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Chemical Structure| 183321-74-6 Chemical Structure| 183321-74-6

Structure of Erlotinib
CAS No.: 183321-74-6

Chemical Structure| 183321-74-6

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Erlotinib is an EGFR tyrosine kinase inhibitor with an IC50 value of 2 nM for EGFR. Erlotinib has antitumor effects and can be used in research on non-small cell lung cancer and pancreatic cancer.

Synonyms: CP-358774; NSC 718781; OSI-774

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Product Details of Erlotinib

CAS No. :183321-74-6
Formula : C22H23N3O4
M.W : 393.44
SMILES Code : COCCOC1=CC2=NC=NC(NC3=CC=CC(C#C)=C3)=C2C=C1OCCOC
Synonyms :
CP-358774; NSC 718781; OSI-774
MDL No. :MFCD08063588

Safety of Erlotinib

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of Erlotinib

RTK
JAK-STAT

Isoform Comparison

Biological Activity

Target
  • EGFR/ErbB1

    HER1/EGFR, IC50:2 nM

  • EGFR/ErbB1

    EGFR, IC50:2 nM

In Vitro:

Cell Line
Concentration Treated Time Description References
Human proximal tubular epithelial cells (HKC-8) 2 µM 1 h To study the protective effect of Erlotinib on HKC-8 cells in the hypoxia/reoxygenation (H/R) model, results showed that Erlotinib inhibited EGFR activation and restored the expression of cleaved caspase-3 and PARP-1. Cell Death Dis. 2021 Jan 12;12(1):70.
SW1990 cells 10 μM 48 h To investigate the effect of erlotinib on apoptosis in SW1990 cells, results showed that erlotinib induced apoptosis. J Exp Clin Cancer Res. 2016 Sep 5;35(1):133.
MiaPaCa-2 cells 40 μM 48 h To investigate the effect of erlotinib on apoptosis in MiaPaCa-2 cells, results showed that erlotinib induced apoptosis. J Exp Clin Cancer Res. 2016 Sep 5;35(1):133.
HCC827 cells 1 μM 6 h To investigate the transcriptional response to EGFR inhibition, SOX2 was found to be rapidly and specifically induced following EGFR inhibition. Elife. 2015 Feb 16;4:e06132.
PC9 cells 0.1 μM 24 h To study the effect of erlotinib on EGFR-mutant lung cancer cells, SOX2 was induced following EGFR inhibition and was associated with apoptosis. Elife. 2015 Feb 16;4:e06132.
gastric organoids 0.5 µM 6 days Erlotinib markedly decreased the expression of pit cell markers and increased the other cell markers, including Mki67, Sox9, and Pgc, confirming the specificity of EGFR signaling-dependent pit cell differentiation. Nat Commun. 2023 Jun 29;14(1):3750.
A549 10 μM 4 h To evaluate the effect of Erlotinib on GDH activity and intracellular α-KG levels. Results showed that Erlotinib significantly reduced GDH activity and α-KG levels. Cell Rep. 2022 Dec 13;41(11):111827.
HCC827 1 nM 24 h To evaluate the effect of Erlotinib on the invasive potential of HCC827 cells. Results showed that Erlotinib significantly inhibited cell invasion. Cell Rep. 2022 Dec 13;41(11):111827.
PC9 1 nM 24 h To evaluate the effect of Erlotinib on the invasive potential of PC9 cells. Results showed that Erlotinib significantly inhibited cell invasion. Cell Rep. 2022 Dec 13;41(11):111827.
primary human hepatocytes 5 μM 24-48 h To evaluate the effect of ritonavir and efavirenz on the metabolism of erlotinib. Results showed that ritonavir significantly inhibited the metabolism of erlotinib, increasing its half-life, while efavirenz decreased the half-life of erlotinib. Drug Metab Dispos. 2013 Oct;41(10):1843-51

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Nude mice Glioblastoma patient-derived xenograft model Not specified 33 mg/kg and 100 mg/kg Single dose, euthanized 2 hours post-dose To investigate the distribution of erlotinib in a glioblastoma model and its inhibitory effect on EGFR signaling, results showed that erlotinib delivery to intracranial tumors is insufficient to inhibit EGFR tyrosine kinase signaling. Nat Commun. 2018 Nov 21;9(1):4904
Mice Acute kidney injury (AKI) model Oral gavage 80 mg/kg Daily, until post-surgery To study the effect of Erlotinib on MMP-10-mediated renal protection, results showed that Erlotinib inhibited EGFR signaling and abolished the protective effects of MMP-10 on renal function. Cell Death Dis. 2021 Jan 12;12(1):70.
Mice Radiation injury model Oral 10 μg/g Once daily for 14 days Erlotinib significantly decreased both HSC regeneration and mice survival Nat Med. 2013 Mar;19(3):295-304
Mice LG1423 patient-derived xenograft model Oral 50 mg/kg Once daily for 21 days To evaluate the anti-tumor activity of Erlotinib in NSCLC harboring EGFR Ex20Ins mutations, results showed that Erlotinib induced less tumor growth inhibition compared to Osimertinib. Mol Cancer Ther. 2018 May;17(5):885-896.
Nude mice PC9 cell-derived subcutaneous tumor model Oral 100 mg/kg Single dose, tumors harvested 24 hours after treatment To investigate the effect of erlotinib on EGFR-mutant tumors, SOX2 was significantly increased following erlotinib treatment. Elife. 2015 Feb 16;4:e06132.
Mice Wild-type mice Oral 100 mg/kg Daily for 2 weeks Erlotinib markedly decreased the thickness of GKN2- and AQP3-expressing pit cell region, leading to the luminal shift of parietal cells. Conversely, the number of MKI67+ cells significantly increased in the mice treated with erlotinib, further supporting our in silico and gastric organoid data that EGFR signaling induces pit cell differentiation. Nat Commun. 2023 Jun 29;14(1):3750.

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01608841 Metastatic Pancreatic Cancer PHASE2 UNKNOWN 2025-10-15 Division of Gastroenterology, ... More >>Taipei Veterans General Hospital, Taipei, 11217, Taiwan Less <<
NCT01310036 Non-Squamous Non-Small Cell Lu... More >>ng Cancer Less << PHASE2 COMPLETED 2016-12-30 Princess Margaret Hospital; On... More >>cology, Hong Kong, Hong Kong|Queen Elizabeth Hospital; Clinical Oncology, Hong Kong, Hong Kong|Prince of Wales Hosp; Dept. Of Clinical Onc, Shatin, Hong Kong|Seoul National University Bundang Hospital, Gyeonggi-do, 13620, Korea, Republic of|Gil Hospital. Gachon University, Incheon, 405-760, Korea, Republic of|Asan Medical Center; Medical Oncology, Seoul, 05505, Korea, Republic of|Samsung Medical Center, Seoul, 06351, Korea, Republic of|Seoul St Mary's Hospital, Seoul, 06591, Korea, Republic of|Yonsei University Severance Hospital; Medical Oncology, Seoul, 120-752, Korea, Republic of|Changhua Christian Hospital; Internal Medicine, Changhua, 500, Taiwan|Kaohsiung Chang Gung Memorial Hospital; Dept of Internal Medicine, Kaohsiung, 00833, Taiwan|Veterans General Hospital; Internal Medicine, Kaohsiung, 813, Taiwan|China Medical University Hospital; Pulmonary and Critical Care Medicine, Taichung, 40447, Taiwan|Taichung Veterans General Hospital; Dept of Internal Medicine, Taichung, 407, Taiwan|National Cheng Kung Uni Hospital; Dept of Hematology and Oncology, Tainan, 704, Taiwan|Chi-Mei Medical Centre; Hematology & Oncology, Tainan, 710, Taiwan|National Taiwan Uni Hospital; Internal Medicine, Taipei, 100, Taiwan|Taipei Veterans General Hospital; Chest Dept , Section of Thoracic Oncology, Taipei, 112, Taiwan|Chang Gung Medical Foundation - Linkou; Chest Dept, Taoyuan, 333, Taiwan|Chulalongkorn Hospital; Medical Oncology, Bangkok, 10330, Thailand|Pramongkutklao Hospital; Medicine - Medical Oncology Unit, Bangkok, 10400, Thailand|Songklanagarind Hospital; Department of Internal Medicine, Division of Respiratory, Songkhla, 90110, Thailand Less <<
NCT00615758 Non Small Cell Lung Cancer PHASE2 COMPLETED 2025-11-09 401 Military Hospital, Medical... More >> Oncology Unit, Athens, Greece|Air Forces Military Hospital, Dep of Medical Oncology, Athens, Greece|IASO" General Hospital of Athens, 1st Dep of Medical Oncology, Athens, Greece|Sotiria" General Hospital, 2nd Dep of Pulmonary Diseases, Athens, Greece|"Diabalkaniko" Anticancer Hospital of Thessaloniki, Thessaloniki, Greece Less <<
NCT01664533 Non-Squamous Non-Small Cell Lu... More >>ng Cancer Less << COMPLETED 2025-08-13 Aalst, 9300, Belgium|Antwerpen... More >>, 2020, Belgium|Boussu, 7360, Belgium|Bruxelles, 1200, Belgium|Charleroi, 6000, Belgium|Dendermonde, 9200, Belgium|Duffel, 2570, Belgium|Edegem, 2650, Belgium|Frameries, 7080, Belgium|Genk, 3600, Belgium|Gilly, 6060, Belgium|Gosselies, 6041, Belgium|Liege, 4000, Belgium|Mons, 7000, Belgium|Montegnée, 4420, Belgium|Namur, 5000, Belgium|Ottignies, 1340, Belgium|Roeselare, 8800, Belgium|Sint Niklaas, 9100, Belgium|Tournai, 7500, Belgium|Turnhout, 2300, Belgium Less <<
NCT01174043 Leukemia, Myelomonocytic, Acut... More >>e Less << PHASE2 COMPLETED 2025-03-12 Indiana University Melvin and ... More >>Bren Simon Cancer Center, Indianapolis, Indiana, 46202, United States Less <<
NCT00448240 Head and Neck Cancer|Carcinoma... More >>, Squamous Cell Less << PHASE2|PHASE3 TERMINATED 2025-01-15 -
NCT02770014 Epidermal Growth Factor Recept... More >>or|Non-Small Cell Lung Cancer Less << PHASE2 TERMINATED 2019-06-19 Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02115, United States|Dana Farber Cancer Institute, Boston, Massachusetts, 02115, United States Less <<
NCT02595450 Non-Small Cell Lung Cancer COMPLETED 2025-11-14 Bludesch, 6712, Austria
NCT00301418 Glioblastoma Multiforme|Anapla... More >>stic Astrocytoma Less << PHASE1|PHASE2 COMPLETED 2025-05-14 Lenox Hill Brain Tumor Center,... More >> New York, New York, 10075, United States Less <<
NCT00750555 Head and Neck Cancer PHASE2 TERMINATED 2025-12-09 Geisinger Health System, Danvi... More >>lle, Pennsylvania, 17822, United States Less <<
NCT00391248 Non-small Cell Lung Cancer PHASE2 COMPLETED 2025-12-12 Juravinski Cancer Centre, Hami... More >>lton, Ontario, L8V 1C3, Canada|Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario, M5N 3M5, Canada Less <<
NCT01667562 Non-Small Cell Lung Cancer PHASE3 COMPLETED 2017-09-07 Clinic for Pulmonology, Clinic... More >>al Center of Serbia, Belgrade, 11000, Serbia|Clinical Center Bezanijska Kosa; Oncology, Belgrade, 11080, Serbia|Clinical Center Nis; Clinic for pulmonary diseases Knez Selo, Nis, Serbia|Institute for pulmonary diseases of Vojvodina, Sremska Kamenica, 21204, Serbia Less <<
NCT01130753 Lung Neoplasms|Erlotinib|Neoad... More >>juvant Therapy Less << PHASE2 COMPLETED 2025-12-12 Samsung Medical Center, Seoul,... More >> Korea, Republic of Less <<
NCT00410059 Lung Cancer PHASE2 COMPLETED 2025-07-16 University of Texas MD Anderso... More >>n Cancer Center, Houston, Texas, 77030, United States Less <<
NCT01470716 NSCLC Stage II|NSCLC, Stage II... More >>IA Less << PHASE2 UNKNOWN 2022-06-30 National Cancer Center, Goyang... More >>-si, Gyeonggi-do, 410-769, Korea, Republic of Less <<
NCT02066038 Lung, Carcinoma PHASE2 UNKNOWN 2025-03-16 -
NCT00570375 Myelodysplastic Syndrome PHASE2 WITHDRAWN 2025-04-09 University of Cincinnati, Cinc... More >>innati, Ohio, 45267, United States Less <<
NCT01260181 Non-Squamous Non-Small Cell Lu... More >>ng Cancer Less << PHASE2 COMPLETED 2017-09-29 Hospital Infante D. Pedro; Ser... More >>vico de Oncologia Medica, Aveiro, 3814-501, Portugal|Hospital Geral; Servico de Pneumologia, Coimbra, 3041-801, Portugal|IPO de Lisboa; Servico de Pneumologia, Lisboa, 1099-023, Portugal|Hospital Santo Antonio dos Capuchos;Servico de Oncologia Medica, Lisboa, 1150-314, Portugal|Hospital de Santa Maria; Servico de Pneumologia, Lisboa, 1600, Portugal|Hospital Pulido Valente; Servico de Pneumologia, Lisboa, 1796-001, Portugal|IPO do Porto; Servico de Oncologia Medica, Porto, 4200-072, Portugal|Hospital de Sao Joao; Servico de Pneumologia, Porto, 4200, Portugal|CHVNG/E_Unidade 1; Servico de Pneumologia, Vila Nova De Gaia, 4434-502, Portugal Less <<
NCT00597597 Metastatic Breast Cancer PHASE2 TERMINATED 2025-04-11 Rush University Medical Center... More >> Division of Hematology/Oncology, Chicago, Illinois, 60612, United States Less <<
NCT06545695 Epidermolytic Ichthyosis|Palmo... More >>plantar Keratoderma|Pachyonychia Congenita Less << PHASE1|PHASE2 NOT_YET_RECRUITING 2029-06-30 Department of Dermatology, Nor... More >>thwestern University Feinberg School of Medicine, Chicago, Illinois, 60611, United States Less <<
NCT01059305 Skin Cancer PHASE2 TERMINATED 2025-03-16 University of Texas MD Anderso... More >>n Cancer Center, Houston, Texas, 77030, United States Less <<
NCT01247922 Ependymoma PHASE2 TERMINATED 2012-09-13 University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35233, United States|Children's Hospital of Orange County (CHOC), Orange, California, 92868, United States|Packard Children's Hospital, Palo Alto, California, 94304, United States|The Children's Hospital Center for Cancer and Blood Disorders, Aurora, Colorado, 80045, United States|Children's National Medical Center -D.C. Center for Cancer and Blood Disorders, Washington, District of Columbia, 20010, United States|University of Miami, Miami, Florida, 33136, United States|Emory University Children's Healthcare of Atlanta, Atlanta, Georgia, 30322, United States|University of Minnesota - Amplatz Children's Hospital, Minneapolis, Minnesota, 55455, United States|Oregon Health & Sciences University Doernbecher Children's Hospital, Portland, Oregon, 97124, United States|Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania, 15224, United States|University of Wisconsin, Madison, Wisconsin, 53705-2275, United States|Stollery Children's Hospital, Edmonton, Alberta, T6G 2B7, Canada|Children's and Women's Health Center of BC, Vancouver, British Columbia, V6H 3V4, Canada|Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada|Birmingham Children's Hospital Oncology Department, Birmingham, B4 6NH, United Kingdom|Royal Hospital for Sick Children, Glasgow, G3 8SJ, United Kingdom|Paediatric Oncology and Haematology Offices,, Leeds, LS1 3EX, United Kingdom|Alder Hey Children's NHS Foundation Trust, Liverpool, L12 1AP, United Kingdom|Royal Manchester Children's Hospital Ward 84, Manchester, M13 9W2, United Kingdom|University of Nottingham, Nottingham, NG7 2UH, United Kingdom|Royal Marsden Hospital, Sutton, SM2 5pt, United Kingdom Less <<
NCT00977548 Myelodysplastic Syndrome PHASE2 COMPLETED 2025-06-12 H. Lee Moffitt Cancer Center &... More >> Research Institute, Tampa, Florida, 33612, United States Less <<
NCT00570232 Head and Neck Cancer PHASE2 COMPLETED 2025-03-15 University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35233, United States Less <<
NCT02774278 Non-Squamous Non-Small Cell Lu... More >>ng Cancer Less << PHASE2 COMPLETED 2025-06-09 Bruxelles, B-1200, Belgium|Sof... More >>ia, 1756, Bulgaria|Tallin, 11619, Estonia|Tartu, 51014, Estonia|Montpellier, 34295, France|Paris, 75970, France|Grosshansdorf, 22927, Germany|K?ln, 50937, Germany|Hong Kong, Hong Kong|Dublin, 8, Ireland|Perugia, 06132, Italy|Gdansk, 80-214, Poland|Lodz, 94-306, Poland|Lublin, 20-950, Poland|Poznan, 60-569, Poland|Moscow, 105229, Russian Federation|Moscow, 107005, Russian Federation|Moscow, 115478, Russian Federation|St Petersburg, 197089, Russian Federation|St Petersburg, 197758, Russian Federation|St Petersburg, 198255, Russian Federation|Singapore, 169610, Singapore|Barcelona, 08035, Spain|Barcelona, 08916, Spain|Madrid, 28041, Spain|Taipei, 00112, Taiwan|Taipei, 105, Taiwan|Taipei, 106, Taiwan|Weston Super Mare, BS23 4TQ, United Kingdom Less <<
NCT00339586 Lung Neoplasms|Non-Small Cell ... More >>Lung Cancer|Adenocarcinoma, Bronchiolo-Alveolar Less << PHASE2 UNKNOWN - AZ VUB, Jette, 1090, Belgium
NCT00949910 Non-Small Cell Lung Cancer PHASE4 COMPLETED 2025-04-09 Tirana, 1000, Albania|Buenos A... More >>ires, 1272, Argentina|Buenos Aires, 1427, Argentina|Buenos Aires, 1437, Argentina|Buenos Aires, C1405CBA, Argentina|Buenos Aires, C1430BKO, Argentina|Córdoba, 5000, Argentina|La Plata, B1902CMK, Argentina|Salta, 4400, Argentina|Santa Fe, 03000, Argentina|Adelaide, 5011, Australia|Camperdown, 2050, Australia|Chermside, 4032, Australia|Frankston, 3199, Australia|Fremantle, 6160, Australia|Geelong, 3220, Australia|Kurralta Park, 5037, Australia|Malvern, 3144, Australia|Melbourne, 3002, Australia|Melbourne, 3084, Australia|Perth, 6009, Australia|St. Leonards, 2065, Australia|Sydney, 2031, Australia|Sydney, 2217, Australia|Tugun, 4224, Australia|Waratah, 2298, Australia|Wodonga, 3690, Australia|Wollongong, 2500, Australia|Bludesch, 6712, Austria|Grimmenstein, 2840, Austria|Innsbruck, 6020, Austria|Klagenfurt, 9010, Austria|Kufstein, 6330, Austria|Leoben, 8700, Austria|Linz, 4010, Austria|Linz, 4020, Austria|Natters, 6161, Austria|Oberpullendorf, 7350, Austria|Salzburg, 5020, Austria|Wels, 4600, Austria|Wien, 1090, Austria|Wien, 1130, Austria|Wien, 1140, Austria|Wien, 1145, Austria|Wien, 1160, Austria|Zams, 6511, Austria|Aalst, 9300, Belgium|Antwerpen, 2018, Belgium|Antwerpen, 2020, Belgium|Antwerpen, 2060, Belgium|Arlon, 6700, Belgium|Baudour, 7331, Belgium|Blankenberge, 8370, Belgium|Borgerhout, 2140, Belgium|Boussu, 7360, Belgium|Brasschaat, 2930, Belgium|Bruxelles, 1000, Belgium|Bruxelles, 1020, Belgium|Bruxelles, 1070, Belgium|Bruxelles, 1090, Belgium|Bruxelles, 1200, Belgium|Charleroi, 6000, Belgium|Edegem, 2650, Belgium|Genk, 3600, Belgium|Gent, 9000, Belgium|Gilly, 6060, Belgium|Godinne, 5530, Belgium|Gosselies, 6041, Belgium|Haine-saint-paul, 7100, Belgium|Hasselt, 3500, Belgium|Kortrijk, 8500, Belgium|Libramont, 6800, Belgium|Liege, 4000, Belgium|Mons, 7000, Belgium|Namur, 5000, Belgium|Oostende, 8400, Belgium|Ottignies, 1340, Belgium|Oudenaarde, 9700, Belgium|Roeselare, 8800, Belgium|Sint-niklaas, 9100, Belgium|Tielt, 8700, Belgium|Tournai, 7500, Belgium|Turnhout, 2300, Belgium|Wilrijk, 2610, Belgium|Banja Luka, 78000, Bosnia and Herzegovina|Sarajevo, 71000, Bosnia and Herzegovina|Belo Horizonte, 30140-083, Brazil|Belo Horizonte, 30150-221, Brazil|Belo Horizonte, 30150-320, Brazil|Belo Horizonte, 30180-061, Brazil|Brasilia, 70390-150, Brazil|Brasilia, 70710-904, Brazil|Campinas, 13073-400, Brazil|Campinas, 13084-759, Brazil|Caxias do Sul, 95020-450, Brazil|Curitiba, 80440-080, Brazil|Curitiba, 80530-010, Brazil|Curitiba, 80730-180, Brazil|Fortaleza, 60125-151, Brazil|Fortaleza, 60336-550, Brazil|Fortaleza, 60741-420, Brazil|Ijui, 98700-000, Brazil|Jaú, 17210-080, Brazil|Joao Pessoa, 58040280, Brazil|Porto Alegre, 90035-001, Brazil|Porto Alegre, 90110-270, Brazil|Porto Alegre, 90480-003, Brazil|Porto Alegre, 90610-000, Brazil|Recife, 52012-220, Brazil|Ribeirao Preto, 14025-430, Brazil|Rio de Janeiro, 22031072, Brazil|Rio de Janeiro, 22260-020, Brazil|Rio de Janeiro, 22359-900, Brazil|Rio de Janeiro, 22410-003, Brazil|Salvador, 40170-110, Brazil|Salvador, 41810-012, Brazil|Salvador, 41950-610, Brazil|Santos, 11075-350, Brazil|Sao Paulo, 01232-010, Brazil|Sao Paulo, 01308-000, Brazil|Sao Paulo, 01308-050, Brazil|Sao Paulo, 01332-000, Brazil|Sao Paulo, 01406100, Brazil|Sao Paulo, 01509-010, Brazil|Sao Paulo, 01509-900, Brazil|Sao Paulo, 04002-030, Brazil|Sao Paulo, 04122-000, Brazil|Sao Paulo, 04521-022, Brazil|Sao Paulo, 05401-400, Brazil|Sao Paulo, 05651-901, Brazil|Sorocaba, 18035-300, Brazil|Plovdiv, 4004, Bulgaria|Sofia, 1527, Bulgaria|Sofia, 1756, Bulgaria|Sofia, 1784, Bulgaria|Varna, 9010, Bulgaria|Santiago, Chile|Beijing, 100021, China|Beijing, 100053, China|Beijing, 100730, China|Beijing, 101149, China|Chengdu, 610041, China|Guangzhou, 510060, China|Guangzhou, 510080, China|Hangzhou, 310022, China|Harbin, 150040, China|Nanjing, 210002, China|Shanghai, 200030, China|Shanghai, 200032, China|Shanghai, 200433, China|Tianjin, 300060, China|Wuhan, 430030, China|Bogota, Colombia|Cali, Colombia|Zagreb, 10000, Croatia|Brno, 639 00, Czech Republic|Hradec Kralove, 500 05, Czech Republic|Olomouc, 775 20, Czech Republic|Plzen, 305 99, Czech Republic|Praha, 180 00, Czech Republic|Guayaquil, Ecuador|Quito, 2569, Ecuador|Cairo, 11796, Egypt|Giza, 12568, Egypt|Giza, Egypt|Tallin, 11619, Estonia|Tartu, 50406, Estonia|Haemeenlinna, 13530, Finland|Helsinki, 00150, Finland|Helsinki, 00290, Finland|Joensuu, 80210, Finland|Kuopio, 70211, Finland|Oulu, 90029, Finland|Pori, 28500, Finland|Tampere, 33520, Finland|Turku, 20520, Finland|Vaasa, 65130, Finland|Amberg, 92224, Germany|Augsburg, 86150, Germany|Aurich, 26603, Germany|Bad Berka, 99437, Germany|Berlin, 12203, Germany|Berlin, 13125, Germany|Berlin, 13353, Germany|Bonn, 53113, Germany|Celle, 29221, Germany|Dortmund, 44137, Germany|Dresden, 01219, Germany|Essen, 45122, Germany|Flensburg, 24939, Germany|Frankfurt Am Main, 65929, Germany|Frankfurt, 60488, Germany|Freiburg, 79106, Germany|Gauting, 82131, Germany|Gerlingen, 70839, Germany|Giessen, 35392, Germany|Grosshansdorf, 22927, Germany|Halle (saale), 06120, Germany|Hamburg, 20246, Germany|Hamburg, 22767, Germany|Heidelberg, 69126, Germany|Herne, 44625, Germany|Homburg/Saar, 66424, Germany|Kassel, 34125, Germany|Koblenz, 56073, Germany|K?ln, 50677, Germany|K?ln, 51109, Germany|Leipzig, 04207, Germany|Leverkusen, 51375, Germany|Lostau, 39291, Germany|L?wenstein, 74245, Germany|Lübeck, 23562, Germany|Mainz, 55101, Germany|Mannheim, 68167, Germany|Minden, 32429, Germany|Muenchen, 80336, Germany|M?nchengladbach, 41063, Germany|München, 81675, Germany|München, 81737, Germany|Neuruppin, 16816, Germany|Nürnberg, 90419, Germany|Oldenburg, 26121, Germany|Osnabrück, 49076, Germany|Rostock, 18055, Germany|Saarbruecken, 66113, Germany|Trier, 54290, Germany|Ulm, 89081, Germany|Wangen, 88239, Germany|Wiesbaden, 65199, Germany|Wuerselen, 52146, Germany|Wuppertal, 42283, Germany|Athens, 11522, Greece|Athens, 13122, Greece|Athens, 15123, Greece|Haidari, 124.61, Greece|Heraklion, 71110, Greece|Neo Faliro, 18574, Greece|Thessaloniki, 54639, Greece|Thessaloniki, 56429, Greece|Thessaloniki, 57001, Greece|Guatemala City, 01015, Guatemala|Hong Kong, 852, Hong Kong|Hong Kong, Hong Kong|Budapest, 1122, Hungary|Budapest, 1125, Hungary|Budapest, 1529, Hungary|Deszk, 6772, Hungary|Kecskemet, 6000, Hungary|Mátraháza, 3233, Hungary|Nyíregyháza, 4400, Hungary|Pecs, 7635, Hungary|Torokbalint, 2045, Hungary|Bangalore, 560 076, India|New Delhi, 110085, India|New Delhi, 201 301, India|Pune, 411 001, India|Vellore, 632 004, India|Jakarta, 12940, Indonesia|Cork, Ireland|Dublin, 7, Ireland|Dublin, 8, Ireland|Dublin, 9, Ireland|Dublin, Ireland|Galway, Ireland|Ashkelon, 78306, Israel|Beer Sheva, 8410101, Israel|Haifa, 34354, Israel|Haifa, 35152, Israel|Holon, 58100, Israel|Jerusalem, 91031, Israel|Jerusalem, 91120, Israel|Kfar Saba, 44281, Israel|Nahariya, 22100, Israel|Petach Tikva, 49100, Israel|Ramat-gan, 52621, Israel|Rehovot, 76100, Israel|Safed, 13110, Israel|Tel Aviv, 6423906, Israel|Zerifin, 70300, Israel|Ancona, 60121, Italy|Avellino, 83100, Italy|Aviano, 33081, Italy|Bari, 70124, Italy|Benevento, 82100, Italy|Bergamo, 24128, Italy|Bollate, 20021, Italy|Bologna, 40138, Italy|Bologna, 40139, Italy|Brescia, 25123, Italy|Candiolo, 10060, Italy|Catania, 95100, Italy|Catanzaro, 88100, Italy|Cosenza, 87100, Italy|Cuneo, 12100, Italy|Fabriano, 60044, Italy|Feltre - Bl, 32032, Italy|Firenze, 50139, Italy|Genova, 16132, Italy|La Spezia, 19100, Italy|Lido di Camaiore, 55043, Italy|Livorno, 57100, Italy|Meldola, 47014, Italy|Messina, 98123, Italy|Milano, 20133, Italy|Milano, 20157, Italy|Milano, 20162, Italy|Mirano, 30035, Italy|Modena, 41100, Italy|Napoli, 80131, Italy|Napoli, Italy|Nuoro, 081100, Italy|Orbassano, 10043, Italy|Palermo, 90123, Italy|Palermo, 90127, Italy|Parma, 43100, Italy|Pavia, 27100, Italy|Perugia, 06122, Italy|Pescara, 65124, Italy|Pisa, 56100, Italy|Rionero in Vulture, 85028, Italy|Roma, 00144, Italy|Roma, 00152, Italy|Roma, 00157, Italy|Roma, 00168, Italy|Roma, 00186, Italy|Roma, 00189, Italy|Salerno, 80124, Italy|Salerno, 84131, Italy|San Giovanni Rotondo, 71013, Italy|Sassari, 07100, Italy|Siena, 53100, Italy|Sondrio, 23100, Italy|Taormina, 98030, Italy|Torino, 10126, Italy|Trento, 38100, Italy|Udine, 33100, Italy|Bundang City, 463-802, Korea, Republic of|Busan, 602-715, Korea, Republic of|Cheonan, 330-715, Korea, Republic of|Daegu, 700-712, Korea, Republic of|Daegu, 700-721, Korea, Republic of|Daegu, 705-717, Korea, Republic of|Daejeon, 301-721, Korea, Republic of|Gwangju, 501-757, Korea, Republic of|Iksan, 570-711, Korea, Republic of|Incheon, 400-711, Korea, Republic of|Kyunggi-do, 411-769, Korea, Republic of|Pusan, 602-702, Korea, Republic of|Pusan, 602-739, Korea, Republic of|Pusan, 614-735, Korea, Republic of|Seoul, 133-792, Korea, Republic of|Seoul, 135-170, Korea, Republic of|Seoul, 135-720, Korea, Republic of|Seoul, 136-705, Korea, Republic of|Seoul, 137-040, Korea, Republic of|Seoul, 138-736, Korea, Republic of|Seoul, 139-706, Korea, Republic of|Seoul, 158-710, Korea, Republic of|Seoul, 405-760, Korea, Republic of|Suwon, 442-721, Korea, Republic of|Riga, LV 1079, Latvia|Riga, LV-1002, Latvia|Kaunas, 50009, Lithuania|Vilnius, 08660, Lithuania|Kuala Lumpur, 59100, Malaysia|Acapulco, 39850, Mexico|Chihuahua, 31000, Mexico|Chihuahua, 31238, Mexico|Guadalajara, 44220, Mexico|Guadalajara, 44340, Mexico|Juarez, 32310, Mexico|Leon, 37000, Mexico|Leon, 37160, Mexico|Matamoros, 87300, Mexico|Merida, 97070, Mexico|Merida, 97150, Mexico|Mexicali, 21100, Mexico|Mexico City, 01120, Mexico|Mexico City, 03100, Mexico|Mexico City, 06700, Mexico|Mexico City, 06720, Mexico|Mexico City, 07360, Mexico|Mexico City, 11850, Mexico|Mexico City, 14050, Mexico|Mexico City, 14080, Mexico|Mexico City, 72530, Mexico|Mexico City, 89400, Mexico|Monterrey, 64020, Mexico|Monterrey, 64060, Mexico|Monterrey, 64320, Mexico|Monterrey, 64380, Mexico|Obregon, 85000, Mexico|Obregon, 85100, Mexico|Puebla, 72530, Mexico|San Luis Potosi, 78230, Mexico|Tampico, 89120, Mexico|Tijuana, 22320, Mexico|Toluca, 52140, Mexico|Torreon, 27200, Mexico|Zapopan, 44349, Mexico|'s Hertogenbosch, 5211 RW, Netherlands|Alkmaar, 1815 JD, Netherlands|Amersfoort, 3818 ES, Netherlands|Amstelveen, 1186 AH, Netherlands|Amsterdam, 1007 MB, Netherlands|Amsterdam, 1061 AE, Netherlands|Amsterdam, 1066 CX, Netherlands|Amsterdam, 1091 AC, Netherlands|Amsterdam, 1105 AZ, Netherlands|Arnhem, 6815 AD, Netherlands|Assen, 9401 RK, Netherlands|Beverwijk, 1942 LE, Netherlands|Boxmeer, 5831 HA, Netherlands|Breda, 4819 EV, Netherlands|Capelle Ad Yssel, 2906 ZC, Netherlands|Den Haag, 2504 LN, Netherlands|Drachten, 9202 NN, Netherlands|Eindhoven, 5623 EJ, Netherlands|Enschede, 7513 ER, Netherlands|Groningen, 9713 GZ, Netherlands|Groningen, 9728 NZ, Netherlands|Haarlem, 2035 RC, Netherlands|Harderwijk, 3844 DG, Netherlands|Heerlen, 6419 PC, Netherlands|Helmond, 5700 AB, Netherlands|Hengelo, 7555 DL, Netherlands|Hoofddorp, 2134 TM, Netherlands|Leiden, 2333 ZA, Netherlands|Leiderdorp, 2353 GA, Netherlands|Maastricht, 6229 HX, Netherlands|Nieuwegein, 3435 CM, Netherlands|Nijmegen, 6532 SZ, Netherlands|Roermond, 6043 CV, Netherlands|Rotterdam, 3045 PM, Netherlands|Sliedrecht, 3361 XV, Netherlands|Veldhoven, 5504 DB, Netherlands|Venlo, 5912 BL, Netherlands|Vlaardingen, 3136 LA, Netherlands|Vlissingen, 4382 EE, Netherlands|Zaandam, 1502 DV, Netherlands|Zwolle, 8011 JW, Netherlands|Christchurch, New Zealand|Hamilton, 3240, New Zealand|Palmerston North, New Zealand|Wellington, 6002, New Zealand|Panama City, 0, Panama|Callao, Peru|Lima, 11, Peru|Lima, 13, Peru|Lima, 18, Peru|Gdansk, 80-214, Poland|Lublin, 20-090, Poland|Olsztyn, 10-228, Poland|Poznan, 60-569, Poland|Warszawa, 01-138, Poland|Warszawa, 02-781, Poland|Wroclaw, 53-439, Poland|Zabrze, 41-843, Poland|Lisboa, 1600, Portugal|Porto, 4200-072, Portugal|Setubal, 2910-446, Portugal|S?o Martinho do Bispo, 3041, Portugal|Vila Nova de Gaia, 4400-129, Portugal|Alba Iulia, 510073, Romania|Baia Mare, Romania|Bucharest, 010816, Romania|Bucharest, 022328, Romania|Bucharest, Romania|Cluj Napoca, 400015, Romania|Oradea, Romania|Sibiu, Romania|Suceava, Romania|Timisoara, 1900, Romania|Barnaul, 656049, Russian Federation|Kazan, 420029, Russian Federation|Kazan, 420111, Russian Federation|Krasnodar, 350040, Russian Federation|Krasnodar, Russian Federation|Moscow, 107005, Russian Federation|Moscow, 115478, Russian Federation|Moscow, 143423, Russian Federation|Obninsk, 249036, Russian Federation|Samara, 443031, Russian Federation|Smolensk, 214000, Russian Federation|St Petersburg, 197022, Russian Federation|St Petersburg, 197758, Russian Federation|Stavropol, 355047, Russian Federation|Tumen, 625047, Russian Federation|Ufa, 450054, Russian Federation|Volgograd, 400138, Russian Federation|Riyadh, 11426, Saudi Arabia|Belgrade, 11000, Serbia|Novi Sad, 21000, Serbia|Banska Bystrica, 975 17, Slovakia|Bratislava, 825 56, Slovakia|Kosice, 041 90, Slovakia|Nitra, 949 88, Slovakia|Poprad, 058 87, Slovakia|Ljubljana, 1000, Slovenia|Falun, 79182, Sweden|Goeteborg, 41345, Sweden|G?teborg, 41345, Sweden|Linkoeping, 58185, Sweden|Lund, 22185, Sweden|Malmoe, 20502, Sweden|Stockholm, 17176, Sweden|Uppsala, 75185, Sweden|Aarau, 5000, Switzerland|Aarau, 5001, Switzerland|Baden, 5404, Switzerland|Chur, 7000, Switzerland|Locarno, 6601, Switzerland|Luzern, 6004, Switzerland|Zürich, 8091, Switzerland|Changhua, 500, Taiwan|Kaohsiung, 00833, Taiwan|Kaohsiung, 807, Taiwan|Kaohsiung, 813, Taiwan|Taichung, 404, Taiwan|Taichung, 407, Taiwan|Tainan, 704, Taiwan|Tainan, 710, Taiwan|Taipei, 00112, Taiwan|Taipei, 104, Taiwan|Taipei, 106, Taiwan|Taipei, 112, Taiwan|Taipei, 114, Taiwan|Taoyuan, 333, Taiwan|Bangkok, 10110, Thailand|Bangkok, 10330, Thailand|Bangkok, 10700, Thailand|Ankara, 06018, Turkey|Ankara, 06100, Turkey|Ankara, 06500, Turkey|Ankara, 06590, Turkey|Istanbul, 34300, Turkey|Istanbul, 34890, Turkey|Istanbul, Turkey|Izmir, 35100, Turkey|Izmir, 35340, Turkey|Shhiye, Ankara, 06100, Turkey|Montevideo, 11600, Uruguay|Caracas, 1020, Venezuela|Caracas, 1060, Venezuela Less <<
NCT01230710 Non-Small Cell Lung Cancer PHASE4 COMPLETED 2025-09-13 Bangalore, 560027, India|Chenn... More >>ai, 600035, India|Delhi, 110085, India|Hyderabad, 500 034, India|Jaipur, 302 017, India|Kolkata, 700026, India|Nasik, 422005, India Less <<
NCT00997334 Non-small Cell Lung Cancer PHASE2 COMPLETED 2025-01-17 Beth Israel Deaconess Medical ... More >>Center, Boston, Massachusetts, 02115, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, United States Less <<
NCT00830245 Leptomeningeal Carcinomatosis|... More >>Non-small Cell Lung Cancer Less << PHASE2 TERMINATED 2025-07-11 Dae Seog Heo, Seoul, Korea, Re... More >>public of Less <<
NCT01161173 Nonsquamous Nonsmall Cell Neop... More >>lasm of Lung Less << COMPLETED 2025-08-12 Aalst, 9300, Belgium|Antwerpen... More >>, 2020, Belgium|Arlon, 6700, Belgium|Bonheiden, 2820, Belgium|Bouge, 5004, Belgium|Boussu, 7360, Belgium|Bruxelles, 1020, Belgium|Bruxelles, 1050, Belgium|Bruxelles, 1180, Belgium|Bruxelles, 1200, Belgium|Charleroi, 6000, Belgium|Chimay, 6460, Belgium|Duffel, 2570, Belgium|Edegem, 2650, Belgium|Frameries, 7080, Belgium|Genk, 3600, Belgium|Gilly, 6060, Belgium|Hasselt, 3500, Belgium|Leuven, 3000, Belgium|Liege, 4000, Belgium|Liège, 4000, Belgium|Marche-En-Famenne, 5411, Belgium|Mons, 7000, Belgium|Namur, 5000, Belgium|Oostende, 8400, Belgium|Ottignies, 1340, Belgium|Roeselare, 8800, Belgium|Seraing, 4100, Belgium|Sint Niklaas, 9100, Belgium|Tournai, 7500, Belgium|Turnhout, 2300, Belgium|Verviers, 4800, Belgium|Vilvoorde, 1800, Belgium|Wilrijk, 2610, Belgium|Differdange, 4602, Luxembourg|Esch-alzette, Luxembourg|Luxembourg, 1210, Luxembourg Less <<
NCT00137839 Adenocarcinoma|Non-small Cell ... More >>Lung Cancer Less << PHASE2 COMPLETED 2025-07-19 Massachusetts General Hospital... More >>, Boston, Massachusetts, 02114, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02115, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, United States Less <<
NCT01038856 Polycythemia Vera PHASE2 TERMINATED 2025-02-14 University of Oklahoma Health ... More >>Sciences Center, Oklahoma City, Oklahoma, 73104, United States Less <<
NCT00476476 Squamous Cell Carcinoma PHASE2 COMPLETED 2025-10-12 Beth Israel Deaconess Medical ... More >>Center, Boston, Massachusetts, 02115, United States|Massachusetts General Hospital, Boston, Massachusetts, 02214, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02215, United States|Women and Infants Hospital of Rhode Island, Providence, Rhode Island, 02905, United States Less <<
NCT01198028 Metastatic Skin Squamous Cell ... More >>Carcinoma|Recurrent Skin Squamous Cell Carcinoma Less << PHASE2 COMPLETED 2019-05-01 M D Anderson Cancer Center, Ho... More >>uston, Texas, 77030, United States Less <<
NCT01320501 Non-small Cell Lung Cancer Met... More >>astatic Less << PHASE4 SUSPENDED 2025-08-16 King Abdul Aziz Medical City f... More >>or National Guard Health Affairs, Riyadh, 11426, Saudi Arabia Less <<
NCT00045487 Kidney Cancer PHASE2 COMPLETED 2025-05-08 University of Texas Health Sci... More >>ence Center San Antonio, San Antonio, Texas, 78229, United States Less <<
NCT01153984 Carcinoma,Non-Small-Cell Lung PHASE2 COMPLETED 2025-07-15 County Hospital Alba; Oncology... More >>, Alba Iulia, 510073, Romania|Institute Of Oncology Bucharest; Medical Oncology, Bucharest, 022338, Romania|Spitalul de Boli Cronice Sf. Luca, Bucharest, 04195, Romania|Emergency University Bucharest Hospital; Oncology Department, Bucharest, 050098, Romania|Institut of Oncology Al. Trestioreanu Bucharest; Oncology, Bucuresti, 022328, Romania|Oncology Inst. Cluj-Napoca; Cancer Dept, Cluj-Napoca, 400015, Romania|Uni Hospital St. Spiridon; Clinica Oncologie-Radiotherapie, Iasi, 6600, Romania|S.C. Life Search S.R.L; Medical Oncology Clinic, Timisoara, 300167, Romania|ONCOMED - Medical Centre, Timisoara, 300239, Romania Less <<
NCT00497224 Cancer|Pancreas PHASE2 COMPLETED 2025-06-13 Tom Baker Cancer Centre, Calga... More >>ry, Alberta, T2N 4N2, Canada|Cross Cancer Institute, Edmonton, Alberta, T6G 1Z2, Canada|British Columbia Cancer Agency, Vancouver, British Columbia, V5Z 4E6, Canada|CancerCare Manitoba, Winnipeg, Manitoba, R2H 2A6, Canada|Princess Margaret Hospital, Toronto, Ontario, M5G 2M9, Canada Less <<
NCT00369512 Cancer PHASE2 COMPLETED 2025-09-12 University of Alabama at Birmi... More >>ngham Medical Center, Birmingham, Alabama, 35233, United States Less <<
NCT01990261 Non-Squamous Non-Small Cell Lu... More >>ng Cancer Less << TERMINATED 2025-09-14 Bucharest, 022338, Romania
NCT02140333 NSCLC|EGFR Mutation PHASE3 UNKNOWN 2025-12-18 Guangzhou medical university, ... More >>Guanzhou, Guangdong, 510120, China Less <<
NCT00567359 Non-small Cell Lung Cancer PHASE2 COMPLETED 2025-12-17 Stanford University, Stanford,... More >> California, 94305, United States|Massachusetts General Hosptial, Boston, Massachusetts, 02114, United States|Beth Israel Deaconess Medical Center, Boston, Massachusetts, 02115, United States|Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, United States|North Shore Medical Center, Peabody, Massachusetts, 01960, United States|Washington University School of Medicine, Saint Louis, Missouri, 63110, United States|Memorial Sloan Kettering Cancer Center, New York, New York, 10021, United States|Taussig Cancer Center, Cleveland, Ohio, 44195, United States Less <<
NCT01297101 Non-small Cell Lung Cancer TEMPORARILY_NOT_AVAILABLE - -
NCT01085838 Myelodysplastic Syndrome PHASE1|PHASE2 COMPLETED 2025-03-14 CHU d'Angers, Angers, 49033, F... More >>rance|H?pital Avicenne, Bobigny, 93009, France|Centre Hospitalier du Mans, Le Mans cedex, 72037, France|CHRU Huriez, Lille, 59037, France|CHRU de Limoges, Limoges, 87046, France|Centre Hospitalier Lyon Sud, Lyon, 69495, France|Institut Paoli-Calmettes, Marseille, 13273, France|CHU Nantes, Nantes, 44093, France|CHU Caremeau, Nimes, 30029, France|Hopital St Louis, Paris, 75475, France|Hopital Cochin, Paris, 75679, France|Hopital Purpan-Medecine interne, Toulouse, 31059, France|Hopital Purpan, Toulouse, France|Institut Gustave Roussy, Villejuif, 94805, France Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.54mL

0.51mL

0.25mL

12.71mL

2.54mL

1.27mL

25.42mL

5.08mL

2.54mL

References

 

Historical Records

Categories