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Chemical Structure| 1608140-48-2 Chemical Structure| 1608140-48-2

Structure of endo-BCN-PEG8-NHS ester
CAS No.: 1608140-48-2

Chemical Structure| 1608140-48-2

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Product Details of [ 1608140-48-2 ]

CAS No. :1608140-48-2
Formula : C34H54N2O14
M.W : 714.80
SMILES Code : O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)OC[C@H]2[C@]3(CCC#CCC[C@@]23[H])[H]
MDL No. :MFCD31692212

Safety of [ 1608140-48-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 1608140-48-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1608140-48-2 ]

[ 1608140-48-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 6066-82-6 ]
  • [ 756526-04-2 ]
  • [ 1426827-79-3 ]
  • [ 1608140-48-2 ]
YieldReaction ConditionsOperation in experiment
60% To a solution of amino-dPEG8-acid (217 mg, 0.492 mmol) in anhydrous DMF (3 mL) were subsequently added 51 (143 mg, 0.492 mmol) and Et3N (204 tL, 1.47 mmol). The reaction mixture stirred for 3h at rt, after which EDCI.HC1 (0.88 g, 4.61 mmol) and NHS (88 mg, 0.77 mmol) were added. The resulting solution was stirred overnight at rt andpoured into 50 mL NaHCO3 (sat.) and 50 mL EtOAc. The layers were separated and the organic phase was washed with sat. NaHCO3 (50 mL) and H20 (30 mL). The organic phase was dried (Na2504), filtered and concentrated in vacuo. Gradient flash chromatography (MeCN - MeCN:H20 30:1) afforded product 60b as colorless oil (212 mg, 0.30 mmol, 60%).‘H NMR (300 IVIFIz, CDC13): (ppm) 4.13 (d, J 8.1 Hz, 2H), 3.84 (t, J 6.3 Hz, 2H),3.68-3.59 (m, 28 H), 3.54 (t, J 5.1 Hz, 2H), 3.36 (q, J= 5.4 Hz, 2H), 2.89 (t, J= 6.3Hz, 2H), 2.82 (s, 4H), 2.35-2.15 (m, 6H), 1.68-1.48 (m, 2H), 1.44-1.23 (m, 1H), 1.00-0.86 (m, 2H). LRMS (ESI+) m/z calcd for C34H54N20,4 (M+Naj = 737.8; found 737.3.
 

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