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Chemical Structure| 77671-31-9 Chemical Structure| 77671-31-9

Structure of Enoximone
CAS No.: 77671-31-9

Chemical Structure| 77671-31-9

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Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also exhibits PDE4 inhibitory effect with an IC50 of 21.1 μM for myocardial PDE4A. Enoximone has the potential for congestive heart failure research and has bronchodilatory, antiasthma and anti-inflammatory effects.

Synonyms: MDL 17043

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Product Details of Enoximone

CAS No. :77671-31-9
Formula : C12H12N2O2S
M.W : 248.30
SMILES Code : O=C1NC(C)=C(C(C2=CC=C(SC)C=C2)=O)N1
Synonyms :
MDL 17043
MDL No. :MFCD00867130
InChI Key :ZJKNESGOIKRXQY-UHFFFAOYSA-N
Pubchem ID :53708

Safety of Enoximone

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Human peripheral blood mononuclear cells (PBMCs) 10 μM 30 minutes Study the effect of milrinone on CD11b expression PMC5821178

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03772990 Cardiac Surgery ... More >> Cardiopulmonary Bypass Less << Phase 4 Not yet recruiting March 30, 2022 -
NCT01864252 Myocardial Reperfusion Injury Phase 3 Unknown February 2016 United Kingdom ... More >> The Heart Hospital, UCL Hospitals NHS Trust Recruiting London, United Kingdom, NW1 2PG Contact: Ashraf Hamarneh, MBchB,MRCP    02034479781    a.hamarneh@ucl.ac.uk    Principal Investigator: Derek M Yellon, PhD DSc FACC          Principal Investigator: Derek J Hausenloy, MD PhD FRCP          Sub-Investigator: Ashraf Hamarneh, MBchB MRCP          Sub-Investigator: Shyam Kolvekar, MS MCh FRCS          Sub-Investigator: Roger Cordery, BSc FRCA          Sub-Investigator: Vivek Sivaraman, MRCP MD FRCA Less <<
NCT00484133 Severe Sepsis ... More >> Microcirculation Less << Phase 4 Unknown - Netherlands ... More >> Onze Lieve Vrouwe Gasthuis, intensive care Recruiting Amsterdam, Netherlands, 1090 HM Contact: Rutger v Raalte, MD    0031205993007    R.vanRaalte@olvg.nl    Principal Investigator: Rutger v Raalte, MD Less <<
NCT00060840 Congestive Heart Failure Phase 2 Completed - United States, New Jersey ... More >> Newark Beth Isreal Medical Center Newark, New Jersey, United States, 07112 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Ohio University of Cincinnati Cincinnati, Ohio, United States, 45219 Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 United States, Pennsylvania Allegheny General Hospital Pittsburgh, Pennsylvania, United States, 15212 United States, Texas Baylor University Medical Center Dallas, Texas, United States, 75226 University of Texas/St. Paul Medical Center Dallas, Texas, United States, 75390 Texas Heart Institute Houston, Texas, United States, 20345 Germany Herz-und Diabeteszentrum Nordrhein-Westfalen Gergstrab, Bad Oeynhausen, Germany, 32545 Deutsches Herfzzentrum Berlin Augustenburger Platz, Berlin, Germany, 13353 United Kingdom Harefield Hospital Harefield, Middlesex, United Kingdom, UB96JH Less <<
NCT00348101 Coronary Artery Disease Phase 3 Completed - Germany ... More >> Department of Anesthesiology and Intensive Care Medicine Klinikum Ludwigshafen Ludwigshafen, Germany, 67063 Less <<
NCT02285309 - Unknown - -
NCT00051285 Heart Failure, Congestive Phase 3 Terminated - -
NCT03729011 Delirium Phase 4 Not yet recruiting January 29, 2022 -
NCT00077948 Heart Failure, Congestive Phase 3 Terminated - United States, Colorado ... More >> University of Colorado Denver, Colorado, United States, 80262 United States, Utah University of Utah Salt Lake City, Utah, United States, 84132 Less <<
NCT00060840 - Completed - -
NCT04420455 COPD Exacerbation|Enoximone|Ph... More >>osphodiesterase Inhibitor Less << PHASE4 TERMINATED 2021-12-21 M.V. Koning, Arnhem, M, Nether... More >>lands Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.03mL

0.81mL

0.40mL

20.14mL

4.03mL

2.01mL

40.27mL

8.05mL

4.03mL

References

 

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