Name: Ferulic acid methyl ester | Methyl ferulate; Methyl 4'-hydroxy-3'-methoxycinnamate
Brand: Ambeed
SKU: A192063
Rating: 4.5 (194 reviews)

CAS No. :	2309-07-1
Formula :	C₁₁H₁₂O₄
M.W :	208.21
SMILES Code :	O=C(OC)/C=C/C1=CC=C(O)C(OC)=C1
Synonyms :	Methyl ferulate; Methyl 4'-hydroxy-3'-methoxycinnamate
MDL No. :	MFCD00017208
InChI Key :	AUJXJFHANFIVKH-GQCTYLIASA-N
Pubchem ID :	5357283

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Bone marrow-derived macrophages (BMDMs)	50 µg/ml	18 h	CA significantly inhibited non-canonical pyroptosis, reducing LDH release and IL-1β secretion	MedComm (2020). 2023 Apr 20;4(3):e255.
RAW264.7 cells	50 µg/ml	18 h	CA significantly inhibited caspase-11 inflammasome-mediated non-canonical pyroptosis, reducing LDH release and PI uptake	MedComm (2020). 2023 Apr 20;4(3):e255.
J774A.1 macrophages	12.5-100 µg/ml	18 h	CA significantly inhibited NLRP3 inflammasome-mediated canonical pyroptosis, reducing LDH and IL-1β release	MedComm (2020). 2023 Apr 20;4(3):e255.
Caco-2 cells	0-500 μM	24 h	To evaluate the effect of ferulic acid methyl ester on cell viability, results showed no significant effect on cell survival at 500 μM concentration for 24 h.	Antioxidants (Basel). 2022 Jul 26;11(8):1448.
Human retinal endothelial cells (HRECs)	0.5mg/ml	16 h	To evaluate the effect of FA-treated microglial conditioned medium on HRECs migration and tube formation. Results showed that FA-treated microglial conditioned medium significantly inhibited HRECs migration and tube formation.	Front Immunol. 2022 Sep 2;13:976729.
BV2 murine microglial cell lines	0.5mg/ml	18 h	To evaluate the regulatory effect of FA on BV2 cell polarization under hypoxic conditions. Results showed that FA significantly reduced iNOS+ M1 microglia and increased Arg1+ M2 microglia, decreased pro-inflammatory cytokines TNF-α and IL-6 expression, and increased anti-inflammatory cytokine IL-10 expression.	Front Immunol. 2022 Sep 2;13:976729.
Primary mouse hippocampal neurons	5 and 10 μM	48 h	To evaluate the protective effect of ferulic acid methyl ester on Aβ-induced reduction of synaptic proteins. The results showed that pretreatment with ferulic acid methyl ester significantly alleviated the Aβ-induced reduction of GluN2B and p-Y1472 GluN2B, as well as PSD-95 and synapsin1.	Neurotherapeutics. 2023 Jul;20(4):1081-1108.
skeletal stem cells	30 μM	24 h	Ferulic acid significantly rescued the radiation-induced impairment of SSCs by activating the p38/MAPK and ERK/MAPK pathways, restoring their proliferation and osteogenic differentiation capabilities.	Stem Cells Transl Med. 2021 Aug;10(8):1217-1231.
Mouse tracheal epithelial cells (MTECs)	200 μM	24 h	Evaluate the effect of ferulic acid on ENaC activity, results showed that ferulic acid reversed LPS-induced reduction of ENaC activity	Respir Res. 2021 Dec 4;22(1):308.

Rats	Insomnia model	Oral	40 mg/kg	Single dose	To evaluate the effect of SMEDDS on the pharmacokinetics and tissue distribution of ferulic acid in rats. Results showed that SMEDDS significantly increased the bioavailability of ferulic acid, reduced renal distribution, and increased brain distribution.	Int J Nanomedicine. 2020 Mar 25;15:2059-2070
C57BL/6 mice	High-fat diet-induced obesity model	Dietary supplementation	50 mg/kg	Continued for 8 weeks	To evaluate the protective effect of ferulic acid methyl ester on intestinal inflammation, results showed that ferulic acid methyl ester reduced high-fat diet-induced inflammatory responses and enhanced intestinal barrier function.	Antioxidants (Basel). 2022 Jul 26;11(8):1448.
C57BL/6J mice	Oxygen-induced retinopathy (OIR) model	Intragastric administration	50 mg/kg	Twice daily from P12 to P17	To evaluate the inhibitory effect of FA on retinal neovascularization in the OIR model and its regulatory effect on microglia/macrophage polarization. Results showed that FA significantly reduced the area of retinal neovascular clusters, decreased the number of neovascular endothelial cells, and promoted reparative angiogenesis. Additionally, FA shifted microglia/macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2 phenotype and alleviated inflammatory responses.	Front Immunol. 2022 Sep 2;13:976729.
APP/PS1 transgenic mice	Alzheimer's disease model mice	Drinking water	20 mg/kg	Once daily for 30 days	Ferulic acid methyl ester counteracted ET1-mediated vasoconstriction by binding to ETRA, preventing reductions in hippocampal capillary density and diameter, and ameliorating Aβ plaque deposition and spatial memory deficits.	Neurotherapeutics. 2021 Apr;18(2):1064-1080
APP/PS1 transgenic mice	Alzheimer's disease model	Oral administration via drinking water	50 mg/kg	Once daily for 4 months	To evaluate the ameliorative effect of ferulic acid methyl ester on cognitive and behavioral deficits in APP/PS1 mice. The results showed that long-term administration of ferulic acid methyl ester significantly improved spatial learning and memory, anxiety-like behavior, and cognitive function in APP/PS1 mice.	Neurotherapeutics. 2023 Jul;20(4):1081-1108.
C57BL/J male mice	LPS-induced tracheal injury model	Intraperitoneal injection	100 mg/kg	12 hours before and 12 hours after LPS treatment	Evaluate the protective effect of ferulic acid on tracheal injury, results showed that ferulic acid improved tracheal pathological changes and up-regulated ENaC expression	Respir Res. 2021 Dec 4;22(1):308.

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	4.80mL 0.96mL 0.48mL	24.01mL 4.80mL 2.40mL	48.03mL 9.61mL 4.80mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 2309-07-1

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CAS No.: 2309-07-1

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