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Chemical Structure| 1047659-02-8 Chemical Structure| 1047659-02-8

Structure of Entacapone sodium salt
CAS No.: 1047659-02-8

Chemical Structure| 1047659-02-8

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Entacapone sodium is a specific, potent, peripherally acting catechol-O-methyltransferase (COMT) inhibitor with IC50 of 151 nM for PD treatment.

Synonyms: Entacapone Sodium

4.5 *For Research Use Only !

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Product Details of Entacapone sodium salt

CAS No. :1047659-02-8
Formula : C14H14N3NaO5
M.W : 327.27
SMILES Code : O=C(N(CC)CC)/C(C#N)=C/C1=CC([N+]([O-])=O)=C([O-])C(O)=C1.[Na+]
Synonyms :
Entacapone Sodium
MDL No. :MFCD28346924
InChI Key :UMQUSXKIIWDDTK-OAZHBLANSA-M
Pubchem ID :78357787

Safety of Entacapone sodium salt

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P264-P270-P301+P310-P321-P330-P405-P501
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Description
Entacapone sodium salt is an effective, reversible, peripherally active, and orally administered catechol-O-methyltransferase (COMT) inhibitor. It inhibits COMT in rat brain, erythrocytes, and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone sodium salt selectively inhibits COMT over other catecholamine metabolizing enzymes such as MAO-A, MAO-B, phenolsulphotransferase M (PST-M), and PST-P, all with IC50 values greater than 50 µM, and is used in Parkinson's disease research[1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.28mL

3.06mL

1.53mL

30.56mL

6.11mL

3.06mL

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