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Chemical Structure| 693-23-2 Chemical Structure| 693-23-2
Chemical Structure| 693-23-2

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Dodecanedioic acid is a dicarboxylic acid and used as raw chemical material.

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Product Details of Dodecanedioic Acid

CAS No. :693-23-2
Formula : C12H22O4
M.W : 230.30
SMILES Code : OC(=O)CCCCCCCCCCC(O)=O
MDL No. :MFCD00002735
InChI Key :TVIDDXQYHWJXFK-UHFFFAOYSA-N
Pubchem ID :12736

Safety of Dodecanedioic Acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of Dodecanedioic Acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 693-23-2 ]

[ 693-23-2 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 623-57-4 ]
  • [ 693-23-2 ]
  • C29H53NO8 [ No CAS ]
  • 2
  • [ 623-57-4 ]
  • [ 693-23-2 ]
  • [2,3-bis-(11-carboxyundecanoyloxy)propyl]trimethylammonium iodide [ No CAS ]
  • 3
  • [ 693-23-2 ]
  • [ 15121-84-3 ]
  • 2-(1-(2-nitrophenyl)ethoxy)-12-oxododecanoic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
31% With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0℃; Synthesis of2-(1 -(2-nitrophenyl)ethoxy)-1 2-oxododecanoic acid10480] Dodecanedioic acid (6 g, 26.1 mmol), cat. DMAP, and 1-2(-nitrophenyl)ethanol (1.45 g, 8.7 mmol) were dissolved in DMF (70 mE), and the solution was cooled to 0° C. To the mixture was added 1 -Ethyl-3-(3-dimethylaminopro- pyl)carbodiimide (EDCI) (2.5 g, 13 mmol) and the reaction was stirred overnight and warmed to room temperature. The solution was taken up into EtOAc (500 mE) and washed with water, iN HC1, and sat. NH4C1 solutions. The organic layer was dried over Na2504. The volatiles were evaporated and the residue was purified on silica gel chromatography (gradient hexanes:EtOAc, 5:1 to 4:1 to 3:1 to 2:1), affording 2-(1- (2-nitrophenyl)ethoxy)-12-oxododecanoic acid as a thick oil in 31percent yield. 1H NMR (300 MHz, CDC13): oe=1.21 (br.s, 12H), 1.49-1.66 (m, 7H), 2.20-2.33 (m, 4H), 6.27 (q, 1H, J=6 Hz), 7.30-7.43 (m, 1H), 7.53-7.65 (m, 2H), 7.87 (d, 1H, J=8.2 Hz). 13C NMR (300 Hz, CDC13): oe=20.8, 21.9, 24.6, 24.7, 28.7, 29.0, 29.1, 29.3, 34.0, 34.2, 67.8, 124.3, 127.1, 128.3,133.5, 138.0, 147.7, 172.7, 177.6, 180.3.
 

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