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Chemical Structure| 1429515-59-2 Chemical Structure| 1429515-59-2

Structure of FN-1501
CAS No.: 1429515-59-2

Chemical Structure| 1429515-59-2

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FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively; has anticancer activity.

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Product Details of FN-1501

CAS No. :1429515-59-2
Formula : C22H25N9O
M.W : 431.49
SMILES Code : O=C(C1=NNC=C1NC2=C3C(NC=C3)=NC=N2)NC4=CC=C(CN5CCN(C)CC5)C=C4
MDL No. :MFCD31657383

Safety of FN-1501

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of FN-1501

RTK
Hedgehog

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03690154 Advanced Cancer|Solid Tumors|A... More >>cute Myeloid Leukemia Refractory|Acute Myeloid Leukemia, in Relapse Less << PHASE1 TERMINATED 2022-02-11 KUMC Cancer Center, Fairway, K... More >>ansas, 66205, United States|Karmanos Cancer Institute, Detroit, Michigan, 48334, United States|Cabrini Malvern Hospital, Malvern, Victoria, 3144, Australia Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.32mL

0.46mL

0.23mL

11.59mL

2.32mL

1.16mL

23.18mL

4.64mL

2.32mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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