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Chemical Structure| 2225887-26-1 Chemical Structure| 2225887-26-1

Structure of EGFR-IN-5
CAS No.: 2225887-26-1

Chemical Structure| 2225887-26-1

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EGFR-IN-5 is an inhibitor of EGFR with IC50 values of 10.4 nM, 1.1 nM, 34 nM and 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively. It could suppress EGFR phosphorylation in a dose-dependent manner in HCC827 cell line and significantly induce the apoptosis of HCC827 cells.

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Product Details of EGFR-IN-5

CAS No. :2225887-26-1
Formula : C31H38FN9O
M.W : 571.69
SMILES Code : FC1=CC=C(C=C1)NC2=NC3=C(C(N4CCC(CO)CC4)=N2)C=C(NC5=CC=C(N6CCC(N(C)C)CC6)C=N5)N=C3
MDL No. :MFCD31813637
InChI Key :DXOUQSZKEPSXBC-UHFFFAOYSA-N
Pubchem ID :134817166

Safety of EGFR-IN-5

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Related Pathways of EGFR-IN-5

RTK
JAK-STAT

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.75mL

0.35mL

0.17mL

8.75mL

1.75mL

0.87mL

17.49mL

3.50mL

1.75mL

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