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Chemical Structure| 18474-59-4 Chemical Structure| 18474-59-4

Structure of eIF4A3-IN-8
CAS No.: 18474-59-4

Chemical Structure| 18474-59-4

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eIF4A3-IN-8 is a selective ATP-competitive eIF4A3 inhibitor, used as a chemical probe to study the function of the exon junction complex (EJC), widely applied in cell biology and gene regulation research.

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Product Details of eIF4A3-IN-8

CAS No. :18474-59-4
Formula : C10H9NO2
M.W : 175.18
SMILES Code : O=C(C(N1)=CC2=C1C=C(C)C=C2)O
MDL No. :MFCD02664477
InChI Key :ZKGSVVHFMZASJS-UHFFFAOYSA-N
Pubchem ID :3163396

Safety of eIF4A3-IN-8

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Description
eIF4A3-IN-8 acts as a specific ATP-competitive inhibitor for the eukaryotic initiation factor 4A3 (eIF4A3), serving as an essential chemical probe for investigating the complex functions of eIF4A3 and the exon junction complex (EJC)[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

5.71mL

1.14mL

0.57mL

28.54mL

5.71mL

2.85mL

57.08mL

11.42mL

5.71mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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