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Chemical Structure| 439087-18-0 Chemical Structure| 439087-18-0

Structure of Elobixibat
CAS No.: 439087-18-0

Chemical Structure| 439087-18-0

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Elobixibat is a potent ileal bile acid transporter (IBAT) inhibitor with IC50 values of 0.53 ± 0.17 nM, 0.13 ± 0.03 nM, and 5.8 ± 1.6 nM for human IBAT, mouse IBAT, and canine IBAT.

Synonyms: A 3309; AZD 7806; AJG-533

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Product Details of Elobixibat

CAS No. :439087-18-0
Formula : C36H45N3O7S2
M.W : 695.89
SMILES Code : O=C(O)CNC([C@@H](C1=CC=CC=C1)NC(COC2=C(SC)C=C(C3=C2)N(C4=CC=CC=C4)CC(CCCC)(CCCC)CS3(=O)=O)=O)=O
Synonyms :
A 3309; AZD 7806; AJG-533
MDL No. :MFCD28386301

Safety of Elobixibat

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01069783 Dyslipidemia Phase 2 Completed - Sweden ... More >> BCRC Linköping, Sweden Less <<
NCT01895543 - Completed - -
NCT01038687 Functional Constipation Phase 2 Completed - United States, Minnesota ... More >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Less <<
NCT01895543 Chronic Idiopathic Constipatio... More >>n Less << Phase 3 Completed - -
NCT01833065 Chronic Idiopathic Constipatio... More >>n Less << Phase 3 Terminated(Terminated due to a... More >> distribution issue with the trial medication) Less << - -
NCT01827592 - Terminated(Terminated due to a... More >> distribution issue with the trial medication) Less << - -
NCT01007123 Constipation ... More >>Chronic Constipation Less << Phase 2 Completed - -
NCT01833065 - Terminated(Terminated due to a... More >> distribution issue with the trial medication) Less << - -
NCT01007123 - Completed - -
NCT02392546 Chronic Idiopathic Constipatio... More >>n Less << Phase 2 Withdrawn(Business reasons) April 2016 United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States Less <<
NCT01827592 Chronic Idiopathic Constipatio... More >>n Less << Phase 3 Terminated(Terminated due to a... More >> distribution issue with the trial medication) Less << - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.44mL

0.29mL

0.14mL

7.19mL

1.44mL

0.72mL

14.37mL

2.87mL

1.44mL

 

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