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Chemical Structure| 793719-01-4 Chemical Structure| 793719-01-4

Structure of EN450
CAS No.: 793719-01-4

Chemical Structure| 793719-01-4

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EN450 is a covalent molecular glue degrader targeting NF-κB. It interacts with the mutant C111 in the E2 ubiquitin-conjugating enzyme UBE2D. EN450 induces the formation of a ternary complex between UBE2D and NFKB1. EN450 exerts antiproliferative effects through a cullin E3 ligase and proteasome-dependent mechanism.

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Product Details of EN450

CAS No. :793719-01-4
Formula : C11H13ClN2O3S
M.W : 288.75
SMILES Code : C=CC(NC1=CC(S(=O)(N(C)C)=O)=CC=C1Cl)=O

Safety of EN450

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of EN450

pyroptosis

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.46mL

0.69mL

0.35mL

17.32mL

3.46mL

1.73mL

34.63mL

6.93mL

3.46mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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