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Chemical Structure| 1256937-27-5 Chemical Structure| 1256937-27-5

Structure of Evolocumab
CAS No.: 1256937-27-5

Chemical Structure| 1256937-27-5

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Evolocumab is a humanized IgG2 monoclonal antibody that prevents PCSK9 from binding to LDL receptors. Evolocumab has potential for research on hypercholesterolemia.

Synonyms: AMG 145

4.5 *For Research Use Only !

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Product Details of Evolocumab

CAS No. :1256937-27-5
M.W : 141.8 kDa
SMILES Code : NONE
Synonyms :
AMG 145

Safety of Evolocumab

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Wistar rats Collagen-induced arthritis (CIA) rat model Intraperitoneal injection 0.1 ml/rat Once a week for 4 weeks To evaluate the effect of Evolocumab on AF susceptibility and atrial structural remodeling in CIA rats. Results showed that Evolocumab reduced AF susceptibility and improved atrial structural remodeling in CIA rats. J Adv Res. 2024 Jul;61:211-221
Mice Abdominal aortic transplantation model Subcutaneous injection 10 mg/kg Every 2 weeks for 8 weeks To evaluate the therapeutic effect of Evolocumab on GVD. Results showed that Evolocumab significantly ameliorated GVD in humanized PCSK9 mice, reducing vascular stenosis and intimal hyperplasia area. Front Immunol. 2022 May 26;13:894789
Mice HPCSK9-KI mouse model Subcutaneous injection 10 mg/kg Single injection, measured after 24 hours To evaluate the effect of evolocumab on cholesterol levels in hPCSK9-KI mice. Results showed that evolocumab significantly reduced plasma total cholesterol levels in hPCSK9-KI mice but had no effect on wildtype mice. BMC Biol. 2019 Jan 15;17(1):4
Mice High-fat diet-induced renal injury model Orbital injection 30 mg/kg Once weekly for 10 days To study the protective effect of evolocumab on high-fat diet-induced renal injury, results showed that evolocumab protected against HFD-induced renal injury by reducing cell surface CD36 expression on renal epithelia. Kidney360. 2022 Apr 27;3(8):1394-1410

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT05697185 Ischemic Stroke, Acute PHASE4 UNKNOWN 2024-12-01 -
NCT03791593 Heart Failure With Reduced Eje... More >>ction Fraction Less << PHASE2 COMPLETED 2022-07-20 Hospital Universitari Germans ... More >>Trias i Pujol, Badalona, Barcelona, 08916, Spain|Hospital Universitario Virgen del Rocío, Sevilla, 41013, Spain|Hospital Clínico de Valencia, Valencia, 46010, Spain Less <<
NCT05152888 Stable Coronary Disease PHASE4 RECRUITING 2025-12-31 Brigham and Women's Hospital, ... More >>Boston, Massachusetts, 02115, United States Less <<
NCT02948777 Type 2 Diabetes Mellitus PHASE4 COMPLETED 2025-06-18 Helsinki University Hospital, ... More >>Biomedicum 2U, Helsinki, Finland Less <<
NCT05579418 STEMI|Dyslipidemias PHASE4 UNKNOWN 2024-10-30 -
NCT03500302 Human Immunodeficiency Virus|C... More >>oronary Artery Disease Less << PHASE2 COMPLETED 2019-11-30 Johns Hopkins University, Balt... More >>imore, Maryland, 21205, United States Less <<
NCT03080935 Dyslipidemia PHASE3 TERMINATED 2022-03-04 Algemeen Stedelijk Ziekenhuis ... More >>Aalst, Aalst, 9300, Belgium|Onze Lieve Vrouw Ziekenhuis Aalst, Aalst, 9300, Belgium|Ziekenhuis Netwerk Antwerpen Middelheim, Antwerpen, 2020, Belgium|Ziekenhuis Netwerk Antwerpen Stuivenberg, Antwerpen, 2060, Belgium|Imelda Ziekenhuis vzw, Bonheiden, 2820, Belgium|Centre Hospitalier Universitaire Brugmann, Brussels, 1020, Belgium|Cliniques universitaires de Bruxelles Hopital Erasme, Brussels, 1070, Belgium|Universite Catholique de Louvain Cliniques Universitaires Saint Luc, Bruxelles, 1200, Belgium|Algemeen Ziekenhuis Sint Lucas, Gent, 9000, Belgium|Universitair Ziekenhuis Gent, Gent, 9000, Belgium|Medif sprl, Gozee, 6534, Belgium|Centre Hospitalier Universitaire de Tivoli, La Louvi?¨re, 7100, Belgium|Centres Hospitaliers Jolimont - Hopital de Jolimont, La Louvi?¨re, 7100, Belgium|Centre Hospitalier Universitaire de Liege - Sart Tilman, Liege, 4000, Belgium|Centre Hospitalier Regional de la Citadelle, Li?¨ge, 4000, Belgium|Algemeen Ziekenhuis Turnhout, Turnhout, 2300, Belgium|Aalborg Hospital, Aalborg, 9000, Denmark|Center for Clinical and Basic Research Aalborg, Aalborg, 9000, Denmark|Aarhus Universitetshospital, Aarhus N, 8200, Denmark|Centre for Clinical and Basic Research Ballerup, Ballerup, 2750, Denmark|Sydvestjysk Sygehus, Esbjerg, 6700, Denmark|Frederiksberg/Bispebjerg Hospitaler, Frederiksberg, 2000, Denmark|Glostrup Hospital, Glostrup, 2600, Denmark|Hvidovre Hospital, Hvidovre, 2650, Denmark|Amager Hospital, Kobenhavn S, 2300, Denmark|Odense Universitetssygehus, Odense, 5000, Denmark|Sjaellands Universitetshospital, Roskilde, Roskilde, 4000, Denmark|Svendborg Sygehus, Svendborg, 5700, Denmark|Center for Clinical and Basic Research Vejle, Vejle, 7100, Denmark|Regionshospitalet Viborg, Viborg, 8800, Denmark|Centre Hospitalier Regional Universitaire de Besancon, Hopital Jean Minjoz, Besancon cedex, 25030, France|Centre Hospitalier R??gional Universitaire de Tours - H?′pital Trousseau, Chambray les Tours, 37170, France|Hopital Louis Pasteur, Le Coudray, 28630, France|Centre Hospitalier Regional Universitaire de Montpellier - Hopital Arnaud de Villeneuve, Montpellier cedex 05, 34295, France|Centre Hospitalier Universitaire de Nantes - Hopital Guillaume et Rene Laennec, Nantes Cedex 1, 44093, France|Nouvelles Cliniques Nantaises, Nantes Cedex 2, 44202, France|Centre Hospitalier Universitaire de Nice - Hopital Pasteur, Nice, 06000, France|Hopital Lariboisiere, Paris, 75010, France|Hopital Pitie-Salpetriere, Paris, 75013, France|Centre Hospitalier de Pau - Hopital Francois Mitterrand, Pau, 64000, France|Centre Hospitalier Universitaire de Reims - Hopital Robert Debre, Reims, 51100, France|Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil, Toulouse Cedex 9, 31059, France|Centre Hospitalier Intercommunal Haute Saone, Vesoul, 70014, France|Universitaets-Herzzentrum Freiburg - Bad Krozingen, Bad Krozingen, 79189, Germany|Klinische Forschung Berlin GbR, Berlin, 10787, Germany|Vivantes Klinikum Neuk??lln, Berlin, 12351, Germany|Deutsches Rotes Kreuz Kliniken Berlin K??penick, Berlin, 12559, Germany|Deutsches Herzzentrum Berlin, Berlin, 13353, Germany|Sankt-Johannes-Hospital, Dortmund, 44137, Germany|Gesellschaft fur Wissens und Technologietransfer der Technischen Uni Dresden, Dresden, 01307, Germany|Ambulantes Herzzentrum Kassel, Kassel, 34121, Germany|Universit?¤tsklinikum K??ln, K??ln, 50937, Germany|Otto von Guericke Universit?¤t Magdeburg, Magdeburg, 39120, Germany|Johannes Gutenberg Universit?¤t Mainz, Mainz, 55131, Germany|Herz-Gef?¤??-Zentrum Nymphenburg am Klinikum Dritter Orden, M??nchen, 80333, Germany|Deutsches Herzzentrum M??nchen des Freistaates Bayern, M??nchen, 80636, Germany|Robert Bosch Krankenhaus, Stuttgart, 70376, Germany|Universit?¤tsklinikum Ulm, Ulm, 89081, Germany|Forschungszentrum Ruhr, Witten, 58455, Germany|Helios Universit?¤tsklinikum Wuppertal, Wuppertal, 42117, Germany|Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, 24127, Italy|Azienda Ospedaliero Universitaria Careggi, Firenze, 50139, Italy|Centro Cardiologico Monzino, Milano, 20138, Italy|Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milano, 20162, Italy|Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello, Palermo, 90146, Italy|Fondazione IRCCS Policlinico San Matteo, Pavia, 27100, Italy|Azienda Ospedaliera di Perugia Ospedale Santa Maria della Misericordia, Perugia, 06129, Italy|Fondazione Toscana Gabriele Monasterio, Stabilimento Ospedaliero di Pisa, Pisa, 56124, Italy|Azienda Ospedaliera Universitaria Senese Policlinico Le Scotte, Siena, 53100, Italy|Hospital Garcia de Orta, EPE, Almada, 2801-951, Portugal|Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, 3000-075, Portugal|Centro Hospitalar Cova da Beira, EPE - Hospital Pero da Covilha, Covilha, 6200-251, Portugal|Hospital Cuf Infante Santo, Lisboa, 1350-352, Portugal|Centro Hospitalar de Lisboa Ocidental, EPE - Hospital Sao Francisco Xavier, Lisboa, 1449-005, Portugal|Centro Hospitalar de Setubal EPE Hospital de Sao Bernardo, Setubal, 2910-446, Portugal|Falu Lasarett, Falun, 791 82, Sweden|Helsingborgs Lasarett, Helsingborg, 252 47, Sweden|L?¤nssjukhuset Ryhov, J??nk??ping, 551 85, Sweden|Sunderby Sjukhus, Lulea, 971 80, Sweden|Skanes Universitetssjukhus, Lund, 221 85, Sweden|Capio Citykliniken, Lund, 222 21, Sweden|Universitetssjukhuset ?-rebro, Orebro, 701 85, Sweden|Ostersunds sjukhus, Ostersund, 831 83, Sweden|Akardo MedSite, Stockholm, 117 27, Sweden|Norrlands Universitetssjukhus, Umea, 901 85, Sweden Less <<
NCT04087915 Dyslipidemia|High Risk Coronar... More >>y Artery Disease Less << UNKNOWN 2021-12-31 Beijing Anzhen Hospital, Capit... More >>al Medical University, Beijing, Beijing, 100029, China Less <<
NCT05418166 Acute Coronary Syndrome UNKNOWN 2022-09-01 the first affiliated hospital ... More >>of Harbin Medical University, Harbin, Heilongjiang, 150000, China Less <<
NCT03247972 Peripheral Arterial Disease TERMINATED 2019-10-01 Inova Fairfax Hospital, Falls ... More >>Church, Virginia, 22042, United States Less <<
NCT03331666 Familial Hypercholesterolemia PHASE4 TERMINATED 2020-02-04 Columbia University Medical Ce... More >>nter, New York, New York, 10032, United States Less <<
NCT03944577 Heart Transplant PHASE2 COMPLETED 2023-03-28 University of Nebraska Medical... More >> Center, Omaha, Nebraska, 68198, United States Less <<
NCT04665830 Kideny Transplant Recipients W... More >>ith High Cardiovascular Risk Score Less << PHASE3 COMPLETED 2020-05-01 OTC, MOH , Kuwait, Kuwait, Kuw... More >>ait, Kuwait Less <<
NCT06140095 Acute Metabolic Effects of Evo... More >>locumab and Atorvastatin Less << EARLY_PHASE1 NOT_YET_RECRUITING 2025-12-25 -
NCT04100434 Acute Coronary Syndrome|Propro... More >>tein Convertase Subtilisin/Kexin Type 9 Inhibitor Less << PHASE4 UNKNOWN 2023-06-01 Tianjin Chest Hospital,, Tianj... More >>in, 300222, China Less <<
NCT06231459 Hypercholesterolemia, Familial PHASE4 COMPLETED 2020-12-31 National Medical Center "20 de... More >> Noviembre", ISSSTE, Mexico City, 03100, Mexico Less <<
NCT04313270 Hypercholesterolemia, Familial RECRUITING 2025-12-01 Matteo Di Minno, Napoli, 80131... More >>, Italy Less <<
NCT04937413 Malignant Glioma|Glioblastoma EARLY_PHASE1 COMPLETED 2023-10-12 Duke University Medical Center... More >>, Durham, North Carolina, 27710, United States Less <<
NCT04539223 Carotid Artery Stenosis|Asympt... More >>omatic Carotid Artery Stenosis Less << PHASE4 UNKNOWN 2025-05-22 North York Diagnostic and Card... More >>iac Centre, North York, Ontario, M6B 3H7, Canada|East Toronto Vascular Clinic, Toronto, Ontario, M4L3Y3, Canada|St. Michael's Hospital, Toronto, Ontario, Canada Less <<
 

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