Fmoc-PNA-T-OH | Pyrimidines

Peptide nucleic acid is a kind of DNA analogues that replace the main chain of sugar phosphate with polypeptide skeleton,and Fmoc-PNA-T-OH is used for PNA.

Synonyms: Fmoc-PNA-T-OH

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Quality Control of Fmoc-PNA-T-OH Purity: 95% SDS Specification

COA

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NMR

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CNMR

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Product Details of Fmoc-PNA-T-OH

CAS No. :	169396-92-3
Formula :	C₂₆H₂₆N₄O₇
M.W :	506.51
SMILES Code :	O=C(O)CN(CCNC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C(CN(C(N4)=O)C=C(C)C4=O)=O
Synonyms :	Fmoc-PNA-T-OH
MDL No. :	MFCD01940758
InChI Key :	REUYSHQBEXUIRY-UHFFFAOYSA-N
Pubchem ID :	13009309

Safety of Fmoc-PNA-T-OH

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319
Precautionary Statements:	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of Fmoc-PNA-T-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 169396-92-3 ]

[ 169396-92-3 ] Synthesis Path-Downstream 1~35

1
[ 14533-84-7 ]
[ 169396-92-3 ]
pentafluorophenyl N-<2-(N-9-fluorenylmethoxycarbonyl)aminoethyl>-N-<(thymin-1-yl)acetyl>glycinate [ No CAS ]

References: [1]Tetrahedron,1995,vol. 51,p. 6179 - 6194.

2
tert-butyl N-<2-(N-9-fluorenylmethoxycarbonyl)aminoethyl>-N-<(thymin-1-yl)acetyl>glycinate [ No CAS ]
[ 169396-92-3 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; In 1,4-dioxane;	Example 1 Synthesis of 5-methylpyrimidine-2,4,-dione PNA Monomer An Fmoc protected 5-methylpyrimidine-2,4,-dione peptide nucleic acid monomer was synthesized according to the technique described in Stephen A. Thomson, et al, Tetrahedron Vol. 51, No. 22, pp. 6179-6194, 1995, which is incorporated herein by reference in its entirety. The following synthetic scheme was conducted:

References: [1]Tetrahedron,1995,vol. 51,p. 6179 - 6194.
[2]Patent: US2007/72802,2007,A1 .Location in patent: Page/Page column 17-18.

3
[ 169396-92-3 ]
N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)lysine [ No CAS ]
C₉₄H₁₂₇N₃₅O₃₃ [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1996,vol. 6,p. 665 - 670.

4
[ 172405-62-8 ]
[ 169396-92-3 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,1996,vol. 6,p. 665 - 670.

5
[ 169396-92-3 ]
[ 681430-66-0 ]
[ 681430-80-8 ]

References: [1]Tetrahedron,2004,vol. 60,p. 2235 - 2246.

6
[ 169396-92-3 ]
[ 681430-65-9 ]
[ 681430-79-5 ]

References: [1]Tetrahedron,2004,vol. 60,p. 2235 - 2246.

7
[ 169396-92-3 ]
[ 2937-50-0 ]
[ 783371-57-3 ]

References: [1]Tetrahedron,2004,vol. 60,p. 8677 - 8690.

8
[ 140613-55-4 ]
[ 140613-56-5 ]
[ 169396-92-3 ]
[(4-amino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-amino}-acetic acid [ No CAS ]
TentaGel(R)-NHC(O)CH₂-(3-chlorophenyl-4-oxy)-P(O)O^(1-)-O-(CH₂)6NH-C(Ph)2(-C₆H₄-4-OMe) [ No CAS ]
C₇₄H₁₀₁N₂₉O₃₂P₄ [ No CAS ]

References: [1]Organic Letters,2006,vol. 8,p. 2015 - 2018.

9
[ 169396-92-3 ]
[(4-amino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-amino}-acetic acid [ No CAS ]
[(6-amino-purin-9-yl)-acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-amino}-acetic acid [ No CAS ]
[(2-amino-6-oxo-1,6-dihydro-purin-9-yl)-acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-amino}-acetic acid [ No CAS ]
TentaGel(R)-NHC(O)CH₂-(3-chlorophenyl-4-oxy)-P(O)O^(1-)-O-(CH₂)6NH-C(Ph)2(-C₆H₄-4-OMe) [ No CAS ]
C₇₇H₁₀₄N₃₅O₂₃P [ No CAS ]

References: [1]Organic Letters,2006,vol. 8,p. 2015 - 2018.

10
[ 71989-26-9 ]
[ 146982-27-6 ]
[ 169396-92-3 ]
[ 359858-14-3 ]
5⁽⁶⁾-carboxytetramethylrhodamine succinimidyl ester [ No CAS ]
2,2\::6\,,2\'\-terpyridine-4\-O(CH₂)5CO-TCACAACTA-Lys-Lys-Fl₁ (Fl₁=5⁽⁶⁾-carboxytetramethylrhodamine) [ No CAS ]