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Chemical Structure| 550999-75-2 Chemical Structure| 550999-75-2

Structure of Encenicline
CAS No.: 550999-75-2

Chemical Structure| 550999-75-2

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EVP-6124 is a partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) and shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs.

Synonyms: EVP-6124

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Product Details of Encenicline

CAS No. :550999-75-2
Formula : C16H17ClN2OS
M.W : 320.84
SMILES Code : O=C(C1=CC2=CC=CC(Cl)=C2S1)N[C@H]3CN4CCC3CC4
Synonyms :
EVP-6124
MDL No. :MFCD23381267

Safety of Encenicline

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
SH-SY5Y cells 0.1-10 μM 24 hours Promoted Nrf2 nuclear translocation and upregulated Nrf2 downstream gene expression, thereby protecting cells from oxidative stress damage PMC7283419

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Rhesus macaques Age-related cognitive impairment model Intramuscular injection 0.033-0.3 mg/kg Each dose was administered 3 times, tested 30 minutes after administration To evaluate the pro-cognitive effects of Encenicline on age-related cognitive disorders, results showed that doses of 0.1 and 0.3 mg/kg significantly improved task accuracy in cognitively impaired monkeys PMC8286428

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02327182 Alzheimer's Disease Phase 3 Terminated(This study was term... More >>inated due to the benefit-risk balance of MT-4666.) Less << - Japan ... More >> Investigational site Osaka, Kansai, Japan Less <<
NCT01073228 Alzheimer's Disease ... More >> Central Nervous System Diseases Cognition Less << Phase 2 Completed - -
NCT00766363 Alzheimer's Disease ... More >> Central Nervous System Diseases Less << Phase 1 Completed - United States, California ... More >> Pacific Research Network, Inc. San Diego, California, United States, 92103 United States, Florida MD Clinical Hallandale Beach, Florida, United States, 33009 United States, New Jersey Comprehensive Clinical Research Berlin, New Jersey, United States, 08009 Global Medical Institutes, LLC Princeton, New Jersey, United States, 08540 Less <<
NCT01556763 Schizophrenia ... More >> Schizoaffective Disorder Central Nervous System Diseases Less << Phase 1 Completed - United States, Kansas ... More >> Clinical Research Institute Wichita, Kansas, United States, 67211 Less <<
NCT00968851 Schizophrenia ... More >> Central Nervous System Diseases Cognition Less << Phase 2 Completed - -
NCT01716975 Schizophrenia ... More >> Impaired Cognition Less << Phase 3 Completed - -
NCT01556763 - Completed - -
NCT01480232 Nicotine Dependence ... More >> Smoking Cessation Less << Phase 2 Terminated(Study has been put ... More >>on clinical hold by FDA) Less << - United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 Less <<
NCT00766363 - Completed - -
NCT01969123 Alzheimer's Disease ... More >> Dementia Less << Phase 3 Terminated(Study has been susp... More >>ended due to clinical hold.) Less << January 2017 -
NCT01487135 Healthy Subjects ... More >> Cardiac Repolarization Less << Phase 1 Completed - -
NCT01714661 Schizophrenia ... More >> Impaired Cognition Less << Phase 3 Completed - -
NCT02004392 Alzheimer's Disease|Dementia PHASE3 TERMINATED 2025-08-17 Phoenix, Arizona, United State... More >>s|Tucson, Arizona, United States|Little Rock, Arkansas, United States|Costa Mesa, California, United States|Culver City, California, United States|Encino, California, United States|Glendale, California, United States|Long Beach, California, United States|Los Alamitos, California, United States|Orange, California, United States|Redding, California, United States|San Diego, California, United States|New Haven, Connecticut, United States|Norwich, Connecticut, United States|Atlantis, Florida, United States|Brooksville, Florida, United States|Delray Beach, Florida, United States|Fort Myers, Florida, United States|Hallandale Beach, Florida, United States|Hialeah, Florida, United States|Jacksonville, Florida, United States|Leesburg, Florida, United States|Miami, Florida, United States|Orlando, Florida, United States|Sunrise, Florida, United States|West Palm Beach, Florida, United States|Columbus, Georgia, United States|Park Ridge, Illinois, United States|Wichita, Kansas, United States|Baton Rouge, Louisiana, United States|Bangor, Maine, United States|Newton, Massachusetts, United States|Plymouth, Massachusetts, United States|Flowood, Mississippi, United States|Hattiesburg, Mississippi, United States|Creve Coeur, Missouri, United States|Princeton, New Jersey, United States|Springfield, New Jersey, United States|Albuquerque, New Mexico, United States|Brooklyn, New York, United States|Cedarhurst, New York, United States|Latham, New York, United States|Staten Island, New York, United States|Charlotte, North Carolina, United States|Wilmington, North Carolina, United States|Oklahoma City, Oklahoma, United States|Portland, Oregon, United States|Norristown, Pennsylvania, United States|Plains, Pennsylvania, United States|East Providence, Rhode Island, United States|San Antonio, Texas, United States|Salt Lake City, Utah, United States|Bennington, Vermont, United States|Charlottesville, Virginia, United States|Williamsburg, Virginia, United States|Richland, Washington, United States|Geelong, Victoria, Australia|Leuven, Belgium|Kelowna, British Columbia, Canada|Halifax, Nova Scotia, Canada|Chatham, Ontario, Canada|Toronto, Ontario, Canada|Praha, Czech Republic|Rychnov nad Kneznou, Czech Republic|Milano, Lombardia, Italy|Busan, Korea, Republic of|Incheon, Korea, Republic of|Seoul, Korea, Republic of|Amsterdam, Netherlands|Bialystok, Poland|Warszawa, Poland|Johannesburg, Gauteng, South Africa|Pretoria, Gauteng, South Africa|Durban, Kwa-Zulu Natal, South Africa|Bellville, Western Cape, South Africa|George, Western Cape, South Africa|Somerset West, Western Cape, South Africa|Terrassa, Barcelona, Spain|Burgos, Spain|Madrid, Spain|Salamanca, Spain|Glasgow, United Kingdom|Isleworth, United Kingdom|Northampton, United Kingdom|Penarth, United Kingdom|Southampton, United Kingdom Less <<
NCT01969136 Alzheimer's Disease ... More >> Dementia Less << Phase 3 Terminated(Study has been susp... More >>ended due to clinical hold.) Less << January 2017 -
NCT01480232 - Terminated(Study has been put ... More >>on clinical hold by FDA) Less << - -
NCT02246075 Alzheimer's Disease|Dementia|C... More >>ognition Less << PHASE2 WITHDRAWN - Delray Beach, Florida, United ... More >>States|Albuquerque, New Mexico, United States Less <<
NCT01984723 Renal Impairment Phase 1 Completed - Czech Republic ... More >> Jankovcova 1569/2c, 17000 Praha 7, Czech Republic Hungary Rottenbiller u. 13 H-1077 Budapest, Hungary Less <<
NCT01984736 Hepatic Impairment Phase 1 Completed - Czech Republic ... More >> Jankovcova 1569/2c, 17000 Praha 7, Czech Republic Poland Ul. Seczkowa 20B/8, Warszawa, Mazowieckie, 02-793, Poland Slovakia Bardosova 2/A 83101 Bratislava, Slovakia Less <<
NCT01714713 Schizophrenia|Impaired Cogniti... More >>on Less << PHASE3 COMPLETED 2025-10-15 Little Rock, Arkansas, United ... More >>States|Anaheim, California, United States|Bellflower, California, United States|Cerritos, California, United States|Chino, California, United States|Costa Mesa, California, United States|Culver City, California, United States|Downey, California, United States|Escondido, California, United States|Garden Grove, California, United States|Glendale, California, United States|Los Angeles, California, United States|Mesa, California, United States|Norwalk, California, United States|Oakland, California, United States|Oceanside, California, United States|Orange, California, United States|Riverside, California, United States|San Diego, California, United States|San Gabriel, California, United States|Santa Ana, California, United States|Sherman Oaks, California, United States|Torrance, California, United States|Washington, District of Columbia, United States|Lauderhill, Florida, United States|Miami Springs, Florida, United States|Miami, Florida, United States|North Miami, Florida, United States|Oakland Park, Florida, United States|Orange City, Florida, United States|Orlando, Florida, United States|Atlanta, Georgia, United States|Marietta, Georgia, United States|Smyrna, Georgia, United States|Chicago, Illinois, United States|Oak Brook, Illinois, United States|Oak Park, Illinois, United States|Wichita, Kansas, United States|Lake Charles, Louisiana, United States|Shreveport, Louisiana, United States|Boston, Massachusetts, United States|Minneapolis, Minnesota, United States|Flowood, Mississippi, United States|Creve Coeur, Missouri, United States|O'Fallon, Missouri, United States|St. Charles, Missouri, United States|St. Louis, Missouri, United States|Lincoln, Nebraska, United States|Omaha, Nebraska, United States|Nashua, New Hampshire, United States|Princeton, New Jersey, United States|Albuquerque, New Mexico, United States|Cedarhurst, New York, United States|Jamaica, New York, United States|New York, New York, United States|Charlotte, North Carolina, United States|Cleveland, Ohio, United States|Shaker Hts., Ohio, United States|Oklahoma City, Oklahoma, United States|Conshohocken, Pennsylvania, United States|Jenkintown, Pennsylvania, United States|Norristown, Pennsylvania, United States|Philadelphia, Pennsylvania, United States|Phoenixville, Pennsylvania, United States|Austin, Texas, United States|Dallas, Texas, United States|Salt Lake City, Utah, United States|Bellevue, Washington, United States|Spokane, Washington, United States|La Plata, Buenos Aires, Argentina|C.a.b.a, Argentina|Mendoza, Argentina|Adelaide, South Australia, Australia|Melbourne, Victoria, Australia|Mechelen, Belgium|Calgary, Alberta, Canada|Penticton, British Columbia, Canada|Chatham, Ontario, Canada|Kingston, Ontario, Canada|Montreal, Quebec, Canada|Medellin, Antioquia, Colombia|Barranquilla, Atlantico, Colombia|Pereira, Risaralda, Colombia|Bogota D.C., Colombia|Bogota D.C, Colombia|Berlin, Germany|Dusseldorf, Germany|Leipzig, Germany|Mittweida, Germany|Stralsund, Germany|Catania, CT, Italy|Roma, RM, Italy|Milano, Italy|Mexico, DF, Mexico|Guadalajara, Jalisco, Mexico|Monterrey, Nuevo Leon, Mexico|Mexico, D.F, Mexico|San Luis Potosi, Mexico|Belchatow, Poland|Campulung, Arges, Romania|Oradea, Bihor, Romania|Cluj-Napacu, Cluj, Romania|Cluj-Napoca, Cluj, Romania|Palazu-Mare, Constanta, Romania|Targu Mures, Mures, Romania|Bucuresti, Sector 4, Romania|Talagi, Arkhangelsk region, Russian Federation|Smolensk, Smolensk Region, Russian Federation|Moscow, Russian Federation|Saint Petersburg, Russian Federation|Saint-Petersburg, Russian Federation|Stavropol, Russian Federation|Yaroslavl, Russian Federation|Singapore, Singapore|Salamanca, Castilla y Leon, Spain|Zamora, Castilla y Leon, Spain|Alcorcon, Madrid, Spain|Coslada, Madrid, Spain|Madrid, Spain|Vil. Stepanivka, Kherson, Ukraine|Dnipropetrovsk, Ukraine|Ivano-Frankivsk, Ukraine|Kharkiv, Ukraine|Kyiv, Ukraine|Lviv, Ukraine|Poltara, Ukraine|Poltava, Ukraine|Vinnytsia, Ukraine|London, United Kingdom Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.12mL

0.62mL

0.31mL

15.58mL

3.12mL

1.56mL

31.17mL

6.23mL

3.12mL

References

 

Historical Records

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