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Chemical Structure| 92761-26-7 Chemical Structure| 92761-26-7
Chemical Structure| 92761-26-7

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Kang, Nam-Hee ; Park, Chang-Eon ; Kim, So-Hee ; Gwak, Eunji ; Kim, Seongsook ; Go, Min-Gyu , et al.

Abstract: Phototoxicity (or photoirritation) is defined as an acute toxic response elicited by topically or systematically administered photoreactive chemicals after the exposure of the body to environmental light. Korean Center for the Validation of Alternative Methods (KoCVAM) developed and optimized an in vitro phototoxicity test method using KeraSkinTMTMTMTMTM

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Nam-Hee Kang ; So-Hee Kim ; Joohwan Kim ;

Abstract: Phototoxicity is an acute toxic reaction induced by topical skin exposure to photoreactive chemicals followed by exposure to environmental light and thus chemicals that absorb UV are recommended to be evaluated for phototoxic potential. There are currently three internationally harmonized alternative test methods for phototoxicity. One of them is the in vitro Phototoxicity: RhE Phototoxicity test method (OECD TG498). Korean center for the Validation of Alternative Methods (KoCVAM) developed an in vitro phototoxicity test method using a KeraSkin™ reconstructed human epidermis model (KeraSkin™ Phototoxicity Assay) as a ‘me-too’ test method of OECD TG498. For the development and optimization of KeraSkin™ Phototoxicity Assay, the following test chemicals were used: 6 proficiency chemicals in OECD TG498 (3 phototoxic and 3 non-phototoxic), 6 reference chemicals in OECD Performance Standard No. 356 (excluding the proficiency test chemicals, 3 phototoxic and 3 non-phototoxic) and 13 additional chemicals (7 phototoxic and 6 non-phototoxic). Based on the test results generated from the test chemicals above, the overall predictive capacity of KeraSkin™ Phototoxicity Assay was calculated. In particular, the assay exhibited 100 % accuracy, 100 % sensitivity, and 100 % specificity. Therefore, it fulfills the requirements to be included as a ‘me-too’ test method in OECD TG498.

Keywords: Phototoxicity ; Reconstructed human epidermis (RhE) ; Alternative test ; OECD TG498 ; KoCVAM

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Product Details of Ecamsule

CAS No. :92761-26-7
Formula : C28H34O8S2
M.W : 562.69
SMILES Code : O=C1C(C2(C)C)(CS(=O)(O)=O)CCC2/C1=C/C3=CC=C(/C=C4C(C5(CS(=O)(O)=O)CCC/4C5(C)C)=O)C=C3
English Name :((1,4-Phenylenebis(methaneylylidene))bis(7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl-3-ylidene))dimethanesulfonic acid
MDL No. :MFCD09838439

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