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Chemical Structure| 1808986-37-9 Chemical Structure| 1808986-37-9

Structure of ERCC1-XPF-IN-2
CAS No.: 1808986-37-9

Chemical Structure| 1808986-37-9

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ERCC1-XPF-IN-2 is a potent ERCC1-XPF nuclease inhibitor with an IC50 of 0.6 μM. This compound demonstrates activity in nucleotide excision repair, enhancing cisplatin efficacy, and γH2AX detection, suitable for cancer and DNA damage repair research.

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Product Details of ERCC1-XPF-IN-2

CAS No. :1808986-37-9
Formula : C15H13Cl2NO3
M.W : 326.17
SMILES Code : O=C(NCC1=CC=C(O)C(O)=C1)CC2=CC=C(Cl)C=C2Cl
MDL No. :MFCD34676435

Safety of ERCC1-XPF-IN-2

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of ERCC1-XPF-IN-2

DNA

Isoform Comparison

Biological Activity

Description
ERCC1-XPF-IN-2 is an effective ERCC1-XPF endonuclease inhibitor, exhibiting an IC50 of 0.6 µM. It is active in nucleotide excision repair, enhances cisplatin efficacy, and is involved in γH2AX assays[1].

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1 mM

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3.07mL

0.61mL

0.31mL

15.33mL

3.07mL

1.53mL

30.66mL

6.13mL

3.07mL

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