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Chemical Structure| 1637735-84-2 Chemical Structure| 1637735-84-2

Structure of FIIN-3
CAS No.: 1637735-84-2

Chemical Structure| 1637735-84-2

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FIIN-3 is an irreversible inhibitor of FGFR1-4 with IC50s of 13, 21, 31, and 35 nM, respectively.

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Product Details of FIIN-3

CAS No. :1637735-84-2
Formula : C34H36Cl2N8O4
M.W : 691.61
SMILES Code : C=CC(NC1=CC=C(CN(C2=NC=NC(NC3=CC=C(N4CCN(C)CC4)C=C3)=C2)C(NC5=C(Cl)C(OC)=CC(OC)=C5Cl)=O)C=C1)=O
MDL No. :MFCD28386554

Safety of FIIN-3

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of FIIN-3

RTK
JAK-STAT

Isoform Comparison

Biological Activity

Target
  • FGFR2

    FGFR2, IC50:21 nM

  • FGFR3

    FGFR3, IC50:31.4 nM

  • FGFR4

    FGFR4, IC50:35.3 nM

  • FGFR1

    FGFR1, IC50:13.1 nM

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.45mL

0.29mL

0.14mL

7.23mL

1.45mL

0.72mL

14.46mL

2.89mL

1.45mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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