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Chemical Structure| 140-67-0 Chemical Structure| 140-67-0
Chemical Structure| 140-67-0

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Estragole (4-Allylanisole), a relatively nontoxic volatile terpenoid ether, is a major component of the essential oil of many plants. Estragole dose-dependently blocks nerve excitability. Estragole displays anti-toxoplasma activity.

Synonyms: 4-Allylanisole; Methyl Chavicol; NSC 404113

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Product Details of Estragole

CAS No. :140-67-0
Formula : C10H12O
M.W : 148.20
SMILES Code : COC1=CC=C(CC=C)C=C1
Synonyms :
4-Allylanisole; Methyl Chavicol; NSC 404113
MDL No. :MFCD00008653
InChI Key :ZFMSMUAANRJZFM-UHFFFAOYSA-N
Pubchem ID :8815

Safety of Estragole

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H351-H361
Precautionary Statements:P301+P312+P330

Application In Synthesis of Estragole

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 140-67-0 ]

[ 140-67-0 ] Synthesis Path-Downstream   1~6

  • 2
  • [ 104-21-2 ]
  • [ 762-72-1 ]
  • [ 140-67-0 ]
  • 3
  • [ 140-67-0 ]
  • [ 147751-16-4 ]
  • [ 1239668-96-2 ]
  • 4
  • [ 140-67-0 ]
  • [ 570-02-5 ]
  • (E)-1,3,5-trimethoxy-2-(3-(4-methoxyphenyl)prop-1-en-1-yl)benzene [ No CAS ]
YieldReaction ConditionsOperation in experiment
87% With palladium(II) trifluoroacetate; silver carbonate; In tetrahydrofuran; dimethyl sulfoxide; at 100℃; for 8h;Inert atmosphere; General procedure: To an oven-dried pressure tube were sequentially added aryl carboxylic acid 1 (0.2 mmol), olefin 2 (0.24 mmol), Pd(TFA)2 (3.33 mg, 5.0 mol%), Ag2CO3 (55.2 mg, 0.2 mmol), THF (2.0 mL) and DMSO (0.10 mL) under nitrogen at room temperature. After degassing three times, the reaction mixture was heated at 100 C for 8 h, and then was cooled to room temperature. Water (20.0 mL)was added, and the mixture was extracted with ethyl acetate (3 5.0 mL). The combined organic layer was washed with brine, dried over anhydrious Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluant: hexane/ethyl acetate) to give the pure target product.
  • 5
  • [ 198477-89-3 ]
  • [ 140-67-0 ]
  • [ 230299-21-5 ]
  • C24H30BFO4 [ No CAS ]
  • 1-(2-fluoro-5-(1-(4-methoxyphenyl)-3-(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)propyl)phenyl)ethan-1-one [ No CAS ]
  • 6
  • [ 140-67-0 ]
  • [ 230299-21-5 ]
  • [ 407-14-7 ]
  • 2-(3-(4-methoxyphenyl)-3-(4-(trifluoromethoxy)phenyl)propyl)-4,4,6-trimethyl-1,3,2-dioxaborinane [ No CAS ]
 

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