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Chemical Structure| 4590-86-7 Chemical Structure| 4590-86-7

Structure of DOCK2-IN-1
CAS No.: 4590-86-7

Chemical Structure| 4590-86-7

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DOCK2-IN-1 is a DOCK2 inhibitor with an IC50 of 19.1 μM, which reversibly binds to the DOCK2 DHR-2 domain, inhibiting its catalytic activity and blocking lymphocyte activation and chemotaxis, suitable for immune and inflammatory research.

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Product Details of DOCK2-IN-1

CAS No. :4590-86-7
Formula : C16H11ClN2O2
M.W : 298.72
SMILES Code : O=C(C1=CC2=CC=CC=C2Cl)NN(C3=CC=CC=C3)C1=O
MDL No. :N/A

Safety of DOCK2-IN-1

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
DOCK2-IN-1, analogous to CPYPP, functions as an inhibitor targeting the DOCK2 enzyme, with an IC50 of 19.1 μM. It engages the DOCK2 DHR-2 domain reversibly, impeding its catalytic function. This inhibitor effectively halts the activation of Rac, a GTPase, by both chemokine and antigen receptors in lymphocytes, thereby substantially diminishing chemotactic responses and T cell activation[1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.35mL

0.67mL

0.33mL

16.74mL

3.35mL

1.67mL

33.48mL

6.70mL

3.35mL

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