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Structure of Epothilone B
CAS No.: 152044-54-7
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Epothilone B is a microtubule stablizer which can promote tubulin polymerization.
Synonyms: EPO 906; Patupilone; (-)-Epothilone B
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CAS No. : | 152044-54-7 |
Formula : | C27H41NO6S |
M.W : | 507.68 |
SMILES Code : | O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C[C@]3([H])O[C@]3(C)CCC[C@H](C)[C@H](O)[C@@H](C)C1=O |
Synonyms : |
EPO 906; Patupilone; (-)-Epothilone B
|
MDL No. : | MFCD02101921 |
InChI Key : | QXRSDHAAWVKZLJ-PVYNADRNSA-N |
Pubchem ID : | 448013 |
GHS Pictogram: |
![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H301-H311-H317-H331-H340-H360-H372 |
Precautionary Statements: | P201-P202-P260-P261-P264-P270-P271-P272-P280-P281-P301+P310-P302+P352-P304+P340-P308+P313-P311-P312-P314-P321-P322-P330-P333+P313-P361-P363-P403+P233-P405-P501 |
Class: | 6.1 |
UN#: | 2811 |
Packing Group: | Ⅲ |
In Vitro:
Concentration | Treated Time | Description | References |
SKOV-3 cells | 10 µM | 12 hours | Evaluate ROS responsiveness and drug release of Z-E ADCN in SKOV-3 cells | PMC11337599 |
SN neurons | 5 nM | 12 hours | To simulate ICH and investigate the effect of EpoB on microtubule stabilization | PMC5850167 |
ES-2-luc cells | 0.4 nM | 2 weeks | Evaluate the clonogenic inhibition effect of Epothilone B on ES-2-luc cells, showing a 25% inhibition rate. | PMC5722673 |
HCT15 cells | 50 µg/ml | 24 hours | To compare the apoptosis-inducing effects of UTD1 and paclitaxel in ABCB1 high-expression cells, UTD1 showed stronger apoptosis-inducing ability | PMC8016927 |
NR8383 cells | 1 nM or 5 nM | 3 or 5 days | To evaluate the effect of Epothilone B on the proliferation of NR8383 cells. Results showed that Epothilone B inhibited the division of NR8383 cells. | PMC5775408 |
Human ovarian carcinoma cell line 1A9/B10 | 5 nM | 4 days | Evaluate the cytotoxicity of Epothilone B on 1A9/B10 cells | PMC16028 |
Human ovarian carcinoma cell line 1A9/A8 | 5 nM | 4 days | Evaluate the cytotoxicity of Epothilone B on 1A9/A8 cells | PMC16028 |
Human ovarian carcinoma cell line 1A9 | 0.5 nM | 4 days | Evaluate the cytotoxicity of Epothilone B on 1A9 cells | PMC16028 |
Human ovarian carcinoma cell line 1A9 | 0.5 nM | 4 days | To select Epothilone B-resistant sublines | PMC16028 |
Epothilone B-resistant subline 1A9/A8 | 5 nM | 5 hours | To evaluate tubulin polymerization in resistant cells | PMC16028 |
DAOY | 0.19 nM (IC50) | 72 hours | To evaluate the antiproliferative and cytotoxic effects of Epothilone B on DAOY cells, showing an IC50 of 0.19 nM | PMC3158010 |
D425Med | 0.37 nM (IC50) | 72 hours | To evaluate the antiproliferative and cytotoxic effects of Epothilone B on D425Med cells, showing an IC50 of 0.37 nM | PMC3158010 |
D341Med | 0.53 nM (IC50) | 72 hours | To evaluate the antiproliferative and cytotoxic effects of Epothilone B on D341Med cells, showing an IC50 of 0.53 nM | PMC3158010 |
MEF3.8 cells | 9.3 nM (IC50) | 72 hours | To evaluate the sensitivity of MEF3.8 cells to Epothilone B, results showed that MRP7-transfected cells exhibited 3.3-fold resistance to Epothilone B. | PMC2745904 |
HEK293 cells | 0.99 nM (IC50) | 72 hours | To evaluate the sensitivity of HEK293 cells to Epothilone B, results showed that MRP7-transfected cells exhibited 5.3-6.8-fold resistance to Epothilone B. | PMC2745904 |
ES-2-luc cells | 0.427 nM (IC50) | 72 hours | Evaluate the antiproliferative effect of Epothilone B on ES-2-luc cells, showing an IC50 value of 0.427 nM, which is more potent than paclitaxel. | PMC5722673 |
HCT116 cells | 0.77 µg/ml (IC50) | 72 hours | To evaluate the direct effect of UTD1 on CRC cell proliferation, results showed UTD1 significantly inhibited proliferation of RKO and HCT116 cells | PMC8016927 |
RKO cells | 0.38 µg/ml (IC50) | 72 hours | To evaluate the direct effect of UTD1 on CRC cell proliferation, results showed UTD1 significantly inhibited proliferation of RKO and HCT116 cells | PMC8016927 |
HeLa | 67 nM | 72 hours | Measure cytotoxicity, IC50 value was 67 nmol/L | PMC5535963 |
A549 | 163 nM | 72 hours | Measure cytotoxicity, IC50 value was 163 nmol/L | PMC5535963 |
MDA-MB-231 breast cancer cells | 10 nM | 72 hours | To evaluate the cytotoxic effect of Epothilone B on MDA-MB-231 cells, showing significant reduction in cell proliferation. | PMC8624627 |
MIAPaCa-2 cells | 0 nM, 0.1 nM, 0.2 nM, 0.4 nM, 0.8 nM | Validate the inhibitory effect of Epothilone B on pancreatic cancer cell line MIAPaCa-2 | PMC10533800 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Rats | Thoracic spinal cord dorsal hemisection | Intraperitoneal injection | 0.75 mg/kg | Administered at day 1 and 15 post-injury | Reduced fibrotic scar tissue, promoted axon regeneration and improved motor function recovery | PMC4445125 |
Sprague-Dawley rats | Spinal cord injury model | Intraperitoneal injection | 0.75 mg/kg | Once at 1 day and once at 15 days post-injury | Epothilone B reduced scar formation after spinal cord injury, promoted axonal regeneration, and improved motor function. | PMC5399728 |
C57/BL6 mice | ICH model | Intraperitoneal injection | 1.5 mg/kg | Administered 2 hours after ICH surgery | EpoB alleviated nigrostriatal pathway injury and improved motor function associated with microtubule stabilization by increasing the expression of acetylated a-tubulin | PMC5850167 |
Nude mice | D425Med xenograft model | Intravenous injection | 2 mg/kg | Single dose | To evaluate the efficacy of combined treatment with Epothilone B and ionizing radiation on D425Med xenografts, showing complete tumor regression | PMC3158010 |
Athymic nude mice | ES-2-luc ovarian cancer xenograft model | Intraperitoneal injection | 2.0 mg/kg (Epothilone B), 15.0 mg/kg (17-AAG), 7.5 mg/kg (rapamycin) | Single injection | Evaluate the antitumor efficacy of Epothilone B combined with 17-AAG and rapamycin in an ES-2-luc ovarian cancer xenograft model, showing that a single intraperitoneal injection of g-EAR significantly delayed tumor growth with a median survival time of 58 days. | PMC5722673 |
Nude mice | RKO cell xenograft model | Intraperitoneal injection | 2.5 mg/kg and 5 mg/kg | Every two days for 20 days | To evaluate the antitumor activity of UTD1 in vivo, results showed UTD1 significantly inhibited tumor growth and was more effective and safer than paclitaxel and 5-FU | PMC8016927 |
Sprague-Dawley rats | Spinal cord injury model | Intraperitoneal injection | 2x0.75 mg/kg | Single injection | To evaluate the effect of Epothilone B on functional recovery after spinal cord injury. Results showed that Epothilone B reshaped the SCI microenvironment by increasing cytokine secretion, which inhibited functional recovery. | PMC5775408 |
Nude mice | SKOV-3 tumor model | Intravenous injection | 5 mg/kg and 10 mg/kg | Every 3 days for 24 days | Evaluate antitumor efficacy of Z-E ADCN in SKOV-3 tumor model | PMC11337599 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT00077259 | Colorectal Cancer | Phase 2 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Less << |
NCT00080301 | Breast Cancer ... More >> Metastases Less << | Phase 3 | Completed | - | - |
NCT00080301 | - | Completed | - | - | |
NCT00082433 | - | Completed | - | - | |
NCT00977574 | Endometrial Adenocarcinoma ... More >> Endometrial Adenosquamous Carcinoma Endometrial Clear Cell Adenocarcinoma Endometrial Serous Adenocarcinoma Recurrent Uterine Corpus Carcinoma Stage IIIA Uterine Corpus Cancer AJCC v7 Stage IIIB Uterine Corpus Cancer AJCC v7 Stage IIIC Uterine Corpus Cancer AJCC v7 Stage IVA Uterine Corpus Cancer AJCC v7 Stage IVB Uterine Corpus Cancer AJCC v7 Less << | Phase 2 | Active, not recruiting | - | - |
NCT00977574 | - | Active, not recruiting | - | - | |
NCT01375829 | Adult Solid Neoplasm | Phase 1 | Active, not recruiting | - | United States, Florida ... More >> Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Less << |
NCT00785291 | - | Active, not recruiting | - | - | |
NCT00082433 | Cancer Breast... More >> Cancer Less << | Phase 3 | Completed | - | - |
NCT01097642 | Breast Cancer | Phase 2 | Active, not recruiting | December 2019 | United States, Texas ... More >> The Methodist Hospital Cancer Center Houston, Texas, United States, 77030 Less << |
NCT00331344 | Adenocarcinoma of the Prostate... More >> Recurrent Prostate Cancer Stage IV Prostate Cancer Less << | Phase 1 Phase 2 | Completed | - | United States, California ... More >> UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94143-0875 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Less << |
NCT00877500 | Bilateral Breast Carcinoma ... More >> HER2/Neu Negative Invasive Breast Carcinoma Less << | Phase 2 | Active, not recruiting | April 30, 2020 | United States, Illinois ... More >> Advocate Christ Medical Center Oak Lawn, Illinois, United States, 60453-2699 United States, Texas Lyndon Baines Johnson General Hospital Houston, Texas, United States, 77026-1967 M D Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT00331344 | - | Completed | - | - | |
NCT00077376 | HER2-positive Breast Cancer ... More >> Male Breast Cancer Recurrent Breast Cancer Stage IV Breast Cancer Less << | Phase 2 | Completed | - | United States, Massachusetts ... More >> Eastern Cooperative Oncology Group Boston, Massachusetts, United States, 02215 Less << |
NCT00785291 | Estrogen Receptor Negative ... More >> Estrogen Receptor Positive HER2/Neu Negative HER2/Neu Positive Progesterone Receptor Negative Progesterone Receptor Positive Recurrent Breast Carcinoma Stage IIIC Breast Cancer AJCC v6 Stage IV Breast Cancer AJCC v6 and v7 Less << | Phase 3 | Active, not recruiting | - | - |
NCT00077376 | - | Completed | - | - | |
NCT01084057 | Male Breast Cancer ... More >> Recurrent Breast Cancer Stage IV Breast Cancer Less << | Phase 1 | Active, not recruiting | June 2019 | United States, California ... More >> City of Hope Duarte, California, United States, 91010 South Pasadena Cancer Center South Pasadena, California, United States, 91030 Less << |
NCT00058084 | Adenocarcinoma of the Prostate... More >> Recurrent Prostate Cancer Stage IV Prostate Cancer Less << | Phase 2 | Completed | - | United States, California ... More >> UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94143-0875 Less << |
NCT01168232 | Recurrent Uterine Corpus Sarco... More >>ma Uterine Carcinosarcoma Less << | Phase 2 | Completed | - | - |
NCT01168232 | - | Completed | - | - | |
NCT00182767 | Fallopian Tube Cancer ... More >> Female Reproductive Cancer Recurrent Breast Cancer Recurrent Ovarian Epithelial Cancer Stage III Ovarian Epithelial Cancer Stage IV Breast Cancer Stage IV Ovarian Epithelial Cancer Less << | Phase 1 Phase 2 | Completed | - | United States, Connecticut ... More >> University of Connecticut Farmington, Connecticut, United States, 06030 United States, New York Women's Cancer Care Associates LLC Albany, New York, United States, 12208 Albert Einstein College of Medicine Bronx, New York, United States, 10461 Montefiore Medical Center - Moses Campus Bronx, New York, United States, 10467-2490 Weill Medical College of Cornell University New York, New York, United States, 10065 Less << |
NCT00884676 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, Florida ... More >> University of Miami Sylvester Comprehensive Cancer Center Miami, Florida, United States, 33136 Less << |
NCT00182767 | - | Completed | - | - | |
NCT00079326 | - | Terminated(Slow accrual.) | - | - | |
NCT00079326 | HER2-positive Breast Cancer ... More >> Recurrent Breast Cancer Stage IV Breast Cancer Less << | Phase 2 | Terminated(Slow accrual.) | - | United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Less << |
NCT01454479 | Recurrent Endometrial Cancer | Phase 1 | Unknown | April 2014 | - |
NCT00033618 | Metastatic Squamous Neck Cance... More >>r With Occult Primary Squamous Cell Carcinoma Recurrent Metastatic Squamous Neck Cancer With Occult Primary Recurrent Salivary Gland Cancer Recurrent Squamous Cell Carcinoma of the Hypopharynx Recurrent Squamous Cell Carcinoma of the Larynx Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity Recurrent Squamous Cell Carcinoma of the Oropharynx Recurrent Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Recurrent Verrucous Carcinoma of the Larynx Recurrent Verrucous Carcinoma of the Oral Cavity Salivary Gland Squamous Cell Carcinoma Stage IV Squamous Cell Carcinoma of the Hypopharynx Stage IVA Salivary Gland Cancer Stage IVA Squamous Cell Carcinoma of the Larynx Stage IVA Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IVA Squamous Cell Carcinoma of the Oropharynx Stage IVA Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Stage IVA Verrucous Carcinoma of the Larynx Stage IVA Verrucous Carcinoma of the Oral Cavity Stage IVB Salivary Gland Cancer Stage IVB Squamous Cell Carcinoma of the Larynx Stage IVB Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IVB Squamous Cell Carcinoma of the Oropharynx Stage IVB Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Stage IVB Verrucous Carcinoma of the Larynx Stage IVB Verrucous Carcinoma of the Oral Cavity Stage IVC Salivary Gland Cancer Stage IVC Squamous Cell Carcinoma of the Larynx Stage IVC Squamous Cell Carcinoma of the Lip and Oral Cavity Stage IVC Squamous Cell Carcinoma of the Oropharynx Stage IVC Squamous Cell Carcinoma of the Paranasal Sinus and Nasal Cavity Stage IVC Verrucous Carcinoma of the Larynx Stage IVC Verrucous Carcinoma of the Oral Cavity Tongue Cancer Less << | Phase 2 | Completed | - | United States, Massachusetts ... More >> Eastern Cooperative Oncology Group Boston, Massachusetts, United States, 02215 Less << |
NCT00045708 | Adult Anaplastic Astrocytoma ... More >> Adult Giant Cell Glioblastoma Adult Gliosarcoma Recurrent Adult Brain Tumor Less << | Phase 1 Phase 2 | Completed | - | United States, Georgia ... More >> Emory University Atlanta, Georgia, United States, 30322 United States, Maryland Johns Hopkins University Baltimore, Maryland, United States, 21287 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, North Carolina Wake Forest University Winston-Salem, North Carolina, United States, 27157 United States, Ohio Cleveland Clinic Cleveland, Ohio, United States, 44106 Less << |
NCT00087139 | Adenocarcinoma of the Prostate... More >> Recurrent Prostate Cancer Stage IV Prostate Cancer Less << | Phase 2 | Completed | - | - |
NCT00087139 | - | Completed | - | - | |
NCT00095979 | Endometrial Adenocarcinoma ... More >> Recurrent Endometrial Carcinoma Stage IV Endometrial Carcinoma Less << | Phase 2 | Completed | - | United States, Pennsylvania ... More >> Gynecologic Oncology Group Philadelphia, Pennsylvania, United States, 19103 Less << |
NCT00095979 | - | Completed | - | - | |
NCT00025194 | Prostate Cancer | Phase 1 Phase 2 | Completed | - | United States, California ... More >> UCSF Comprehensive Cancer Center San Francisco, California, United States, 94115 United States, Massachusetts Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109-0942 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Less << |
NCT00057850 | Head and Neck Cancer | Phase 1 Phase 2 | Completed | - | United States, Pennsylvania ... More >> Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 Less << |
NCT00030108 | Brain and Central Nervous Syst... More >>em Tumors Childhood Germ Cell Tumor Extragonadal Germ Cell Tumor Kidney Cancer Leukemia Liver Cancer Neuroblastoma Ovarian Cancer Sarcoma Unspecified Childhood Solid Tumor, Protocol Specific Less << | Phase 1 | Completed | - | United States, District of Col... More >>umbia Children's National Medical Center Washington, District of Columbia, United States, 20010-2970 United States, Maryland Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office Bethesda, Maryland, United States, 20892-1182 Less << |
NCT00045708 | - | Completed | - | - | |
NCT00016393 | Prostate Cancer | Phase 2 | Completed | - | - |
NCT00030706 | Ovarian Cancer ... More >> Peritoneal Cavity Cancer Less << | Phase 2 | Completed | - | United States, New York ... More >> Albert Einstein Cancer Center at Albert Einstein College of Medicine Bronx, New York, United States, 10461 Less << |
NCT00045097 | Breast Cancer | Phase 2 | Completed | - | United States, Maryland ... More >> Suburban Hospital Bethesda, Maryland, United States, 20814 Oncology Care Associates Bethesda, Maryland, United States, 20817 Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support Bethesda, Maryland, United States, 20892-1182 NCI - Center for Cancer Research Bethesda, Maryland, United States, 20892 Less << |
NCT00016965 | Pancreatic Cancer | Phase 2 | Completed | - | - |
NCT00020904 | Breast Cancer | Phase 2 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Herbert Irving Comprehensive Cancer Center New York, New York, United States, 10032 Less << |
NCT00182702 | Clear Cell Renal Cell Carcinom... More >>a Recurrent Renal Cell Cancer Stage III Renal Cell Cancer Stage IV Renal Cell Cancer Less << | Phase 2 | Completed | - | United States, Illinois ... More >> University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637-1470 Less << |
NCT00005807 | Breast Cancer ... More >> Ovarian Cancer Unspecified Adult Solid Tumor, Protocol Specific Less << | Phase 1 | Completed | - | United States, New York ... More >> Albert Einstein Clinical Cancer Center Bronx, New York, United States, 10461 NYU School of Medicine's Kaplan Comprehensive Cancer Center New York, New York, United States, 10016 Less << |
NCT00022477 | Colorectal Cancer | Phase 2 | Completed | - | United States, Illinois ... More >> University of Illinois at Chicago Chicago, Illinois, United States, 60612 University of Chicago Cancer Research Center Chicago, Illinois, United States, 60637-1470 Louis A. Weiss Memorial Hospital Chicago, Illinois, United States, 60640 Decatur Memorial Hospital Cancer Care Institute Decatur, Illinois, United States, 62526 Evanston Northwestern Health Care Evanston, Illinois, United States, 60201 Ingalls Memorial Hospital Harvey, Illinois, United States, 60426 LaGrange Memorial Hospital LaGrange, Illinois, United States, 60525 Loyola University Medical Center Maywood, Illinois, United States, 60153 Lutheran General Cancer Care Center Park Ridge, Illinois, United States, 60068 Oncology/Hematology Associates of Central Illinois, P.C. Peoria, Illinois, United States, 61602 Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 62701 United States, Indiana Fort Wayne Medical Oncology and Hematology, Inc. Fort Wayne, Indiana, United States, 46885-5099 Michiana Hematology/Oncology P.C. South Bend, Indiana, United States, 46601 United States, Michigan Lakeland Medical Center - St. Joseph Saint Joseph, Michigan, United States, 49085 United States, New York Albert Einstein Comprehensive Cancer Center Bronx, New York, United States, 10461 Less << |
NCT00924066 | - | Completed | - | - | |
NCT00028561 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Terminated(Administratively co... More >>mplete.) Less << | - | United States, Florida ... More >> H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 Less << |
NCT00049400 | Lymphoma Smal... More >>l Intestine Cancer Unspecified Adult Solid Tumor, Protocol Specific Less << | Phase 1 | Completed | - | United States, California ... More >> City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010-3000 USC/Norris Comprehensive Cancer Center and Hospital Los Angeles, California, United States, 90089-9181 University of California Davis Cancer Center Sacramento, California, United States, 95817 United States, Illinois Cardinal Bernardin Cancer Center at Loyola University Medical Center Maywood, Illinois, United States, 60153 United States, Kansas Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center Kansas City, Kansas, United States, 66160-7357 United States, Ohio Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106 Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 Community Oncology Group at Cleveland Clinic Cancer Center Independence, Ohio, United States, 44131 Cleveland Clinic - Wooster Wooster, Ohio, United States, 44691 United States, Texas Brooke Army Medical Center Fort Sam Houston, Texas, United States, 78234 Wilford Hall Medical Center Lackland AFB, Texas, United States, 78236 University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78229-3900 United States, Washington St. Joseph Hospital Community Cancer Center Bellingham, Washington, United States, 98225 Olympic Hematology and Oncology Bremerton, Washington, United States, 98310 Skagit Valley Hospital Cancer Care Center Mt. Vernon, Washington, United States, 98273 Group Health Central Hospital Seattle, Washington, United States, 98104-1387 Fred Hutchinson Cancer Research Center Seattle, Washington, United States, 98104 Harborview Medical Center Seattle, Washington, United States, 98104 Swedish Cancer Institute at Swedish Medical Center - First Hill Campus Seattle, Washington, United States, 98122-4307 University Cancer Center at University of Washington Medical Center Seattle, Washington, United States, 98195-6043 North Puget Oncology at United General Hospital Sedro-Wooley, Washington, United States, 98284 Cancer Care Northwest - Spokane South Spokane, Washington, United States, 99202 Wenatchee Valley Medical Center Wenatchee, Washington, United States, 98801-2028 Less << |
NCT00030992 | Renal Cell Carcinoma | Phase 2 | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT00036764 | Recurrent Melanoma ... More >> Stage IV Melanoma Less << | Phase 2 | Completed | - | United States, New York ... More >> New York University Clinical Cancer Center New York, New York, United States, 10016-4760 Less << |
NCT00052572 | Leukemia Lymp... More >>homa Less << | Phase 2 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 United States, Vermont Vermont Cancer Center at University of Vermont Burlington, Vermont, United States, 05401-3498 Less << |
NCT00025155 | Primary Peritoneal Cavity Canc... More >>er Recurrent Ovarian Epithelial Cancer Less << | Phase 2 | Completed | - | United States, Pennsylvania ... More >> Gynecologic Oncology Group Philadelphia, Pennsylvania, United States, 19103 Less << |
NCT00025155 | - | Completed | - | - | |
NCT00058019 | Anaplastic Large Cell Lymphoma... More >> Recurrent Adult Burkitt Lymphoma Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Less << | Phase 2 | Completed | - | United States, Illinois ... More >> University of Chicago Chicago, Illinois, United States, 60637 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT00030992 | - | Completed | - | - | |
NCT00331643 | Adult Rhabdomyosarcoma ... More >> Adult Synovial Sarcoma Alveolar Childhood Rhabdomyosarcoma Childhood Synovial Sarcoma Embryonal Childhood Rhabdomyosarcoma Previously Treated Childhood Rhabdomyosarcoma Recurrent Adult Soft Tissue Sarcoma Recurrent Childhood Rhabdomyosarcoma Recurrent Childhood Soft Tissue Sarcoma Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Recurrent Neuroblastoma Recurrent Osteosarcoma Recurrent Wilms Tumor and Other Childhood Kidney Tumors Less << | Phase 2 | Completed | - | United States, California ... More >> Children's Oncology Group Arcadia, California, United States, 91006-3776 Less << |
NCT00058019 | - | Completed | - | - | |
NCT00924066 | Cervical Carcinoma ... More >> Cervical Adenocarcinoma Cervical Adenosquamous Carcinoma Cervical Carcinoma, Non-SquamousType Less << | Phase 2 | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT00022542 | Recurrent Adult Soft Tissue Sa... More >>rcoma Stage III Adult Soft Tissue Sarcoma Stage IV Adult Soft Tissue Sarcoma Less << | Phase 2 | Terminated | - | United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less << |
NCT00023946 | Adult Primary Cholangiocellula... More >>r Carcinoma Adult Primary Hepatocellular Carcinoma Advanced Adult Primary Liver Cancer Cholangiocarcinoma of the Extrahepatic Bile Duct Cholangiocarcinoma of the Gallbladder Localized Extrahepatic Bile Duct Cancer Localized Gallbladder Cancer Localized Resectable Adult Primary Liver Cancer Localized Unresectable Adult Primary Liver Cancer Recurrent Adult Primary Liver Cancer Recurrent Extrahepatic Bile Duct Cancer Recurrent Gallbladder Cancer Unresectable Extrahepatic Bile Duct Cancer Unresectable Gallbladder Cancer Less << | Phase 2 | Terminated | - | United States, Illinois ... More >> University of Chicago Chicago, Illinois, United States, 60637 Less << |
NCT00407251 | Hormone Refractory Prostate Ca... More >>ncer Less << | PHASE2 | COMPLETED | - | Tom Baker Cancer Centre, Calga... More >>ry, Alberta, T4N 4N2, Canada|BC Cancer Agency - Vancouver Centre, Vancouver, British Columbia, V5Z 4E6, Canada|Juravinski Cancer Centre, Hamilton, Ontario, L8B 5C2, Canada|London Health Sciences Centre, London, Ontario, N6A 4L6, Canada|Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada Less << |
NCT00411528 | Metastatic Hormone Refractory ... More >>Prostate Cancer Less << | Phase 2 | Completed | - | - |
NCT00021099 | Distal Urethral Cancer ... More >> Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter Proximal Urethral Cancer Recurrent Bladder Cancer Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter Recurrent Urethral Cancer Regional Transitional Cell Cancer of the Renal Pelvis and Ureter Stage III Bladder Cancer Stage IV Bladder Cancer Transitional Cell Carcinoma of the Bladder Urethral Cancer Associated With Invasive Bladder Cancer Less << | Phase 2 | Completed | - | United States, Massachusetts ... More >> Eastern Cooperative Oncology Group Boston, Massachusetts, United States, 02215 Less << |
NCT00421044 | Advanced Malignancies ... More >> Tumors Less << | Phase 1 | Completed | - | United States, California ... More >> University of California San Diego/Moores Cancer Center La Jolla, California, United States, 92093-0987 United States, Texas Institute for Drug Development Cancer Therapy & Research Center/The University of Texas Health Science Center San Antonio, Texas, United States, 78229 South Texas Accelerated Research Therapeutics San Antonio, Texas, United States, 78229 Less << |
NCT00035087 | Colorectal Neoplasms ... More >> Colonic Neoplasms Less << | Phase 2 | Completed | - | United States, New Jersey ... More >> Cancer Institute of New Jersey (CINJ) New Brunswick, New Jersey, United States, 08901 Less << |
NCT00035113 | Prostatic Neoplasms | Phase 2 | Completed | - | United States, California ... More >> Pacific Shores Medical Group Long Beach, California, United States, 90813 California Pacific Medical Center San Francisco, California, United States, 94115 United States, Maryland University of Maryland - Greenbaum Cancer Center Baltimore, Maryland, United States, 21201 United States, New Jersey Cancer Institute of New Jersey (CINJ) New Brunswick, New Jersey, United States, 08901 United States, Washington Seattle Cancer Care Alliance Seattle, Washington, United States, 98109 Less << |
NCT00468260 | Advanced Malignancies | PHASE1 | TERMINATED | - | San Antonio, Texas, United Sta... More >>tes Less << |
NCT00715013 | Recurrent Glioblastoma Planned... More >> for Reoperation Less << | PHASE1|PHASE2 | COMPLETED | 2025-12-10 | - |
NCT00035126 | Breast Neoplasms | Phase 2 | Completed | - | United States, New Hampshire ... More >> Dartmouth Hitchcock Medical Center Lebanon, New Hampshire, United States, 03756 United States, New Jersey Cancer Institute of New Jersey (CINJ) New Brunswick, New Jersey, United States, 08901 Less << |
NCT00420524 | Advanced Malignancies ... More >> Tumors Less << | Phase 1 | Completed | - | United States, California ... More >> University of California San Diego/Moores Cancer Center La Jolla, California, United States, 92093-0987 United States, New Mexico Cancer Research and Treatment Center Albuquerque, New Mexico, United States, 87131-5636 United States, Texas Institute for Drug Development Cancer Therapy & Research Center/The University of Texas Health Science San Antonio, Texas, United States, 78229 South Texas Accelerated Research Therapeutics San Antonio, Texas, United States, 78229 Less << |
NCT00496600 | Refractory Malignancy | Phase 1 | Completed | - | United States, New Jersey ... More >> The Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08901 Less << |
NCT00035243 | Kidney Neoplasms | Phase 2 | Completed | - | United States, California ... More >> UCLA Medical Center Los Angeles, California, United States, 90095 United States, Maryland University of Maryland Baltimore, Maryland, United States, 21201 United States, Michigan Wayne State University Karmanos Cancer Center Detroit, Michigan, United States, 48201 United States, New York Our Lady Of Mercy Medical Center Bronx, New York, United States, 10466 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 United States, Washington University of Washington Seattle, Washington, United States, 98109 France Centre L. Berard Lyon, France Institut Gustave Roussy Villejuif, France Less << |
NCT00426140 | Advanced Malignancies|Solid Tu... More >>mors Less << | PHASE1 | COMPLETED | - | Cancer Therapy and Research Ce... More >>nter, Institution for Drug Development, San Antonio, Texas, 78229, United States Less << |
NCT00442741 | Solid Tumors | Phase 1 | Withdrawn(pts. will be capture... More >>d in core) Less << | - | - |
NCT00159484 | Colon Cancer ... More >>Colorectal Cancer Less << | Phase 1 Phase 2 | Active, not recruiting | December 2017 | United States, California ... More >> U.S.C./Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 Less << |
NCT00262990 | Ovarian Cancer ... More >> Fallopian Tube Cancer Peritoneal Neoplasms Less << | Phase 3 | Completed | - | - |
NCT00448396 | Advanced Malignancies | PHASE1 | COMPLETED | - | San Antonio, Texas, United Sta... More >>tes Less << |
NCT00426582 | Advanced Solid Tumors | PHASE1 | COMPLETED | - | Norwalk Hospital, Norwalk, Con... More >>necticut, 06856, United States|Associates in Oncology, Rockville, Maryland, 20850, United States|Wertz Clinical Cancer Center (Wayne State University), Detroit, Michigan, 48201, United States|Siteman Cancer Center (Washington University School of Medicine), Saint Louis, Missouri, 63110-1093, United States|Cancer Research and Treatment Center (University of New Mexico), Albuquerque, New Mexico, 87131, United States Less << |
NCT00328458 | Central Nervous System Neoplas... More >>ms Head and Neck Neoplasms Less << | Phase 1 | Completed | - | United States, Pennsylvania ... More >> Thomas Jefferson University Hospital Philadelphia, Pennsylvania, United States, 19107 Less << |
NCT00035165 | Melanoma | Phase 2 | Completed | - | United States, Colorado ... More >> University of Colorado Aurora, Colorado, United States, 80045 United States, Florida H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 United States, New York Comprehensive Cancer Center@ Our Lady if Mercy Medical Center Bronx, New York, United States, 10466-2697 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 United States, Oklahoma Oklahoma Oncology, Inc. Tulsa, Oklahoma, United States, 74104 United States, Pennsylvania UPMC Health Systems Pittsburgh, Pennsylvania, United States, 15213 Less << |
NCT00035100 | Ovarian Neoplasms ... More >> Peritoneal Neoplasms Fallopian Tube Neoplasms Less << | Phase 2 | Completed | - | United States, New Jersey ... More >> Novartis Investigative Site New Brunswick, New Jersey, United States, 08901 Canada, Ontario Novartis Investigative Site Toronto, Ontario, Canada, M5G 2M9 Netherlands Novartis Investigative Site Amsterdam, Netherlands, 1066 CX Novartis Investigative Site Enschede, Netherlands, 7513 ER Novartis Investigative Site Zwolle, Netherlands, 8025 AB Slovakia Novartis Investigative Site Bratislava, Slovakia, 812 50 Novartis Investigative Site Kosice, Slovakia, 04190 United Kingdom Novartis Investigative Site Surrey, United Kingdom, SM2 5PT Less << |
NCT00273312 | Hepatocellular Carcinoma | PHASE2 | COMPLETED | - | Novartis Investigative Site, S... More >>an Francisco, California, 94115, United States|Novartis Investigative Site, Hong Kong, Shatin, NT, Hong Kong|Novartis Investigative Site, Hong Kong, Hong Kong|Novartis Investigative Site, Seoul, Korea, 110 744, Korea, Republic of|Novartis Investigative Site, Seoul, 738-736, Korea, Republic of|Novartis Investigative Site, Taipei, Taiwan ROC, 100, Taiwan|Novartis Investigative Site, Tai Chung Municipality, Taiwan Less << |
NCT00219297 | Brain Metastasis|Non-small Cel... More >>l Lung Cancer Less << | PHASE2 | COMPLETED | 2010-06-24 | University of California Davis... More >> Cancer Center UC Davis Cancer (3), Sacramento, California, 95817, United States|Dana Farber Cancer Institute SC, Boston, Massachusetts, 02115, United States|Wayne State University/Wertz Clinical Cancer Center Div. of Hematology/Oncology, Detroit, Michigan, 48201, United States|St Louis University Cancer Center, Saint Louis, Missouri, 63110, United States|Washington University School of Medicine-Siteman Cancer Ctr, Saint Louis, Missouri, 63110, United States|Dartmouth Hitchcock Medical Center Oncology, Lebanon, New Hampshire, 03756, United States|Roswell Park Cancer Institute, Buffalo, New York, 14263, United States|Memorial Sloan Kettering Cancer Center, New York, New York, 10022, United States|Columbia University Medical Center New York Presbyterian, New York, New York, 10032, United States|Duke University Medical Center Dept. of DUMC (3), Durham, North Carolina, 27710, United States|Cleveland Clinic Foundation, Cleveland, Ohio, 44195, United States|University of Wisconsin Hospital and Clinics, Madison, Wisconsin, 53792, United States Less << |
NCT00420615 | Solid Tumors | Phase 1 | Completed | - | United States, Texas ... More >> The University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Less << |
NCT00171834 | Carcinoma, Non-Small-Cell Lung | PHASE1|PHASE2 | COMPLETED | 2025-09-08 | Norton Healthcare/Hospital Inc... More >>, Louisville, Kentucky, 40232-5070, United States|Ellis Fisher Cancer Center, Columbia, Missouri, 65203, United States|Hillman Cancer Center, Pittsburg, Pennsylvania, 15232, United States|MD Anderson Cancer Center, Houston, Texas, 77030-4009, United States Less << |
NCT00050349 | Carcinoid Neu... More >>roendocrine Tumors Less << | Phase 2 | Completed | - | United States, Illinois ... More >> Northwestern University Chicago, Illinois, United States, 60611 United States, Iowa University of Iowa Health Care Iowa City, Iowa, United States, 52242-1091 United States, Louisiana LSU HEALTH SCIENCES CENTER/ LSU SCHOOL OF MEDICINE Deptof LSU Health Sciences (2) New Orleans, Louisiana, United States, 70115 United States, New York Weill Medical College of Cornell Univ. New York, New York, United States, 10021 United States, Oregon Oregon Health Sciences University Portland, Oregon, United States, 97201 Less << |
NCT00171834 | Carcinoma, Non-Small-Cell Lung | PHASE1|PHASE2 | COMPLETED | 2025-09-08 | Norton Healthcare/Hospital Inc... More >>, Louisville, Kentucky, 40232-5070, United States|Ellis Fisher Cancer Center, Columbia, Missouri, 65203, United States|Hillman Cancer Center, Pittsburg, Pennsylvania, 15232, United States|MD Anderson Cancer Center, Houston, Texas, 77030-4009, United States Less << |
NCT00969046 | Colon Cancer | Phase 1 | Completed | - | Czech Republic ... More >> Novartis Investigative Site Hradec Králové, Czech Republic Novartis Investigative Site Prague, Czech Republic France Novartis Investigative Site Saint-Herblain Cedex, France Novartis Investigative Site Toulouse, France Spain Novartis Investigative Site Barcelona, Spain United Kingdom Novartis Investigative Site London, United Kingdom Less << |
NCT00450866 | - | Completed | - | - | |
NCT00450866 | Breast Cancer ... More >> Metastatic Cancer Less << | Phase 2 | Completed | - | United States, Massachusetts ... More >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Ohio Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106-5065 Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44195 Less << |
NCT00412789 | Tumors | PHASE1 | COMPLETED | - | Novartis Investigative Site, T... More >>okyo, Japan Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
1.97mL 0.39mL 0.20mL |
9.85mL 1.97mL 0.98mL |
19.70mL 3.94mL 1.97mL |