Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

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CAS No. :	1953-04-4
Formula :	C₁₇H₂₂BrNO₃
M.W :	368.27
SMILES Code :	O[C@H]1C=C[C@@]23CCN(C)CC4=CC=C(OC)C(O[C@@]3([H])C1)=C24.Br
Synonyms :	Galantamine hydrobromide; Galanthamine hydrobromide; NSC 100058
MDL No. :	MFCD00067672
InChI Key :	QORVDGQLPPAFRS-XPSHAMGMSA-N
Pubchem ID :	121587

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301
Precautionary Statements:	P301+P310
Class:	6.1
UN#:	1544
Packing Group:	Ⅲ

HT-22 cells	10 μM	24 hours	To investigate the effect of galantamine on Mi-sup-induced inflammatory response in HT-22 cells. Galantamine reduced the Mi-sup-induced increase in NF-κB p65 levels and expression of pro-inflammatory cytokines (IL-1β and IL-6).	J Neuroinflammation. 2018 Apr 18;15(1):112
BV-2 cells	10 μM	24 hours	To investigate the effect of galantamine on LPS-induced inflammatory response in BV-2 cells. Galantamine reduced the LPS-induced increase in NF-κB p65 levels.	J Neuroinflammation. 2018 Apr 18;15(1):112
α7 nACh receptors stably expressed in HEK293 cells	10 nM to 10 μM	40 s pre-application (60 s for 0.01 μM), followed by 250 ms co-application with ACh	To validate modulatory effects of galanthamine on α7 nACh receptors in HEK293 cells. Results aligned with oocyte experiments, showing no positive modulation and inhibition at high concentrations (100 μM).	Br J Pharmacol. 2018 Jul;175(14):2911-2925
RAW 264.7 cells	10 μmol/L	24 hours	To investigate the effect of Galanthamine on LPS-induced migration of RAW 264.7 cells, results showed that Galanthamine significantly inhibited LPS-induced cell migration.	Acta Pharm Sin B. 2020 Oct;10(10):1926-1942

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CAS No.: 1953-04-4

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CAS No.: 1953-04-4

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Kunming mice	LPS-induced neuroinflammation model	Intraperitoneal injection	4 mg/kg	Once daily for 14 days	To investigate the effect of galantamine on LPS-induced cognitive impairment and neuroinflammation. Galantamine improved LPS-induced deficits in spatial learning and memory, reduced the expression of CD11b, GFAP, NF-κB p65, and pro-inflammatory cytokines in the hippocampus, and increased the levels of synapse-associated proteins (SYN and PSD-95).	J Neuroinflammation. 2018 Apr 18;15(1):112
Wistar rats	Adolescent intermittent ethanol (AIE) exposure model	Intraperitoneal injection	4 mg/kg	In the prevention study, administered 30 min prior to each gavage, totaling 16 doses; in the restoration study, administered daily for 2 weeks starting from P57	Galanthamine prevented and reversed AIE-induced neuroimmune signaling and loss of hippocampal neurogenesis. In the prevention study, galantamine pretreatment blocked AIE induction of CCL2, HMGB1, and COX-2, and prevented the reduction in neurogenesis. In the restoration study, galantamine treatment reversed AIE induction of these inflammatory markers and restored neurogenesis.	J Neuroinflammation. 2021 Sep 16;18(1):212
Mice	Caerulein-induced acute pancreatitis model	Intraperitoneal injection	1, 4, or 6 mg/kg body weight	Administered once 1 hour before the first caerulein injection and again 30 minutes after the third injection	Galanthamine significantly attenuated pancreatic histologic injury, reflected by a reduction in serum amylase and pancreatic inflammatory cytokines and an increase in the anti-inflammatory cytokine IL-10 in the serum. These beneficial effects were not altered by bilateral subdiaphragmatic vagotomy, knockout of either choline acetyltransferase-positive T cells or α7nAChR, or administration of the nAChR ganglionic blocker mecamylamine or the more selective α7nAChR antagonist methyllycaconitine.	Mol Med. 2023 Oct 31;29(1):149
Mice	Opa1–/– mice and aged WT mice	Oral	3.28 mg/kg bodyweight/d	Daily for 90 days (Opa1–/– mice) or 18 weeks (aged mice)	RJx-01 (containing Galanthamine) improved muscle function, reduced denervation, decreased inflammatory markers, ameliorated mitochondrial morphology and autophagy, and increased satellite cell content.	JCI Insight. 2023 Aug 8;8(15):e168787
Mice	FMF-KI mice (MefvV726A/V726A)	Intraperitoneal injection	4-12 mg/kg (escalated by 4 mg every 2 weeks)	Twice daily for 8 weeks	To assess the impact of long-term Galanthamine on chronic inflammation in FMF-KI mice. Results demonstrated significant attenuation of splenomegaly, reduced inflammatory cell infiltration (e.g., spleen and subcutaneous air pouch), decreased serum amyloid A (SAA) levels, and improved anemia. Notably, Galanthamine's effects persisted in vagotomized or α7nAChR-KO mice, suggesting a mechanism independent of the classical cholinergic anti-inflammatory pathway.	Mol Med. 2022 Dec 9;28(1):148
Sprague-Dawley rats	Cardiac ischemia/reperfusion (I/R) model	Isolated heart perfusion	5 × 10^-8 M	30 min ischemia followed by 40 min reperfusion	To investigate the effect of galantamine on cardiac ischemia/reperfusion injury in isolated hearts. Results showed that galantamine treatment significantly improved left ventricular function (LVDP, ±dP/dt, WP) without affecting heart rate.	Mol Med. 2017 Jul;23:120-133
Male adult Wistar rats	Experimental model of dementia induced by scopolamine	Intraperitoneal injection	1 mg/kg	For 9 consecutive days	To evaluate the neuroprotective effects of galantamine in scopolamine-induced dementia in rats. Results showed that galantamine significantly increased brain ACh levels, improved recognition memory and habituation, and restored the cholinergic system influence index.	Antioxidants (Basel). 2022 Feb 12;11(2):374
NOD mice	Type 1 diabetes model	Intraperitoneal injection	1 mg/kg	Daily for 20 weeks	To study the preventive effects of galantamine in type 1 diabetes, results showed that galantamine significantly delayed the onset of hyperglycemia, reduced pancreatic islet inflammation, and decreased serum levels of anti-insulin antibodies.	Mol Med. 2015 Nov;21(1):702-708

NCT00236574	Dementia\|Alzheimer Disease	PHASE3	COMPLETED	2025-11-03	-
NCT00297362	Alzheimer Disease		COMPLETED	2025-10-05	-
NCT00338117	Alzheimer's Disease\|Dementia	PHASE3	COMPLETED	1997-05-01	-
NCT00236431	Dementia\|Alzheimer Disease	PHASE3	COMPLETED	2025-12-03	-

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	2.72mL 0.54mL 0.27mL	13.58mL 2.72mL 1.36mL	27.15mL 5.43mL 2.72mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2 The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed