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Chemical Structure| 84611-23-4 Chemical Structure| 84611-23-4

Structure of Erdosteine
CAS No.: 84611-23-4

Chemical Structure| 84611-23-4

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Erdosteine is a thiol derivative used as a mucolytic.

Synonyms: RV 144; Erdostin; PV 144

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Product Details of Erdosteine

CAS No. :84611-23-4
Formula : C8H11NO4S2
M.W : 249.31
SMILES Code : O=C(O)CSCC(NC(CCS1)C1=O)=O
Synonyms :
RV 144; Erdostin; PV 144
MDL No. :MFCD00867664
InChI Key :QGFORSXNKQLDNO-UHFFFAOYSA-N
Pubchem ID :65632

Safety of Erdosteine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Related Pathways of Erdosteine

pyroptosis

Isoform Comparison

Biological Activity

Description
Erdosteine effectively inhibits lipopolysaccharide (LPS)-induced NF-κB activation, demonstrating its anti-inflammatory capabilities[1].[2].

In Vitro:

Cell Line
Concentration Treated Time Description References
Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 2 mg/L 24 h To evaluate the effect of Erdosteine and its metabolite on MRSA biofilm formation. Results showed that 2 mg/L Erdosteine increased the number of biofilm-dwelling cells in ATCC 43300 strain by 73.0%. PMC8698571

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Wistar albino female rats Letrozole-induced polycystic ovary syndrome (PCOS) rat model Oral 100 mg/kg Once daily for 30 days To investigate the therapeutic effects of Erdosteine on PCOS. Results showed that Erdosteine reduced ovarian weight, numbers of atretic and cystic follicles, increased corpus luteum count, and improved lipid parameters, hormone levels, and insulin resistance. PMC6422144

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03368053 Infection, Human Immunodeficie... More >>ncy Virus Less << Phase 1 Completed - Belgium ... More >> GSK Investigational Site Gent, Belgium, 9000 Less <<
NCT02109354 HIV Infection Phase 1 Unknown April 2016 South Africa ... More >> Emavundleni Desmond Tutu HIV Centre CRS Cape Town, Western Cape, South Africa, 7750 Aurum Institute for Health Research Klerksdorp, South Africa, 2570 Perinatal HIV Research Unit Soweto, South Africa, 2013 Less <<
NCT00223080 - Completed - -
NCT00223080 HIV Infection Phase 3 Completed - Thailand ... More >> Ban Lamung District Hospital Ban Lamung District, Chon Buri, Thailand Phan Tong District Hospital Phan Tong District, Chon Buri, Thailand, 20160 Sattahip District Hospital Sattahip District, Chon Buri, Thailand, 20180 Ao Udom Hospital Sri Racha District, Chon Buri, Thailand, 20230 Ban Chang District Hospital Ban Chang District, Rayong, Thailand Ban Khai District Hospital Ban Khai District, Rayong, Thailand Klaeng District Hospital Klaeng District, Rayong, Thailand Provincial Health Office Muang District, Rayong, Thailand, 21000 Less <<
NCT00337181 - Completed - Thailand ... More >> Chon Buri Regional Hospital Chon Buri, Chon Buri Province, Thailand, 20000 Less <<
NCT01931358 HIV Infections Phase 2 Active, not recruiting October 2018 Thailand ... More >> Royal Thai Army Clinical Research Center, AFRIMS Bangkok, Thailand, 10400 Vaccine Trial Centre, Faculty of Tropical Medicine, Mahidol University Bangkok, Thailand, 10400 Research Institute for Health Sciences (RIHES), Chiang Mai University Chiang Mai, Thailand, 50202 Less <<
NCT01032304 Chronic Obstructive Pulmonary ... More >>Disease (COPD) Less << Phase 3 Unknown September 2015 -
NCT02332044 Healthy Phase 1 Completed - -
NCT01435135 HIV Infections Phase 2 Active, not recruiting December 2019 Thailand ... More >> Bang Lamung District Hospital Chon Buri, Thailand Phan Thong District Hospital Chon Buri, Thailand Less <<
NCT00338507 Chronic Bronchitis|Chronic Obs... More >>tructive Pulmonary Disease Less << PHASE2 COMPLETED - Omnicare Clinical Research, Ki... More >>ng of Prussia, Pennsylvania, 19406, United States Less <<
NCT01176318 Chronic Obstructive Pulmonary ... More >>Disease Less << Phase 4 Withdrawn(pharmaceutical grant... More >> was withdrawn, thus no financial support to conduct the study.) Less << - United Kingdom ... More >> Castle Hill Hospital Cottingham, East Yorkshire, United Kingdom, HU16 5JQ Less <<
NCT00337181 - Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.01mL

0.80mL

0.40mL

20.06mL

4.01mL

2.01mL

40.11mL

8.02mL

4.01mL

References

 

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