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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 50-91-9 Chemical Structure| 50-91-9

Structure of Floxuridine
CAS No.: 50-91-9

Chemical Structure| 50-91-9

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Floxuridine is an oncology drug that belongs to antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1.

Synonyms: 5-Fluorouracil 2'-deoxyriboside; 5-FDU; FUdR. WR138720.

4.5 *For Research Use Only !

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Product Details of Floxuridine

CAS No. :50-91-9
Formula : C9H11FN2O5
M.W : 246.19
SMILES Code : OC[C@@H]1[C@H](C[C@H](N2C(NC(C(F)=C2)=O)=O)O1)O
Synonyms :
5-Fluorouracil 2'-deoxyriboside; 5-FDU; FUdR. WR138720.
MDL No. :MFCD00006530
InChI Key :ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Pubchem ID :5790

Safety of Floxuridine

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301
Precautionary Statements:P264-P270-P301+P310+P330-P405-P501
Class:6.1
UN#:2811
Packing Group:

Related Pathways of Floxuridine

DNA

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
WiDr cells 0–115.2 μM 48 hours To test the effect of terbinafine on WiDr cell proliferation, results showed that terbinafine enhanced the sensitivity to 5-FU. Cell Commun Signal. 2024 May 18;22(1):278.
RKO cells 0–115.2 μM 48 hours To test the effect of terbinafine on RKO cell proliferation, results showed that terbinafine enhanced the sensitivity to 5-FU. Cell Commun Signal. 2024 May 18;22(1):278.
Streptococcus suis SS3 0.5 µg/mL 8-12 h To evaluate the antibacterial activity of floxuridine against S. suis, results showed potent antibacterial effects in vitro Int J Mol Sci. 2023 Sep 18;24(18):14211.
Streptococcus suis ATCC 43765 0.25 µg/mL 8-12 h To evaluate the antibacterial activity of floxuridine against S. suis, results showed potent antibacterial effects in vitro Int J Mol Sci. 2023 Sep 18;24(18):14211.
mouse mammary carcinoma FM3A cells F28-7-A 1 μM 21 h induces apoptosis Int J Mol Sci. 2020 Aug 16;21(16):5876.
mouse mammary carcinoma FM3A cells F28-7 1 μM 21 h induces necrosis Int J Mol Sci. 2020 Aug 16;21(16):5876.

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
BALB/C mice Peritonitis model Intraperitoneal injection 25 and 50 mg/kg Single dose, monitored for 5 days To evaluate the therapeutic effect of floxuridine against S. suis infection, results showed significant improvement in survival rate and reduction in bacterial load Int J Mol Sci. 2023 Sep 18;24(18):14211.

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Bio Calculators
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4.06mL

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