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Chemical Structure| 2883495-35-8 Chemical Structure| 2883495-35-8

Structure of Enpp/Carbonic anhydrase-IN-1
CAS No.: 2883495-35-8

Chemical Structure| 2883495-35-8

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Enpp/Carbonic anhydrase-IN-1 is an effective inhibitor of ENPP and carbonic anhydrase with IC50 values of 1.36, 1.35, 3.00, 0.88, and 1.02 μM for NPP1, NPP2, NPP3, CA-II, and CA-IX, respectively. It demonstrates anti-proliferative activity against cancer cells while showing low cytotoxicity to normal cells, inducing apoptosis.

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Product Details of Enpp/Carbonic anhydrase-IN-1

CAS No. :2883495-35-8
Formula : C23H25NO4S
M.W : 411.51
SMILES Code : O=S(C1=CC=CC=C1)(OC2=CC=C(NC(C34CC5CC(C4)CC(C5)C3)=O)C=C2)=O
MDL No. :N/A

Safety of Enpp/Carbonic anhydrase-IN-1

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
Enpp/Carbonic anhydrase-IN-1 is a potent Enpp and carbonic anhydrase inhibitor with IC50 values of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX, respectively. This compound demonstrates significant antiproliferative efficacy against cancer cells while maintaining minimal cytotoxicity towards normal cells. Additionally, Enpp/Carbonic anhydrase-IN-1 elicits apoptosis[1].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.43mL

0.49mL

0.24mL

12.15mL

2.43mL

1.22mL

24.30mL

4.86mL

2.43mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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