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Chemical Structure| 30544-47-9 Chemical Structure| 30544-47-9

Structure of Etofenamate
CAS No.: 30544-47-9

Chemical Structure| 30544-47-9

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Etofenamate is a non-steroidal anti-inflammatory drug used for the treatment joint and muscular pain.

Synonyms: Etofenamate

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Product Details of Etofenamate

CAS No. :30544-47-9
Formula : C18H18F3NO4
M.W : 369.34
SMILES Code : OCCOCCOC(C1=C(C=CC=C1)NC2=CC=CC(C(F)(F)F)=C2)=O
Synonyms :
Etofenamate
MDL No. :MFCD00242806
InChI Key :XILVEPYQJIOVNB-UHFFFAOYSA-N
Pubchem ID :35375

Safety of Etofenamate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00530387 Dermatitis, Photocontact Not Applicable Completed - United Kingdom ... More >> Photobiology Unit, Ninewells Hospital, Dundee, Angus, United Kingdom, DD1 9SY Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.71mL

0.54mL

0.27mL

13.54mL

2.71mL

1.35mL

27.08mL

5.42mL

2.71mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

[1]Fraga A, de Almeida M, et al. Intramuscular Etofenamate versus Diclofenac in the Relief of Renal Colic : A Randomised, Single-Blind, Comparative Study. Clin Drug Investig. 2003;23(11):701-6.

[2]Bender T, Bariska J, et al. Etofenamate levels in human serum and synovial fluid following iontophoresis. Arzneimittelforschung. 2001;51(6):489-92.

[3]Fraga A, de Almeida M, Moreira-da-Silva V, Sousa-Marques M, Severo L, Matos-Ferreira A, Campos-Pinheiro L, Reis M, Ribau U, Silveira P, Almeida L. Intramuscular Etofenamate versus Diclofenac in the Relief of Renal Colic : A Randomised, Single-Blind, Comparative Study. Clin Drug Investig. 2003;23(11):701-6

[4]Marinho ODS, Pereira A. Clinical Efficacy and Safety Profile of Topical Etofenamate in the Treatment of Patients with Musculoskeletal Disorders: A Systematic Review. Pain Ther. 2020 Dec;9(2):393-410

[5]Patiñio JL, Mejía SN, Ramos EQ. Efecto analgésico del etofenamato en el manejo de las lumbalgias agudas en urgencias [Etofenamate and the analgesic effect in the management of acute pain from spine in the emergency room]. Acta Ortop Mex. 2007 Sep-Oct;21(5):253-5. Spanish

[6]Rannou F, Pelletier JP, Martel-Pelletier J. Efficacy and safety of topical NSAIDs in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S18-21

[7]Mancini G, Gonçalves LMD, Marto J, Carvalho FA, Simões S, Ribeiro HM, Almeida AJ. Increased Therapeutic Efficacy of SLN Containing Etofenamate and Ibuprofen in Topical Treatment of Inflammation. Pharmaceutics. 2021 Mar 3;13(3):328

 

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