Structure of Famciclovir
CAS No.: 104227-87-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Famciclovir is a guanine analogue antiviral drug as it is a competitive inhibitor of herpes simplex 2 DNA polymerase.
Synonyms: BRL 42810
4.5
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
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CAS No. : | 104227-87-4 |
Formula : | C14H19N5O4 |
M.W : | 321.33 |
SMILES Code : | NC1=NC=C2N=CN(CCC(COC(C)=O)COC(C)=O)C2=N1 |
Synonyms : |
BRL 42810
|
MDL No. : | MFCD00866964 |
InChI Key : | GGXKWVWZWMLJEH-UHFFFAOYSA-N |
Pubchem ID : | 3324 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H302 |
Precautionary Statements: | P280-P305+P351+P338 |
In Vitro:
Cell Line
|
Concentration | Treated Time | Description | References |
HT-29 | 959 µM | 48 h | To evaluate the cytotoxic effect of Famciclovir on HT-29 cells, the results showed an IC10 value of 959 µM. | PMC10962075 |
HCT-116 | 422 µM | 48 h | To evaluate the cytotoxic effect of Famciclovir on HCT-116 cells, the results showed an IC10 value of 422 µM. | PMC10962075 |
In Vivo:
Species
|
Animal Model
|
Administration | Dosage | Frequency | Description | References |
BALB/c female mice | HSV-2 cutaneous infection model | Oral gavage | 50 mg/kg | Twice daily, from 22 h postinfection to day 5.5 | Compare the therapeutic effects of famciclovir and valaciclovir on HSV-2 infection. Famciclovir significantly reduced mortality, virus replication in the nervous system, and latent infection, while valaciclovir treatment resulted in virus rebound. | PMC163217 |
Cats | Naturally acquired upper respiratory tract disease | Oral | 90 mg/kg | Every 12 hours for 7-10 days | Treatment of clinical signs of feline upper respiratory disease | PMC11863213 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03120962 | Herpes Zoster ... More >> Post-herpetic Neuralgia Less << | Not Applicable | Not yet recruiting | November 2020 | - |
NCT00477334 | Genital Herpes | Phase 4 | Completed | - | - |
NCT00219310 | Recurrent Genital Herpes (RGH) | PHASE4 | COMPLETED | 2025-06-05 | Novartis Pharmaceuticals, East... More >> Hanover, New Jersey, United States Less << |
NCT00834444 | Healthy | Phase 1 | Completed | - | United States, Missouri ... More >> Gateway Medical Research, Inc. St. Charles, Missouri, United States, 63301 Canada, Ontario Ba Research Co. Toronto, Ontario, Canada, M1P2X4 Less << |
NCT00477334 | - | Completed | - | - | |
NCT00834431 | - | Completed | - | - | |
NCT00834444 | - | Completed | - | - | |
NCT00098046 | Chickenpox He... More >>rpes Zoster Less << | Phase 3 | Completed | - | United States, New York ... More >> Columbia University Medical Center New York, New York, United States, 10032 Costa Rica Novartis Investigational Site San Jose, Costa Rica Guatemala Novartis Investigational Site Cuidad de Guatemala, Guatemala Panama Novartis Investigational Site Ciudad de Panama, Panama Novartis Investigational Site David, Chiriqui, Panama Less << |
NCT00129818 | Genital Herpes | PHASE4 | COMPLETED | 2025-10-05 | University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35294, United States|Orlando Clinical Research Center, Orlando, Florida, 32809, United States|IU Center for Clinical STD Research, Indianapolis, Indiana, 46202, United States|UNC Clinical Research - Raleigh, Raleigh, North Carolina, 27607, United States|Lynne Health Science Institute, Oklahoma City, Oklahoma, 73112, United States|Westover Heights Clinic, Portland, Oregon, 97210, United States|University of Washington - Virology Research Clinic, Seattle, Washington, 98122, United States Less << |
NCT00171990 | Recurrent Genital Herpes | PHASE3 | COMPLETED | 2025-02-06 | Novartis Investigative Site, N... More >>orth Ryde, Australia Less << |
NCT01281007 | GENITAL HERPES | Phase 3 | Completed | - | Brazil ... More >> Centro de Medicina Reprodutiva Dr Carlos Isaia Filho Ltda Porto Alegre, RS, Brazil Hospital de Clínicas de Porto Alegre Porto Alegre, RS, Brazil SPVita Braganca Paulista, SP, Brazil Caep Centro Avancado de Estudos E Pesquisas Ltda Campinas, SP, Brazil CEMICAMP - Centro de Pesquisas em Saúde Reprodutiva de Campinas Campinas, SP, Brazil CECIP - Centro de Estudos Clínicos do Interior Paulista Jau, SP, Brazil Hospital das Clínicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo Ribeirao Preto, SP, Brazil, 14048900 Instituto Sirio Libanes de Ensino e Pesquisa Sao Paulo, SP, Brazil, 01308-060 Afip - Associacao Fundo de Incentivo A Psicofarmacologia Sao Paulo, SP, Brazil Less << |
NCT00834431 | Healthy | Phase 1 | Completed | - | United States, Missouri ... More >> Gateway Medical Research, Inc. St. Charles, Missouri, United States, 63301 Canada, Ontario Ba Research Co. Toronto, Ontario, Canada, M1P2X4 Less << |
NCT01281007 | - | Completed | - | - | |
NCT01327144 | Herpes Zoster | Phase 3 | Recruiting | July 2017 | Brazil ... More >> Centro de Medicina Reprodutiva Dr Carlos Isaia Filho Recruiting Porto Alegre, RS, Brazil Contact: Carlos Isaia Filho, MD 55 51 3222-8180 Principal Investigator: Carlos Isaia Filho, MD Loema Recruiting Campinas, SP, Brazil, 13010001 Contact: Fabio R Santos, MD contato@loemaipc.com.br Principal Investigator: Fabio R Santos, MD CECIP Centro de Estudos Clínicos do Interior Paulista Recruiting Jau, SP, Brazil Contact: Paula U. Tokunaga, MD cecipjau@gmail.com Principal Investigator: Paula U. Tokunaga, MD Afip - Associacao Fundo de Incentivo A Pesquisa Recruiting Sao Paulo, SP, Brazil Contact: Jane Tomimori, MD 55 11 5908 7081 Principal Investigator: Jane Tomimori, MD Allergisa Recruiting Campinas, São Paulo, Brazil Contact: Andre L Vergnanini, MD +55193789-8600 Principal Investigator: André L Vergnanini, MD Less << |
NCT00306787 | Genital Herpes | Phase 3 | Completed | - | - |
NCT01321515 | Herpes | Not Applicable | Completed | - | United States, New Jersey ... More >> Advanced Biomedical Research, Inc. Hackensack, New Jersey, United States, 07601 Less << |
NCT01321502 | Herpes | Not Applicable | Completed | - | United States, New Jersey ... More >> Advanced Biomedical Research Hackensack, New Jersey, United States, 07601 Less << |
NCT00098059 | Herpes Simplex | PHASE3 | COMPLETED | 2025-12-07 | University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35233-1711, United States|The Children's Hospital, Denver, Colorado, 80218, United States|Children's Memorial Hospital, Chicago, Illinois, 60614, United States|Kosair Charities Pediatric Clinical Research Unit, Louisville, Kentucky, 40202-3830, United States|Columbia University Medical Center, New York, New York, 10032, United States|State University of New York at, Stony Brook, New York, 11794-3362, United States|Duke University Medical Center, Durham, North Carolina, 27710, United States|Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229-3039, United States|University Hospitals of Cleveland, Cleveland, Ohio, 44106, United States|Children's Medical Center of Dallas, Dallas, Texas, 75235, United States|Baylor College of Medicine/Texas Children's Hospital, Houston, Texas, 77030, United States|Panama Minister of Health, Ciudad de David, Chiriqui, Panama|Panama Minister of Health, Ciudad de Panama, Panama Less << |
NCT00878072 | Herpes Labialis | PHASE2|PHASE3 | COMPLETED | 2010-06-02 | Women's Health Care at Frost S... More >>treet, San Diego, California, United States|Children's Memorial Hospital, Chicago, Illinois, 60614, United States|Medisphere Medical Research Center, LLC, Evansville, Indiana, 47714, United States|Clayton Medical Research, Saint Louis, Missouri, 63117, United States|Rochester Clinical Research, Inc., Rochester, New York, United States|Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, United States|University Hospitals Case Medical Center, Cleveland, Ohio, 44106, United States|Westover Heights Clinic, Portland, Oregon, 97210, United States|Primary Physicians Research, Inc, Pittsburgh, Pennsylvania, United States|Texas Children's Hospital, Houston, Texas, 77030, United States|R/D Clinical Research, Inc, Lake Jackson, Texas, 77566, United States|R/D Clinical Research, Lake Jackson, Texas, 77566, United States Less << |
NCT00448227 | Herpes Simplex | Phase 2 | Completed | - | United States, Alabama ... More >> Pediatric Infectious Disease Of University of Alabama Birmingham, Alabama, United States United States, Illinois Children's Memorial Hospital Chicago Chicago, Illinois, United States United States, Michigan Children's Hospital of Michigan Detroit, Michigan, United States United States, Nebraska Archana Chatterjee Omaha, Nebraska, United States, 68131 United States, Ohio University Hospital Cased Medical Center Rainbow Babies and Children's Hospital Cleveland, Ohio, United States United States, Texas UT Southwestern Medical Center Dallas, Texas, United States Less << |
NCT00448227 | - | Completed | - | - | |
NCT01526408 | Meniere's Disease | Phase 3 | Terminated(HRI no longer condu... More >>cting research.) Less << | - | - |
NCT00306787 | - | Completed | - | - | |
NCT01154543 | - | Completed | - | - | |
NCT00098059 | Herpes Simplex | PHASE3 | COMPLETED | 2025-12-07 | University of Alabama at Birmi... More >>ngham, Birmingham, Alabama, 35233-1711, United States|The Children's Hospital, Denver, Colorado, 80218, United States|Children's Memorial Hospital, Chicago, Illinois, 60614, United States|Kosair Charities Pediatric Clinical Research Unit, Louisville, Kentucky, 40202-3830, United States|Columbia University Medical Center, New York, New York, 10032, United States|State University of New York at, Stony Brook, New York, 11794-3362, United States|Duke University Medical Center, Durham, North Carolina, 27710, United States|Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229-3039, United States|University Hospitals of Cleveland, Cleveland, Ohio, 44106, United States|Children's Medical Center of Dallas, Dallas, Texas, 75235, United States|Baylor College of Medicine/Texas Children's Hospital, Houston, Texas, 77030, United States|Panama Minister of Health, Ciudad de David, Chiriqui, Panama|Panama Minister of Health, Ciudad de Panama, Panama Less << |
NCT00248144 | Recurrent Herpes Labialis | PHASE4 | COMPLETED | 2025-07-07 | - |
NCT05283551 | Multiple Sclerosis | PHASE2 | UNKNOWN | 2023-11-25 | Royal London Hospital, Barts H... More >>ealth NHS Trust, London, E1 1BB, United Kingdom Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.11mL 0.62mL 0.31mL |
15.56mL 3.11mL 1.56mL |
31.12mL 6.22mL 3.11mL |
Tags: Famciclovir | BRL 42810 | BRL42810 | BRL-42810 | HSV | HBV | Herpes simplex virus | Hepatitis B virus | guanine analogue | guanine analog antiviral agent | herpes simplex virus | varicella-zoster virus | penciclovir prodrug | herpes zoster | nucleoside analogue | antiviral | herpesvirus | VZV | herpesvirus | Varicella Zoster Virus | Herpesviridae | chickenpox | varicella | 104227-87-4
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H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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