Structure of Fremanezumab
CAS No.: 1655501-53-3
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Fremanezumab is a humanized IgG2 monoclonal antibody that prevents CGRP from binding to its receptor by binding to CGRP. Fremanezumab has potential for research in migraine prevention.
Synonyms: TEV-48125
4.5
*For Research Use Only !
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Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 1655501-53-3 |
M.W : | 146 kDa |
SMILES Code : | NONE |
Synonyms : |
TEV-48125
|
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319 |
Precautionary Statements: | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03539393 | Migraine | AVAILABLE | - | - | |
NCT06659120 | Menstrual Migraine | RECRUITING | 2027-03-31 | Department of Neurology, Insel... More >>spital, Bern, 3010, Switzerland Less << | |
NCT03107052 | Cluster Headache | PHASE3 | TERMINATED | 2019-06-11 | Teva Investigational Site 1383... More >>4, Phoenix, Arizona, 85018, United States|Teva Investigational Site 13819, Canoga Park, California, 91303, United States|Teva Investigational Site 13811, Santa Monica, California, 90404, United States|Teva Investigational Site 13823, Stanford, California, 94305, United States|Teva Investigational Site 13837, Aurora, Colorado, 80045, United States|Teva Investigational Site 13814, Colorado Springs, Colorado, 80918, United States|Teva Investigational Site 13836, Denver, Colorado, 80218, United States|Teva Investigational Site 13813, Englewood, Colorado, 80113, United States|Teva Investigational Site 13821, New Haven, Connecticut, 06510-2483, United States|Teva Investigational Site 13812, Stamford, Connecticut, 06905, United States|Teva Investigational Site 13810, Gainesville, Florida, 32607, United States|Teva Investigational Site 13815, Orlando, Florida, 32806, United States|Teva Investigational Site 13829, Ormond Beach, Florida, 32174, United States|Teva Investigational Site 13830, Saint Petersburg, Florida, 33709, United States|Teva Investigational Site 13842, Tampa, Florida, 33612, United States|Teva Investigational Site 13840, Tampa, Florida, 33634, United States|Teva Investigational Site 13833, Columbus, Georgia, 31904, United States|Teva Investigational Site 13826, Chicago, Illinois, 60614, United States|Teva Investigational Site 13818, Ann Arbor, Michigan, 48104, United States|Teva Investigational Site 13835, Las Vegas, Nevada, 89106, United States|Teva Investigational Site 13832, Las Vegas, Nevada, 89113, United States|Teva Investigational Site 13831, Lebanon, New Hampshire, 03756, United States|Teva Investigational Site 13820, Princeton, New Jersey, 08540, United States|Teva Investigational Site 13827, Albuquerque, New Mexico, 87102, United States|Teva Investigational Site 13816, Amherst, New York, 14226, United States|Teva Investigational Site 13817, New York, New York, 10019, United States|Teva Investigational Site 13809, Raleigh, North Carolina, 27607, United States|Teva Investigational Site 13839, Salisbury, North Carolina, 28144, United States|Teva Investigational Site 13825, Cleveland, Ohio, 44195, United States|Teva Investigational Site 13824, Philadelphia, Pennsylvania, 19107, United States|Teva Investigational Site 13841, Richmond, Texas, 77307, United States|Teva Investigational Site 13822, Virginia Beach, Virginia, 23454, United States|Teva Investigational Site 78120, Auchenflower, 4066, Australia|Teva Investigational Site 78118, Clayton, 3168, Australia|Teva Investigational Site 78123, Melbourne, 3004, Australia|Teva Investigational Site 78122, Parkville, 3050, Australia|Teva Investigational Site 78121, Randwick, 2031, Australia|Teva Investigational Site 11132, Newmarket, Ontario, L3Y5G8, Canada|Teva Investigational Site 11130, Calgary, Canada|Teva Investigational Site 40030, Helsinki, 00180, Finland|Teva Investigational Site 40031, Oulu, 90100, Finland|Teva Investigational Site 40029, Turku, 20100, Finland|Teva Investigational Site 32666, Berlin, 10117, Germany|Teva Investigational Site 32667, Bochum, 44787, Germany|Teva Investigational Site 32660, Essen, 45147, Germany|Teva Investigational Site 32665, Hamburg, 20246, Germany|Teva Investigational Site 32662, Kiel, 24149, Germany|Teva Investigational Site 32661, Konigstein im Taunus, 61462, Germany|Teva Investigational Site 32663, Rostock, 18147, Germany|Teva Investigational Site 80124, Ashkelon, 7830604, Israel|Teva Investigational Site 80122, Hadera, 3810101, Israel|Teva Investigational Site 80125, Holon, 58100, Israel|Teva Investigational Site 80121, Jerusalem, 9112001, Israel|Teva Investigational Site 80123, Netanya, 4244916, Israel|Teva Investigational Site 80120, Ramat Gan, 5265601, Israel|Teva Investigational Site 80127, Tel Aviv, 64239, Israel|Teva Investigational Site 80126, Tel-Aviv, 6812509, Israel|Teva Investigational Site 30190, Milan, 20133, Italy|Teva Investigational Site 30192, Modena, 41124, Italy|Teva Investigational Site 30194, Napoli, 80131, Italy|Teva Investigational Site 30193, Pavia, 27100, Italy|Teva Investigational Site 30191, Rome, 00161, Italy|Teva Investigational Site 30189, Rome, 00163, Italy|Teva Investigational Site 38118, Leiden, 2333 ZA, Netherlands|Teva Investigational Site 38119, Nijmegen, 6532 SZ, Netherlands|Teva Investigational Site 38117, Zwolle, 8025 AB, Netherlands|Teva Investigational Site 53380, Bialystok, 15-402, Poland|Teva Investigational Site 53383, Krakow, 31-505, Poland|Teva Investigational Site 53379, Krakow, 33-332, Poland|Teva Investigational Site 53382, Lodz, 90-338, Poland|Teva Investigational Site 53381, Szczecin, 70-111, Poland|Teva Investigational Site 31211, Galdakao., 48960, Spain|Teva Investigational Site 31214, Madrid, 28034, Spain|Teva Investigational Site 31213, Sevilla, 41013, Spain|Teva Investigational Site 31212, Valladolid, 47003, Spain|Teva Investigational Site 31215, Zaragoza, 50009, Spain|Teva Investigational Site 42047, Huddinge, 141 86, Sweden|Teva Investigational Site 42045, Vallingby, 162 68, Sweden|Teva Investigational Site 34224, Glasgow, G51 4TF, United Kingdom|Teva Investigational Site 34222, Liverpool, L9 7LJ, United Kingdom|Teva Investigational Site 34223, London, SE1 9RT, United Kingdom|Teva Investigational Site 34220, London, W6 8RF, United Kingdom|Teva Investigational Site 34221, Oxford, OX3 9DU, United Kingdom Less << |
NCT04530110 | Migraine | PHASE3 | ACTIVE_NOT_RECRUITING | 2026-03-21 | Teva Investigational Site 1431... More >>9, Aurora, Colorado, 80045, United States|Teva Investigational Site 14368, Colorado Springs, Colorado, 80907, United States|Teva Investigational Site 14244, Jacksonville, Florida, 32256, United States|Teva Investigational Site 14325, Miami, Florida, 33155, United States|Teva Investigational Site 14250, West Palm Beach, Florida, 33407, United States|Teva Investigational Site 14255, West Palm Beach, Florida, 33409, United States|Teva Investigational Site 14243, Atlanta, Georgia, 30328, United States|Teva Investigational Site 14258, Savannah, Georgia, 31406, United States|Teva Investigational Site 14263, Hoffman Estates, Illinois, 60169, United States|Teva Investigational Site 14245, Wichita, Kansas, 67206, United States|Teva Investigational Site 14327, Louisville, Kentucky, 40202, United States|Teva Investigational Site 14360, Covington, Louisiana, 70433, United States|Teva Investigational Site 14365, Baltimore, Maryland, 21201, United States|Teva Investigational Site 14246, Waltham, Massachusetts, 02451, United States|Teva Investigational Site 14251, Ann Arbor, Michigan, 48104, United States|Teva Investigational Site 14270, Minneapolis, Minnesota, 55402, United States|Teva Investigational Site 14376, Ridgeland, Mississippi, 39157, United States|Teva Investigational Site 14256, Bridgeton, Missouri, 63044-2513, United States|Teva Investigational Site 14371, New Brunswick, New Jersey, 08901, United States|Teva Investigational Site 14276, Amherst, New York, 14226, United States|Teva Investigational Site 14377, Durham, North Carolina, 27710, United States|Teva Investigational Site 14248, Raleigh, North Carolina, 27607, United States|Teva Investigational Site 14264, Cincinnati, Ohio, 45229-3039, United States|Teva Investigational Site 14257, Oklahoma City, Oklahoma, 73112, United States|Teva Investigational Site 14363, Tulsa, Oklahoma, 74136, United States|Teva Investigational Site 14364, Philadelphia, Pennsylvania, 19104-4318, United States|Teva Investigational Site 14374, Bristol, Tennessee, 37620, United States|Teva Investigational Site 14252, Austin, Texas, 78731, United States|Teva Investigational Site 14273, Austin, Texas, 78759, United States|Teva Investigational Site 14367, Dallas, Texas, 75235-7701, United States|Teva Investigational Site 14375, Salt Lake City, Utah, 84109, United States|Teva Investigational Site 14323, Norfolk, Virginia, 23510, United States|Teva Investigational Site 11182, Ottawa, Ontario, K1H 8L1, Canada|Teva Investigational Site 11179, Ottawa, Ontario, K2G 1W2, Canada|Teva Investigational Site 11181, Montreal, Quebec, H4A 3J1, Canada|Teva Investigational Site 40053, Helsinki, 00380, Finland|Teva Investigational Site 40049, Kuopio, 70210, Finland|Teva Investigational Site 40054, Oulu, 90100, Finland|Teva Investigational Site 40052, Tampere, 33521, Finland|Teva Investigational Site 32728, Bad Homburg, 61350, Germany|Teva Investigational Site 32729, Berlin, 13353, Germany|Teva Investigational Site 32726, Leipzig, 04177, Germany|Teva Investigational Site 80170, Be'er Ya'akov, 7033001, Israel|Teva Investigational Site 80166, Haifa, 3104802, Israel|Teva Investigational Site 80168, Holon, 58100, Israel|Teva Investigational Site 80169, Jerusalem, 9124001, Israel|Teva Investigational Site 80167, Ramat Gan, 5265601, Israel|Teva Investigational Site 80164, Safed, 1311001, Israel|Teva Investigational Site 80165, Tel-Aviv, 6423906, Israel|Teva Investigational Site 30230, Firenze, 50139, Italy|Teva Investigational Site 30239, Milano, 20132, Italy|Teva Investigational Site 30228, Milano, 20133, Italy|Teva Investigational Site 30226, Milano, 20148, Italy|Teva Investigational Site 30238, Padua, 35128, Italy|Teva Investigational Site 30227, Pavia, 27100, Italy|Teva Investigational Site 30225, Rome, 00163, Italy|Teva Investigational Site 38138, Doetinchem, 7009 BL, Netherlands|Teva Investigational Site 38135, Nijmegen, 6532 SZ, Netherlands|Teva Investigational Site 38136, Rotterdam, 3015 GD, Netherlands|Teva Investigational Site 53441, Gdansk, 80-389, Poland|Teva Investigational Site 53437, Kielce, 25-316, Poland|Teva Investigational Site 53443, Krakow, 30-363, Poland|Teva Investigational Site 53452, Krakow, 30-539, Poland|Teva Investigational Site 53440, Lublin, 20-582, Poland|Teva Investigational Site 53439, Poznan, 60-355, Poland|Teva Investigational Site 53451, Poznan, 61-731, Poland|Teva Investigational Site 53442, Szczecin, 70-111, Poland|Teva Investigational Site 31271, Barcelona, 08035, Spain|Teva Investigational Site 31270, Valencia, 46026, Spain|Teva Investigational Site 31265, Valladolid, 47010, Spain Less << |
Tags: Fremanezumab | TEV-48125 | CGRP Receptor | CGRP Receptor/monoclonal antibody | Neuronal Signaling | GPCR/G Protein | Human Inhibitory Monoclonal Antibody | 1655501-53-3
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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