305 Less <<
NCT01173562 Healthy Volunteers Phase 3 Completed - Tanzania ... More >> Pemba, Tanzania Less <<
NCT01161069 Healthy Phase 1 Completed - Belgium ... More >> Pfizer Investigational Site Bruxelles, Belgium, 1070 Less <<
NCT01450683 - Terminated(Low accrual) - -
NCT02385058 Helminthiasis ... More >> Amoebiasis Less << Phase 4 Completed - Mexico ... More >> Mex, Mexico Less <<
NCT02152527 - Completed - Croatia ... More >> School of Medicine, University of Split Split, Croatia, 21000 Less <<
NCT02034162 - Completed - -
NCT02034162 Helminth Infections Phase 3 Completed - Ethiopia ... More >> Gondar, Ethiopia Jimma, Ethiopia Rwanda Kigali, Rwanda Less <<
NCT01395381 Kwashiorkor M... More >>arasmus Less << Not Applicable Withdrawn(not funded) - Malawi ... More >> St. Louis Nutrition Project Blantyre, Malawi Less <<
NCT02255461 Childhood Choroid Plexus Tumor... More >> Childhood Ependymoblastoma Childhood Grade III Meningioma Childhood High-grade Cerebellar Astrocytoma Childhood High-grade Cerebral Astrocytoma Childhood Medulloepithelioma Recurrent Childhood Anaplastic Astrocytoma Recurrent Childhood Anaplastic Oligoastrocytoma Recurrent Childhood Anaplastic Oligodendroglioma Recurrent Childhood Brain Stem Glioma Recurrent Childhood Cerebellar Astrocytoma Recurrent Childhood Cerebral Astrocytoma Recurrent Childhood Giant Cell Glioblastoma Recurrent Childhood Glioblastoma Recurrent Childhood Gliomatosis Cerebri Recurrent Childhood Gliosarcoma Recurrent Childhood Medulloblastoma Recurrent Childhood Pineoblastoma Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor Less << Phase 1 Recruiting December 31, 2018 United States, California ... More >> Childrens Hospital Los Angeles Recruiting Los Angeles, California, United States, 90027 Contact: Girish Dhall    323-361-4629    gdhall@chla.usc.edu    Principal Investigator: Girish Dhall          Lucile Packard Children Hospital Stanford University Recruiting Palo Alto, California, United States, 94304 Contact: Paul G. Fisher    650-721-5889    pfisher@stanford.edu    Principal Investigator: Paul G. Fisher          United States, District of Columbia Childrens National Medical Center Recruiting Washington, District of Columbia, United States, 20010-2970 Contact: Eugene Hwang, MD    202-476-5046    ehwang@childrensnational.org    Principal Investigator: Lindsay B Kilburn, MD          Sub-Investigator: Roger Packer, MD          Sub-Investigator: Brain Rood, MD          Sub-Investigator: Eugene Hwang, MD          United States, Illinois Lurie Childrens Hospital-Chicago Recruiting Chicago, Illinois, United States, 60614 Contact: Stewart Goldman    312-227-4874    sgoldman@luriechildrens.org    Principal Investigator: Stewart Goldman, MD          Sub-Investigator: Jason Fangusaro, MD          Sub-Investigator: Rishi Lulla, MD          Sub-Investigator: Natasha Pillay-Smiley, MD          United States, New York Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Ira Dunkel    212-639-2153    dunkeli@mskcc.org    Principal Investigator: Ira Dunkel          United States, North Carolina Duke University Medical Center Recruiting Durham, North Carolina, United States, 27710 Contact: David Van Mater, MD, PhD    919-684-3401    david.vanmater@duke.edu    Principal Investigator: David Van Mater          United States, Ohio Cincinnati Children Hospital Medical Center Recruiting Cincinnati, Ohio, United States, 45229 Contact: Maryam Fouladi    513-803-0721    maryam.fouladi@cchmc.org    Principal Investigator: Maryam Fouladi          United States, Pennsylvania Children Hospital of Pittsburgh of UPMC Recruiting Pittsburgh, Pennsylvania, United States, 15224 Contact: Ian Pollack    412-692-5881    Pollaci@chp.edu    Sub-Investigator: Ian Pollack, MD          Principal Investigator: A. Kim Ritchey, MD          United States, Tennessee St. Jude Children Research Hospital Recruiting Memphis, Tennessee, United States, 38105 Contact: Giles Robinson, MD    901-595-2907    giles.robinson@stjude.org    Principal Investigator: Zsila Sadighi, MD          Sub-Investigator: Amar Gajjar, MD          United States, Texas Texas Childrens Hospital Recruiting Houston, Texas, United States, 77030 Contact: Patricia M. Baxter, MD    832-824-4681    pabaxter@txch.org    Sub-Investigator: Murali M. Chintagumpala          Principal Investigator: Patricia Baxter          United States, Washington Seattle Children Hospital Recruiting Seattle, Washington, United States, 98105 Contact: Sarah Leary    206-987-2106    sarah.leary@seattlechildrens.org    Principal Investigator: Sarah Leary Less <<
NCT02420574 Helminthiasis Not Applicable Completed - -
NCT03539731 Healthy Subject ... More >> Intracranial Neoplasm Recurrent Glioblastoma Less << Phase 1 Recruiting April 23, 2020 United States, California ... More >> Stanford University, School of Medicine Recruiting Palo Alto, California, United States, 94304 Contact: Hari Priya M. Yerraballa    650-724-9363    yhpriya@stanford.edu    Principal Investigator: Sanjiv Gambhir Less <<
NCT01905423 - Completed - -
NCT01905423 - Completed - Indonesia ... More >> University of Indonesia, Department of Parasitology Jakarta, Java, Indonesia, 10430 Less <<
NCT01729260 Newly Diagnosed High-Grade Gli... More >>oma Less << Phase 1 Active, not recruiting September 2020 United States, Maryland ... More >> The Johs Hopkins Hospital Baltimore, Maryland, United States, 21287 Less <<
NCT01314937 Malnutrition ... More >>Intestinal Diseases, Parasitic Less << Phase 4 Completed - Peru ... More >> Asociacion Civil Selva Amazonica Iquitos, Loreto, Peru Less <<
NCT02644291 Medulloblastoma ... More >> Astrocytoma, Grade III Glioblastoma Anaplastic Astrocytoma Brain Stem Neoplasms, Malignant Oligodendroblastoma Anaplastic Oligodendroglioma Malignant Glioma Less << Phase 1 Recruiting June 2021 United States, Florida ... More >> Johns Hopkins All Children's Hospital Recruiting Saint Petersburg, Florida, United States, 33701 Contact: Stacie Stapleton, M.D.    727-767-4176    stacie.stapleton@jhmi.edu    United States, Maryland Johns Hopkins University School of Medicine Recruiting Baltimore, Maryland, United States, 21231 Contact: Tammy Scott, RN    410-614-5990    SCOTTTA@jhmi.edu    Contact: Kenneth J Cohen, MD    410-614-5055    kcohen@jhmi.edu    Principal Investigator: Kenneth J Cohen, MD Less <<
NCT03757403 Idiopathic Pruritus Ani Phase 2 Not yet recruiting January 31, 2020 United Kingdom ... More >> The Atherstone Surgery Not yet recruiting Atherstone, United Kingdom, CV9 1EU Contact: Jeanette Melrose, MD          University Hospitals Bristol NHS Foundation Trust- Location Bristol Royal Infirmary Not yet recruiting Bristol, United Kingdom, IG95LP Contact: Debbie Shipley, MD          Kings Medical Centre Buckhurst Hill, United Kingdom, IG95LP Sheepcot Medical Centre Not yet recruiting Watford, United Kingdom, WD25 7NL Contact: Alan Jackson, MD Less <<
NCT03261596 Hookworm Infections Phase 4 Withdrawn(In light of new evid... More >>ence, the decision was made by the sponsor to not proceed.) Less << December 2017 Ghana ... More >> Noguchi Memorial Institute for Medical Research - University of Ghana Legon, Accra, Ghana Less <<
NCT02051738 Healthy Phase 1 Completed - Belgium ... More >> Merksem, Belgium Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.85mL

1.77mL

0.89mL

17.71mL

3.54mL

1.77mL

References

 

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