Structure of Flavopiridol
CAS No.: 146426-40-6
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Flavopiridol (Alvocidib) is a broad-spectrum competitive inhibitor of CDKs, targeting CDK1, CDK2, and CDK4 with IC50 values of 30 nM, 170 nM, and 100 nM, respectively.
Synonyms: L86-8275; Alvocidib; HL 275
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CAS No. : | 146426-40-6 |
Formula : | C21H20ClNO5 |
M.W : | 401.84 |
SMILES Code : | O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@@H]4[C@H](O)CN(C)CC4 |
Synonyms : |
L86-8275; Alvocidib; HL 275
|
MDL No. : | MFCD20501884 |
InChI Key : | BIIVYFLTOXDAOV-YVEFUNNKSA-N |
Pubchem ID : | 5287969 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Target |
|
In Vitro:
Concentration | Treated Time | Description | References |
U2OS cells | 2 μM | 90-120 min | To investigate the effect of Flavopiridol on transcription elongation inhibition, results showed a dramatic increase in fluorescence recovery of RPB1, while FRAP kinetics of TAF5 and TFIIB were unaffected. | PMC5599802 |
HeLa cells | 1 μM | 30 min | Flavopiridol effectively inhibited KPNB1 transcription past the poly(A) site | PMC4424039 |
LNCaP-abl cells | 300 nM | 1 h | Flavopiridol inhibits CDK9 phosphorylation of RNA Pol II, blocking the transition of PIC to the elongation phase of transcription. PAF1 was trapped at the promoter after 1 h FP treatment and gradually traveled through the gene body upon release. | PMC8566496 |
A549 cells | 20 μM | 24 h | To evaluate the effect of Flavopiridol on the proliferation, apoptosis, clone formation, migration, and invasion ability of A549 cells. The results showed that Flavopiridol significantly inhibited the proliferation, clone formation, migration, and invasion ability of A549 cells and induced apoptosis. | PMC7242448 |
human chondrocytes | 250nM | 5 h | suppress IL-1β-induced inflammatory gene expression | PMC7785706 |
bovine cartilage explants | 60nM | 6 days | prevent IL-1β-induced cartilage degradation | PMC7785706 |
PDX282 | 0.1 µM | 24 h | To evaluate the inhibitory effect of Flavopiridol on PDX282 cells, results showed that Flavopiridol significantly inhibited cell proliferation and induced apoptosis. | PMC11185924 |
PDX303 | 0.1 µM | 24 h | To evaluate the inhibitory effect of Flavopiridol on PDX303 cells, results showed that Flavopiridol significantly inhibited cell proliferation and induced apoptosis. | PMC11185924 |
PDX214 | 0.1 µM | 24 h | To evaluate the inhibitory effect of Flavopiridol on PDX214 cells, results showed that Flavopiridol had less effect on PDX214 cells in terms of cell viability. | PMC11185924 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
BALB/c nude mice | Lung cancer xenograft model | Intraperitoneal injection | 8 mg/kg | Three times per week for 41 days | To evaluate the effect of Flavopiridol on tumor growth in the lung cancer xenograft model. The results showed that Flavopiridol significantly inhibited tumor growth, reducing tumor volume and weight. | PMC7242448 |
mice | ACL rupture model | intraperitoneal injection | 2.5mg/kg | 3 times per week for 4 weeks | reduce inflammation and osteoarthritis progression after ACL rupture | PMC7785706 |
Mice | PDX282 tumor model | Intraperitoneal injection | 5 mg/kg | 3 times per week for 11 days | To evaluate the therapeutic effect of Flavopiridol on the PDX282 tumor model, results showed that Flavopiridol significantly reduced tumor volume but also caused weight loss and unexpected death. | PMC11185924 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03604783 | Advanced Solid Tumors | Phase 1 | Not yet recruiting | May 2021 | United States, Wisconsin ... More >> Medical College of Wisconsin Not yet recruiting Milwaukee, Wisconsin, United States, 53226 Contact: Katy C Schroeder, BSN, RN, OCN 414-805-8843 Principal Investigator: Ben George, MD Less << |
NCT00055380 | Cancer | Phase 1 | Completed | - | United States, Maryland ... More >> National Institute of Dental And Craniofacial Research (NIDCR) Bethesda, Maryland, United States, 20892 Less << |
NCT00003004 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Less << |
NCT00634244 | Adult Acute Megakaryoblastic L... More >>eukemia (M7) Adult Acute Minimally Differentiated Myeloid Leukemia (M0) Adult Acute Monoblastic Leukemia (M5a) Adult Acute Monocytic Leukemia (M5b) Adult Acute Myeloblastic Leukemia With Maturation (M2) Adult Acute Myeloblastic Leukemia Without Maturation (M1) Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Adult Acute Myelomonocytic Leukemia (M4) Adult Erythroleukemia (M6a) Adult Pure Erythroid Leukemia (M6b) Recurrent Adult Acute Myeloid Leukemia Less << | Phase 2 | Completed | - | United States, Alabama ... More >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, Arizona Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, Florida Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, Illinois Northwestern University Chicago, Illinois, United States, 60611 United States, Iowa Siouxland Hematology Oncology Associates Sioux City, Iowa, United States, 51101 United States, Maryland Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center Baltimore, Maryland, United States, 21287 United States, Massachusetts Tufts Medical Center Boston, Massachusetts, United States, 02111 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Ohio The Jewish Hospital Cincinnati, Ohio, United States, 45236 United States, Pennsylvania Geisinger Medical Center Danville, Pennsylvania, United States, 17822-2001 Geisinger Medical Center-Cancer Center Hazleton Hazleton, Pennsylvania, United States, 18201 Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 Lewistown Hospital Lewistown, Pennsylvania, United States, 17044 Geisinger Medical Group State College, Pennsylvania, United States, 16801 Mount Nittany Medical Center State College, Pennsylvania, United States, 16803 Geisinger Wyoming Valley Wilkes-Barre, Pennsylvania, United States, 18711 United States, Tennessee Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Froedtert and the Medical College of Wisconsin Milwaukee, Wisconsin, United States, 53226 Israel Rambam Medical Center Haifa, Israel, 31096 Less << |
NCT00042874 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, New York ... More >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT00634244 | - | Completed | - | - | |
NCT00040729 | - | Completed | - | United States, Maryland ... More >> Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support Bethesda, Maryland, United States, 20892-1182 Less << | |
NCT00020332 | Breast Cancer | Phase 1 Phase 2 | Completed | - | United States, Maryland ... More >> Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support Bethesda, Maryland, United States, 20892-1182 Less << |
NCT00021073 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less << |
NCT02520011 | Acute Myeloid Leukemia | Phase 2 | Recruiting | December 2019 | - |
NCT00046917 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT00020189 | Head and Neck Cancer ... More >> Thromboembolism Less << | Phase 2 | Completed | - | United States, Maryland ... More >> Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support Bethesda, Maryland, United States, 20892-1182 Center for Cancer Research Bethesda, Maryland, United States, 20892 Less << |
NCT00003690 | Breast Cancer ... More >> Melanoma (Skin) Prostate Cancer Unspecified Adult Solid Tumor, Protocol Specific Less << | Phase 1 | Completed | - | United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less << |
NCT00006245 | Esophageal Cancer | Phase 2 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Less << |
NCT00795002 | Acute Myeloid Leukemia With Mu... More >>ltilineage Dysplasia Following Myelodysplastic Syndrome Adult Acute Megakaryoblastic Leukemia (M7) Adult Acute Minimally Differentiated Myeloid Leukemia (M0) Adult Acute Monoblastic Leukemia (M5a) Adult Acute Monocytic Leukemia (M5b) Adult Acute Myeloblastic Leukemia With Maturation (M2) Adult Acute Myeloblastic Leukemia Without Maturation (M1) Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Del(5q) Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Adult Acute Myelomonocytic Leukemia (M4) Adult Erythroleukemia (M6a) Adult Pure Erythroid Leukemia (M6b) Secondary Acute Myeloid Leukemia Untreated Adult Acute Myeloid Leukemia Less << | Phase 2 | Completed | - | United States, Maryland ... More >> Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Washington Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 Less << |
NCT00016185 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, Michigan ... More >> Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201-1379 Less << |
NCT00058227 | B-cell Chronic Lymphocytic Leu... More >>kemia Contiguous Stage II Grade 1 Follicular Lymphoma Contiguous Stage II Grade 2 Follicular Lymphoma Contiguous Stage II Mantle Cell Lymphoma Contiguous Stage II Marginal Zone Lymphoma Contiguous Stage II Small Lymphocytic Lymphoma Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue Nodal Marginal Zone B-cell Lymphoma Noncontiguous Stage II Grade 1 Follicular Lymphoma Noncontiguous Stage II Grade 2 Follicular Lymphoma Noncontiguous Stage II Mantle Cell Lymphoma Noncontiguous Stage II Marginal Zone Lymphoma Noncontiguous Stage II Small Lymphocytic Lymphoma Progressive Hairy Cell Leukemia, Initial Treatment Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Recurrent Small Lymphocytic Lymphoma Refractory Chronic Lymphocytic Leukemia Refractory Hairy Cell Leukemia Splenic Marginal Zone Lymphoma Stage I Chronic Lymphocytic Leukemia Stage I Grade 1 Follicular Lymphoma Stage I Grade 2 Follicular Lymphoma Stage I Mantle Cell Lymphoma Stage I Marginal Zone Lymphoma Stage I Small Lymphocytic Lymphoma Stage II Chronic Lymphocytic Leukemia Stage III Chronic Lymphocytic Leukemia Stage III Grade 1 Follicular Lymphoma Stage III Grade 2 Follicular Lymphoma Stage III Mantle Cell Lymphoma Stage III Marginal Zone Lymphoma Stage III Small Lymphocytic Lymphoma Stage IV Chronic Lymphocytic Leukemia Stage IV Grade 1 Follicular Lymphoma Stage IV Grade 2 Follicular Lymphoma Stage IV Mantle Cell Lymphoma Stage IV Marginal Zone Lymphoma Stage IV Small Lymphocytic Lymphoma Untreated Hairy Cell Leukemia Waldenstr?m Macroglobulinemia Less << | Phase 1 | Completed | - | United States, Ohio ... More >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 Less << |
NCT00006485 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Less << |
NCT00045448 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Less << |
NCT00072436 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, Massachusetts ... More >> Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT00087282 | Liver Cancer | Phase 2 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10021 Less << |
NCT00957905 | Recurrent Extragonadal Seminom... More >>a Recurrent Malignant Extragonadal Germ Cell Tumor Recurrent Malignant Extragonadal Non-Seminomatous Germ Cell Tumor Recurrent Malignant Testicular Germ Cell Tumor Recurrent Ovarian Germ Cell Tumor Stage III Testicular Cancer Stage IV Extragonadal Non-Seminomatous Germ Cell Tumor Stage IV Extragonadal Seminoma Stage IV Ovarian Germ Cell Tumor Less << | Phase 2 | Completed | - | United States, California ... More >> Tower Cancer Research Foundation Beverly Hills, California, United States, 90211-1850 City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Pennsylvania UPMC-Presbyterian Hospital Pittsburgh, Pennsylvania, United States, 15213 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 United States, Wisconsin Riverview Hospital Wisconsin Rapids, Wisconsin, United States, 54494 Less << |
NCT00957905 | - | Completed | - | - | |
NCT00064285 | Leukemia | Phase 1 | Completed | - | United States, Maryland ... More >> Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231 United States, Ohio Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University Cleveland, Ohio, United States, 44106-5047 United States, Pennsylvania Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 United States, Virginia Massey Cancer Center at Virginia Commonwealth University Richmond, Virginia, United States, 23298 Less << |
NCT01349972 | Acute Myeloid Leukemia With Mu... More >>ltilineage Dysplasia Following Myelodysplastic Syndrome Adult Acute Minimally Differentiated Myeloid Leukemia (M0) Adult Acute Monoblastic Leukemia (M5a) Adult Acute Monocytic Leukemia (M5b) Adult Acute Myeloblastic Leukemia With Maturation (M2) Adult Acute Myeloblastic Leukemia Without Maturation (M1) Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Del(5q) Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Adult Acute Myelomonocytic Leukemia (M4) Adult Erythroleukemia (M6a) Adult Pure Erythroid Leukemia (M6b) Secondary Acute Myeloid Leukemia Untreated Adult Acute Myeloid Leukemia Less << | Phase 2 | Completed | - | United States, Arizona ... More >> Mayo Clinic Scottsdale-Phoenix Scottsdale, Arizona, United States, 85259 United States, Florida Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Georgia Blood and Marrow Transplant Group of Georgia Atlanta, Georgia, United States, 30342 United States, Illinois University of Chicago Chicago, Illinois, United States, 60637 United States, Maryland University of Maryland/Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center Baltimore, Maryland, United States, 21287 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, North Carolina University of North Carolina Chapel Hill, North Carolina, United States, 27599 United States, Tennessee Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232 United States, Texas Baylor University Medical Center Dallas, Texas, United States, 75246 United States, Virginia Virginia Commonwealth University Richmond, Virginia, United States, 23298 Less << |
NCT00795002 | - | Completed | - | - | |
NCT00005074 | Lymphoma | Phase 2 | Completed | - | Canada, Nova Scotia ... More >> Nova Scotia Cancer Centre Halifax, Nova Scotia, Canada, B3H 1V7 Canada, Ontario Cancer Care Ontario-Hamilton Regional Cancer Centre Hamilton, Ontario, Canada, L8V 5C2 Toronto General Hospital Toronto, Ontario, Canada, M5G 2C4 Humber River Regional Hospital Weston, Ontario, Canada, M9N 1N8 Less << |
NCT01349972 | - | Completed | - | - | |
NCT00023894 | Endometrial Cancer | Phase 2 | Completed | - | - |
NCT03593915 | Myelodysplastic Syndromes (MDS... More >>) Less << | Phase 1 Phase 2 | Recruiting | May 2022 | United States, Maryland ... More >> Johns Hopkins Not yet recruiting Baltimore, Maryland, United States, 21218 Contact: Amy DeZern, MD Principal Investigator: Amy DeZern, MD United States, Texas US Oncology - Texas Oncology - Austin Midtown Recruiting Austin, Texas, United States, 78705 Contact: Jason Melear, MD 512-421-4163 Principal Investigator: Jason Melear, MD US Oncology - Texas Oncology - San Antonio Medical Center Recruiting San Antonio, Texas, United States, 78240 Contact: Roger Lyons, MD Principal Investigator: Roger Lyons, MD US Oncology - Texas Oncology - Tyler Recruiting Tyler, Texas, United States, 75702 Contact: Habte Yimer, MD 903-579-9800 Principal Investigator: Habte Yimer, MD United States, Washington US Oncology - Northwest Cancer Specialists, P.C. Recruiting Vancouver, Washington, United States, 98684 Contact: David A Smith, MD Principal Investigator: David A Smith, MD Less << |
NCT00094978 | Carcinoma, Small Cell ... More >> Carcinoma, Non-Small-Cell Lung Esophageal Neoplasms Mesothelioma Less << | Phase 1 | Terminated | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT00005971 | Melanoma (Skin) | Phase 2 | Completed | - | - |
NCT00016939 | Kidney Cancer | Phase 2 | Completed | - | - |
NCT00019344 | Lymphoma Pros... More >>tate Cancer Small Intestine Cancer Unspecified Adult Solid Tumor, Protocol Specific Less << | Phase 1 | Completed | - | United States, Maryland ... More >> Medicine Branch Bethesda, Maryland, United States, 20892 Less << |
NCT00407966 | Adult Acute Basophilic Leukemi... More >>a Adult Acute Eosinophilic Leukemia Adult Acute Megakaryoblastic Leukemia (M7) Adult Acute Minimally Differentiated Myeloid Leukemia (M0) Adult Acute Monoblastic Leukemia (M5a) Adult Acute Monocytic Leukemia (M5b) Adult Acute Myeloblastic Leukemia With Maturation (M2) Adult Acute Myeloblastic Leukemia Without Maturation (M1) Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Adult Acute Myelomonocytic Leukemia (M4) Adult Erythroleukemia (M6a) Adult Pure Erythroid Leukemia (M6b) Secondary Acute Myeloid Leukemia Untreated Adult Acute Myeloid Leukemia Less << | Phase 2 | Completed | - | United States, Maryland ... More >> Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 Less << |
NCT01076556 | Chronic Lymphocytic Leukemia ... More >> Prolymphocytic Leukemia Recurrent Small Lymphocytic Lymphoma Refractory Chronic Lymphocytic Leukemia Stage I Chronic Lymphocytic Leukemia Stage I Small Lymphocytic Lymphoma Stage II Chronic Lymphocytic Leukemia Stage II Small Lymphocytic Lymphoma Stage III Chronic Lymphocytic Leukemia Stage III Small Lymphocytic Lymphoma Stage IV Chronic Lymphocytic Leukemia Stage IV Small Lymphocytic Lymphoma Less << | Phase 1 | Terminated | - | United States, Ohio ... More >> Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 Less << |
NCT00470197 | Adult Acute Megakaryoblastic L... More >>eukemia (M7) Adult Acute Minimally Differentiated Myeloid Leukemia (M0) Adult Acute Monoblastic Leukemia (M5a) Adult Acute Monocytic Leukemia (M5b) Adult Acute Myeloblastic Leukemia With Maturation (M2) Adult Acute Myeloblastic Leukemia Without Maturation (M1) Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Adult Acute Myelomonocytic Leukemia (M4) Adult Erythroleukemia (M6a) Adult Pure Erythroid Leukemia (M6b) Malignant Neoplasm Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Acute Myeloid Leukemia Less << | Phase 1 | Completed | - | United States, Maryland ... More >> Johns Hopkins University Baltimore, Maryland, United States, 21287-8936 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Less << |
NCT00407966 | - | Completed | - | - | |
NCT03298984 | Acute Myeloid Leukemia | Phase 1 | Recruiting | October 2019 | United States, Maryland ... More >> Johns Hopkins Not yet recruiting Baltimore, Maryland, United States, 21287 Contact: Jackie Greer jgreer6@jhmi.edu Principal Investigator: Douglas Smith, MD United States, New York Columbia University Recruiting New York, New York, United States, 10032 Contact: Sarah Leach sl3971@cumc.columbia.edu Principal Investigator: Daniel Lee, MD United States, North Carolina University of North Carolina Recruiting Chapel Hill, North Carolina, United States, 27599 Contact: Jack Zhang jack_zhang@med.unc.edu Principal Investigator: Joshua Zeidner, MD Less << |
NCT03563560 | Acute Myeloid Leukemia | Phase 1 | Recruiting | October 31, 2019 | Japan ... More >> Chugoku Central Hospital Not yet recruiting Fukuyama, Hiroshima, Japan Contact: Chugoku Central Hospital Hokkaido University Hospital Not yet recruiting Sapporo, Hokkaido, Japan Contact: Hokkaido University Hospital University of Tsukuba Hospital Not yet recruiting Tsukuba, Ibaraki, Japan Contact: University of Tsukuba Hospital Tokai University Hospital Recruiting Isehara, Kanagawa, Japan Contact: Tokai University Hospital Osaka City Hospital Organization Not yet recruiting Miyakojima-ku, Osaka, Japan Contact: Osaka City Hospital Organization Kindai University Hospital Not yet recruiting Osakasayama, Osaka, Japan Contact: Kindai University Hospital NTT Medical Center Tokyo Not yet recruiting Shinagawa-ku, Tokyo, Japan Contact: NTT Medical Center Tokyo Kyushu University Hospital Not yet recruiting Fukuoka, Japan Contact: Kyushu University Hospital National Hospital Organization Kyushu Medical Center Not yet recruiting Fukuoka, Japan Contact: National Hospital Organization Kyushu Medical Center Fukushima Medical University Hospital Not yet recruiting Fukushima, Japan Contact: Fukushima Medical University Hospital Less << |
NCT00991952 | Adenocarcinoma of the Gastroes... More >>ophageal Junction Diffuse Adenocarcinoma of the Stomach Intestinal Adenocarcinoma of the Stomach Mixed Adenocarcinoma of the Stomach Recurrent Gastric Cancer Stage IIIA Gastric Cancer Stage IIIB Gastric Cancer Stage IIIC Gastric Cancer Stage IV Gastric Cancer Less << | Phase 2 | Completed | - | United States, California ... More >> City of Hope Duarte, California, United States, 91010 UC Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637-1470 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT00007917 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, Massachusetts ... More >> Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Less << |
NCT00991952 | - | Completed | - | - | |
NCT00082784 | Extranodal Marginal Zone Lymph... More >>oma of Mucosa-Associated Lymphoid Tissue Nodal Marginal Zone Lymphoma Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Adult Diffuse Small Cleaved Cell Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Refractory Plasma Cell Myeloma Splenic Marginal Zone Lymphoma Waldenstrom Macroglobulinemia Less << | Phase 1 | Completed | - | United States, Florida ... More >> Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Pennsylvania University of Pittsburgh Cancer Institute Pittsburgh, Pennsylvania, United States, 15232 University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15232 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 United States, Virginia Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia, United States, 23298 Less << |
NCT00070239 | Hematopoietic/Lymphoid Cancer ... More >> Unspecified Adult Solid Tumor, Protocol Specific Less << | Phase 1 | Terminated | - | United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Less << |
NCT00039455 | HER2-positive Breast Cancer ... More >> Male Breast Cancer Recurrent Breast Cancer Stage IV Breast Cancer Less << | Phase 1 | Terminated(Administratively co... More >>mplete.) Less << | - | United States, Massachusetts ... More >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Less << |
NCT00080990 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT00003256 | Prostate Cancer | Phase 2 | Completed | - | United States, California ... More >> Beckman Research Institute, City of Hope Duarte, California, United States, 91010 University of California Davis Cancer Center Sacramento, California, United States, 95817 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Wisconsin University of Wisconsin Comprehensive Cancer Center Madison, Wisconsin, United States, 53792 Less << |
NCT00016016 | Recurrent Adult Acute Lymphobl... More >>astic Leukemia Recurrent Adult Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Adult Acute Myeloid Leukemia Less << | Phase 1 Phase 2 | Completed | - | United States, Maryland ... More >> Johns Hopkins University Baltimore, Maryland, United States, 21287-8936 Less << |
NCT00098579 | Gastrointestinal Stromal Tumor... More >> Recurrent Adult Soft Tissue Sarcoma Stage IV Adult Soft Tissue Sarcoma Less << | Phase 1 | Completed | - | United States, New York ... More >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT00083122 | Recurrent Ovarian Epithelial C... More >>ancer Recurrent Primary Peritoneal Cavity Cancer Stage IIIA Ovarian Epithelial Cancer Stage IIIA Primary Peritoneal Cavity Cancer Stage IIIB Ovarian Epithelial Cancer Stage IIIB Primary Peritoneal Cavity Cancer Stage IIIC Ovarian Epithelial Cancer Stage IIIC Primary Peritoneal Cavity Cancer Stage IV Ovarian Epithelial Cancer Stage IV Primary Peritoneal Cavity Cancer Less << | Phase 2 | Completed | - | United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less << |
NCT00083122 | - | Completed | - | - | |
NCT00112684 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Terminated | - | United States, Ohio ... More >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 Less << |
NCT00012181 | Recurrent Childhood Brain Stem... More >> Glioma Recurrent Childhood Cerebellar Astrocytoma Recurrent Childhood Cerebral Astrocytoma Recurrent Childhood Ependymoma Recurrent Childhood Large Cell Lymphoma Recurrent Childhood Liver Cancer Recurrent Childhood Lymphoblastic Lymphoma Recurrent Childhood Malignant Germ Cell Tumor Recurrent Childhood Medulloblastoma Recurrent Childhood Rhabdomyosarcoma Recurrent Childhood Small Noncleaved Cell Lymphoma Recurrent Childhood Soft Tissue Sarcoma Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor Recurrent Childhood Visual Pathway and Hypothalamic Glioma Recurrent Childhood Visual Pathway Glioma Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Recurrent Neuroblastoma Recurrent Osteosarcoma Recurrent Retinoblastoma Recurrent Wilms Tumor and Other Childhood Kidney Tumors Recurrent/Refractory Childhood Hodgkin Lymphoma Unspecified Childhood Solid Tumor, Protocol Specific Less << | Phase 1 | Completed | - | United States, California ... More >> COG Phase I Consortium Arcadia, California, United States, 91006-3776 Less << |
NCT00324480 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT00005974 | Sarcoma | Phase 2 | Completed | - | - |
NCT00735930 | Anemia Chroni... More >>c Lymphocytic Leukemia Prolymphocytic Leukemia Recurrent Small Lymphocytic Lymphoma Refractory Chronic Lymphocytic Leukemia Thrombocytopenia Less << | Phase 1 | Completed | - | United States, Ohio ... More >> Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 Less << |
NCT00047307 | Adenocarcinoma of the Pancreas... More >> Recurrent Pancreatic Cancer Stage II Pancreatic Cancer Stage III Pancreatic Cancer Stage IV Pancreatic Cancer Less << | Phase 1 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT00278330 | Blastic Phase Chronic Myelogen... More >>ous Leukemia Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Acute Myeloid Leukemia Refractory Anemia With Excess Blasts Relapsing Chronic Myelogenous Leukemia Untreated Adult Acute Lymphoblastic Leukemia Untreated Adult Acute Myeloid Leukemia Less << | Phase 1 | Completed | - | United States, Virginia ... More >> Virginia Commonwealth University Richmond, Virginia, United States, 23298 Less << |
NCT00331682 | - | Completed | - | - | |
NCT00464633 | Leukemia, Lymphocytic, Chronic | Phase 2 | Completed | - | - |
NCT00047203 | Refractory Multiple Myeloma ... More >> Stage I Multiple Myeloma Stage II Multiple Myeloma Stage III Multiple Myeloma Less << | Phase 2 | Completed | - | United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less << |
NCT00003039 | Lymphoma | Phase 2 | Completed | - | United States, Illinois ... More >> Clinical Sciences Building Chicago, Illinois, United States, 60612 University of Chicago Cancer Research Center Chicago, Illinois, United States, 60637 Louis A. Weiss Memorial Hospital Chicago, Illinois, United States, 60640 Cancer Care Specialists of Central Illinois, S.C. Decatur, Illinois, United States, 62526 Evanston Northwestern Health Care Evanston, Illinois, United States, 60201 Lutheran General Hospital Park Ridge, Illinois, United States, 60068 Oncology/Hematology Associates of Central Illinois, P.C. Peoria, Illinois, United States, 61602 Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 62701 United States, Indiana Fort Wayne Medical Oncology and Hematology, Inc. Fort Wayne, Indiana, United States, 46885-5099 Michiana Hematology/Oncology P.C. South Bend, Indiana, United States, 46617 Less << |
NCT00079352 | Unspecified Adult Solid Tumor,... More >> Protocol Specific Less << | Phase 1 | Completed | - | United States, New Mexico ... More >> University of New Mexico Albuquerque, New Mexico, United States, 87106 Less << |
NCT00003620 | B-cell Chronic Lymphocytic Leu... More >>kemia Refractory Chronic Lymphocytic Leukemia Stage I Chronic Lymphocytic Leukemia Stage II Chronic Lymphocytic Leukemia Stage III Chronic Lymphocytic Leukemia Stage IV Chronic Lymphocytic Leukemia Less << | Phase 2 | Completed | - | United States, Illinois ... More >> Cancer and Leukemia Group B Chicago, Illinois, United States, 60606 Less << |
NCT00058240 | B-cell Chronic Lymphocytic Leu... More >>kemia Recurrent Small Lymphocytic Lymphoma Refractory Chronic Lymphocytic Leukemia Waldenstr?m Macroglobulinemia Less << | Phase 1 Phase 2 | Completed | - | United States, Ohio ... More >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 Less << |
NCT00331682 | Adenocarcinoma of the Pancreas... More >> Recurrent Pancreatic Cancer Stage IV Pancreatic Cancer Less << | Phase 2 | Completed | - | United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Less << |
NCT03441555 | Acute Myeloid Leukemia (AML) | Phase 1 | Recruiting | April 21, 2021 | United States, California ... More >> USC Norris Cancer Center /ID# 170844 Not yet recruiting Los Angeles, California, United States, 90033 UC Irvine /ID# 201093 Recruiting Orange, California, United States, 92868 UC Davis Comp Cancer Ctr /ID# 170799 Recruiting Sacramento, California, United States, 95817 United States, Florida Sylvester Comprehensive Cancer /ID# 170761 Recruiting Miami, Florida, United States, 33136-1002 United States, Indiana Indiana Blood & Marrow Transpl /ID# 170793 Recruiting Indianapolis, Indiana, United States, 46237 United States, New York NYU Langone Medical Center /ID# 201559 Recruiting New York, New York, United States, 10016-6402 Weill Cornell Medical College /ID# 170800 Not yet recruiting New York, New York, United States, 10021 United States, North Carolina Duke Univ Med Ctr /ID# 170842 Not yet recruiting Durham, North Carolina, United States, 27710 United States, Pennsylvania University of Pittsburgh Medic /ID# 170790 Recruiting Pittsburgh, Pennsylvania, United States, 15261 Germany Universitaetsklinikum Ulm /ID# 203649 Not yet recruiting Ulm, Thueringen, Germany, 89081 Universitaetklinikum Dresden /ID# 168636 Not yet recruiting Dresden, Germany, 01307 Univ Klinik Eppendorf Hamburg /ID# 168633 Not yet recruiting Hamburg, Germany, 20246 United Kingdom University Hospital of Wales /ID# 202302 Not yet recruiting Cardiff, United Kingdom, CF14 4EN Ninewells Hospital /ID# 202304 Recruiting Dundee, United Kingdom, DD1 9SY St. James University Hospital /ID# 202303 Not yet recruiting Leeds, United Kingdom, LS9 7TF Less << |
NCT00377104 | B-cell Chronic Lymphocytic Leu... More >>kemia Contiguous Stage II Small Lymphocytic Lymphoma Noncontiguous Stage II Small Lymphocytic Lymphoma Stage I Chronic Lymphocytic Leukemia Stage I Small Lymphocytic Lymphoma Stage II Chronic Lymphocytic Leukemia Stage III Chronic Lymphocytic Leukemia Stage III Small Lymphocytic Lymphoma Stage IV Chronic Lymphocytic Leukemia Stage IV Small Lymphocytic Lymphoma Less << | Phase 1 | Terminated | - | United States, Ohio ... More >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 Less << |
NCT00058240 | - | Completed | - | - | |
NCT00112723 | Adult Lymphocyte Depletion Hod... More >>gkin Lymphoma Adult Lymphocyte Predominant Hodgkin Lymphoma Adult Mixed Cellularity Hodgkin Lymphoma Adult Nodular Sclerosis Hodgkin Lymphoma Anaplastic Large Cell Lymphoma Angioimmunoblastic T-cell Lymphoma Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue Nodal Marginal Zone B-cell Lymphoma Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Adult Diffuse Small Cleaved Cell Lymphoma Recurrent Adult Grade III Lymphomatoid Granulomatosis Recurrent Adult Hodgkin Lymphoma Recurrent Adult T-cell Leukemia/Lymphoma Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Recurrent Mycosis Fungoides/Sezary Syndrome Recurrent Small Lymphocytic Lymphoma Refractory Multiple Myeloma Splenic Marginal Zone Lymphoma Stage I Multiple Myeloma Stage II Multiple Myeloma Stage III Multiple Myeloma Waldenstr?m Macroglobulinemia Less << | Phase 1 Phase 2 | Terminated(Administratively Co... More >>mplete) Less << | - | United States, Ohio ... More >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 Less << |
NCT00098371 | B-cell Chronic Lymphocytic Leu... More >>kemia Prolymphocytic Leukemia Refractory Chronic Lymphocytic Leukemia Less << | Phase 2 | Terminated(CTEP Initiated Acti... More >>on.) Less << | - | United States, Ohio ... More >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 Less << |
NCT00445341 | Lymphoma | PHASE1|PHASE2 | COMPLETED | 2012-10-18 | National Institutes of Health ... More >>Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States Less << |
NCT00098371 | - | Terminated(CTEP Initiated Acti... More >>on.) Less << | - | - | |
NCT00445341 | Lymphoma | PHASE1|PHASE2 | COMPLETED | 2012-10-18 | National Institutes of Health ... More >>Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, 20892, United States Less << |
NCT00101231 | Adult Acute Basophilic Leukemi... More >>a Adult Acute Eosinophilic Leukemia Adult Acute Megakaryoblastic Leukemia (M7) Adult Acute Minimally Differentiated Myeloid Leukemia (M0) Adult Acute Monoblastic Leukemia (M5a) Adult Acute Monocytic Leukemia (M5b) Adult Acute Myeloblastic Leukemia With Maturation (M2) Adult Acute Myeloblastic Leukemia Without Maturation (M1) Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Adult Acute Myelomonocytic Leukemia (M4) Adult Erythroleukemia (M6a) Adult Pure Erythroid Leukemia (M6b) Blastic Phase Chronic Myelogenous Leukemia Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Acute Myeloid Leukemia Relapsing Chronic Myelogenous Leukemia Less << | Phase 1 | Terminated | - | United States, Ohio ... More >> Ohio State University Medical Center Columbus, Ohio, United States, 43210 Less << |
NCT00112723 | - | Terminated(Administratively Co... More >>mplete) Less << | - | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
2.49mL 0.50mL 0.25mL |
12.44mL 2.49mL 1.24mL |
24.89mL 4.98mL 2.49mL |