Structure of Foscarnet sodium
CAS No.: 63585-09-1
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Foscarnet sodium can inhibit dNTPs thus attenuats viral RNA polymerases, reverse transcriptase, and DNA polymerases. It is used in the treatment of cytomegalovirus retinitis.
Synonyms: Phosphonoformic acid trisodium salt; Trisodium phosphonoformate; Phosphonoformate
4.5
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| CAS No. : | 63585-09-1 |
| Formula : | CNa3O5P |
| M.W : | 191.95 |
| SMILES Code : | O=C(P([O-])([O-])=O)[O-].[Na+].[Na+].[Na+] |
| Synonyms : |
Phosphonoformic acid trisodium salt; Trisodium phosphonoformate; Phosphonoformate
|
| MDL No. : | MFCD00013973 |
| InChI Key : | DFHAXXVZCFXGOQ-UHFFFAOYSA-K |
| Pubchem ID : | 44561 |
| GHS Pictogram: |
|
| Signal Word: | Warning |
| Hazard Statements: | H302-H315-H319-H335 |
| Precautionary Statements: | P261-P305+P351+P338 |
In Vitro:
|
Cell Line
|
Concentration | Treated Time | Description | References |
| Klebsiella pneumoniae Kp142 | 0.623 mM | 24 hours | Evaluate the synergistic effect of PPF with fosfomycin, showing that PPF at 0.623 mM concentration has a synergistic effect with fosfomycin. | Antimicrob Agents Chemother. 2021 Feb 17;65(3):e01911-20 |
| Klebsiella pneumoniae Kp12 | 0.623 mM | 24 hours | Evaluate the synergistic effect of PPF with fosfomycin, showing that PPF at 0.623 mM concentration has a synergistic effect with fosfomycin. | Antimicrob Agents Chemother. 2021 Feb 17;65(3):e01911-20 |
| Klebsiella pneumoniae ATCC 700721 | 0.623 mM | 24 hours | Evaluate the synergistic effect of PPF with fosfomycin, showing that PPF at 0.623 mM concentration has a synergistic effect with fosfomycin. | Antimicrob Agents Chemother. 2021 Feb 17;65(3):e01911-20 |
| RPE-1 cells | 200 µM | 72 hours | To evaluate the inhibitory effect of foscarnet on HCMV gene expression, results showed that foscarnet dampened mCherry-SCP expression and the second phase of mNeonGreen-ie1/2 | Front Cell Infect Microbiol. 2021 Jan 8;10:536150 |
| MRC-5 cells | 200 µM | 72 hours | To evaluate the inhibitory effect of foscarnet on HCMV gene expression, results showed that foscarnet dampened mCherry-SCP expression and the second phase of mNeonGreen-ie1/2 | Front Cell Infect Microbiol. 2021 Jan 8;10:536150 |
| MRC-5 cells | 0 to 400 μM (WT), 0 to 100 μM (hypersusceptible viruses) | 6 days | Evaluate the susceptibility of recombinant HCMV viruses to foscarnet sodium, showing hypersusceptibility of Q579I and K805Q mutant viruses (EC50 0.12- and 0.19-fold that of WT, respectively) | Antimicrob Agents Chemother. 2020 Mar 24;64(4):e01910-19 |
Clinical Trial:
| NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
| NCT00000729 | HIV Infections | PHASE1 | COMPLETED | 1992-06-01 | Los Angeles County - USC Med C... More >>tr, Los Angeles, California, 90033, United States|USC School of Medicine / Norris Cancer Hosp, Los Angeles, California, 90033, United States|Univ of California / San Diego Treatment Ctr, San Diego, California, 921036325, United States|Univ of Minnesota, Minneapolis, Minnesota, 55455, United States|City Hosp Ctr at Elmhurst / Mount Sinai Hosp, Elmhurst, New York, 11373, United States|Mem Sloan - Kettering Cancer Ctr, New York, New York, 10021, United States|Mount Sinai Med Ctr, New York, New York, 10029, United States|SUNY - Stony Brook, Stony Brook, New York, 117948153, United States|Ohio State Univ Hosp Clinic, Columbus, Ohio, 432101228, United States|Julio Arroyo, West Columbia, South Carolina, 29169, United States|Univ of Washington, Seattle, Washington, 98105, United States Less << |
| NCT00000726 | Cytomegalovirus Retinitis|HIV ... More >>Infections Less << | PHASE1 | COMPLETED | 1992-02-01 | Los Angeles County - USC Med C... More >>tr, Los Angeles, California, 90033, United States|USC School of Medicine / Norris Cancer Hosp, Los Angeles, California, 90033, United States|UCLA CARE Ctr, Los Angeles, California, 90095, United States|San Francisco AIDS Clinic / San Francisco Gen Hosp, San Francisco, California, 941102859, United States|Mem Sloan - Kettering Cancer Ctr, New York, New York, 10021, United States Less << |
| NCT00002145 | HIV Infections|Gastrointestina... More >>l Diseases Less << | PHASE3 | COMPLETED | - | East Bay AIDS Ctr, Berkeley, C... More >>alifornia, 94705, United States|Los Angeles County - USC Med Ctr, Los Angeles, California, 90033, United States|UCSD, San Diego, California, 92103, United States|UCSF - San Francisco Gen Hosp, San Francisco, California, 94110, United States|Miami Veterans Administration Med Ctr, Miami, Florida, 33125, United States|Emory Univ School of Medicine, Atlanta, Georgia, 30303, United States|Rush Presbyterian - Saint Luke's Med Ctr, Chicago, Illinois, 60612, United States|Dr Robert Bresalier / Henry Ford Hosp, Detroit, Michigan, 48202, United States|Dr Douglas Dieterich, New York, New York, 10016, United States|Dept of Veterans Affairs, Northport, New York, 11768, United States|Ohio State Univ Hosp, Columbus, Ohio, 43210, United States|Comprehensive Care Ctr, Dallas, Texas, 75235, United States|Univ TX Galveston Med Branch, Galveston, Texas, 77555, United States|Houston Veterans Administration Med Ctr, Houston, Texas, 77030, United States|Med College of Virginia, Richmond, Virginia, 232980711, United States Less << |
| NCT00002144 | Herpes Simplex|HIV Infections | PHASE1 | COMPLETED | - | CARE Ctr / UCLA Med Ctr, Los A... More >>ngeles, California, 90095, United States|George Washington Univ Med Ctr, Washington, District of Columbia, 20037, United States|South Miami Hosp, Miami, Florida, 33143, United States|Dr Thomas Klein, Chicago, Illinois, 60610, United States|Bellevue Hosp Ctr, New York, New York, 10016, United States|Univ Hosps of Cleveland, Cleveland, Ohio, 44106, United States|Roger Williams Med Ctr, Providence, Rhode Island, 02908, United States|Milwaukee County Med Complex, Milwaukee, Wisconsin, 53226, United States Less << |
| NCT00002039 | Cytomegalovirus Retinitis|HIV ... More >>Infections Less << | COMPLETED | - | Foscarnet Research Program / P... More >>ark Plaza Hosp, Houston, Texas, 77004, United States Less << | |
| NCT00002432 | Cytomegalovirus Retinitis|HIV ... More >>Infections Less << | COMPLETED | - | Davies Med Ctr, San Francisco,... More >> California, 94114, United States Less << | |
| NCT00002125 | Cytomegalovirus Retinitis|HIV ... More >>Infections Less << | PHASE4 | COMPLETED | - | Dr Ralph Hansen, Beverly Hills... More >>, California, 90210, United States|Dr Milan Fiala, Los Angeles, California, 900246970, United States|Dr G Michael Wool, Los Angeles, California, 90067, United States|AIDS Community Research Consortium, Redwood City, California, 94063, United States|Ingenix Kern McNeill Decatur, Atlanta, Georgia, 30309, United States|Dr John Karedes, Indianapolis, Indiana, 46204, United States|Dr Paul Benson, Berkley, Michigan, 48072, United States|Dr Ronald Nahass, Somerville, New Jersey, 08876, United States|Dr Ronald J Grossman, New York, New York, 10016, United States|Community Health Network, Rochester, New York, 14620, United States|Austin Infectious Disease Consultants, Austin, Texas, 78705, United States Less << |
| NCT00002301 | Cytomegalovirus Retinitis|HIV ... More >>Infections Less << | UNKNOWN | - | Foscarnet Research Program / P... More >>ark Plaza Hosp, Houston, Texas, 77004, United States Less << | |
| NCT00000697 | Cytomegalovirus Retinitis|HIV ... More >>Infections Less << | PHASE2 | WITHDRAWN | - | - |
| NCT00002272 | Herpes Simplex|HIV Infections | COMPLETED | - | Foscarnet Research Program / P... More >>ark Plaza Hosp, Houston, Texas, 77004, United States Less << | |
| NCT00000691 | Cytomegalovirus Retinitis|HIV ... More >>Infections Less << | PHASE2 | COMPLETED | 1992-08-01 | USC CRS, Los Angeles, Californ... More >>ia, 90033, United States|Ucsf Aids Crs, San Francisco, California, 94114, United States|Univ. of Miami AIDS CRS, Miami, Florida, 33136, United States|Johns Hopkins Adult AIDS CRS, Baltimore, Maryland, 21287, United States|Massachusetts General Hospital ACTG CRS, Boston, Massachusetts, 02114, United States|Washington U CRS, Saint Louis, Missouri, United States|SUNY - Buffalo, Erie County Medical Ctr., Buffalo, New York, 14215, United States|NY Univ. HIV/AIDS CRS, New York, New York, 10016, United States|Cornell University A2201, New York, New York, 10021, United States|Univ. of Rochester ACTG CRS, Rochester, New York, 14642, United States|Duke Univ. Med. Ctr. Adult CRS, Durham, North Carolina, 27710, United States Less << |
| NCT00002021 | Herpes Simplex|HIV Infections | COMPLETED | - | UCLA CARE Ctr, Los Angeles, Ca... More >>lifornia, 90095, United States|Huntington Memorial Hosp, Pasadena, California, 91105, United States Less << |
| Bio Calculators | ||||
| Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
|
1 mM 5 mM 10 mM |
5.21mL 1.04mL 0.52mL |
26.05mL 5.21mL 2.60mL |
52.10mL 10.42mL 5.21mL |
|
Tags: Foscarnet | Trisodium phosphonoformate | Phosphonoformic acid trisodium | DNA/RNA Synthesis | viral | DNA polymerase | reversible | suppression | replication | antiherpesvirus | cytomegalovirus | retinitis | 63585-09-1 |
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| P378 | |
| P380 | Evacuate area. |
| P381 | Eliminate all ignition sources if safe to do so. |
| P390 | Absorb spillage to prevent material damage. |
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| P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
| P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
| P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
| P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
| P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
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