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Chemical Structure| 531-46-4 Chemical Structure| 531-46-4

Structure of Fluoflavine
CAS No.: 531-46-4

Chemical Structure| 531-46-4

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Fluoflavine is a selective NOX1 inhibitor (IC50 = 90 nM) with over 100-fold selectivity against NOX2, NOX3, and NOX4, suitable for research related to oxidative stress and inflammation, particularly in neurodegenerative diseases and tumors.

Synonyms: ML-090; CCG-44699; NSC 179821

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Product Details of Fluoflavine

CAS No. :531-46-4
Formula : C14H10N4
M.W : 234.26
SMILES Code : C1(N2)=NC3=CC=CC=C3N=C1NC4=C2C=CC=C4
Synonyms :
ML-090; CCG-44699; NSC 179821
MDL No. :MFCD00160739

Safety of Fluoflavine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
Fluoflavine (ML-090) is a specific inhibitor of NOX1, exhibiting an IC50 value of 90 nM. It displays over 100-fold selectivity for NOX1 compared to NOX2, NOX3, and NOX4 (all IC50>10 μM). ML-090 shows an IC50 of 360 nM in HEK293 cells[1].

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