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Chemical Structure| 2226521-65-7 Chemical Structure| 2226521-65-7

Structure of FM-381
CAS No.: 2226521-65-7

Chemical Structure| 2226521-65-7

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FM381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909 at the gatekeeper position +7 in JAK3. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

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Product Details of FM-381

CAS No. :2226521-65-7
Formula : C24H24N6O2
M.W : 428.49
SMILES Code : O=C(N(C)C)C(C#N)=CC1=CC=C(C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5)O1
MDL No. :MFCD31630713
InChI Key :GJMZWYLOARVASY-NTCAYCPXSA-N
Pubchem ID :122197584

Safety of FM-381

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H332-H335
Precautionary Statements:P280-P305+P351+P338-P310

Related Pathways of FM-381

epigenetics
RTK
JAK-STAT

Isoform Comparison

Biological Activity

Target
  • JAK3

    JAK3, IC50:127 pM

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.33mL

0.47mL

0.23mL

11.67mL

2.33mL

1.17mL

23.34mL

4.67mL

2.33mL

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