CAS No. :	62499-27-8
Formula :	C₁₃H₁₈O₇
M.W :	286.28
SMILES Code :	OCC1=CC=C(C=C1)O[C@@H]2O[C@H](CO)[C@H]([C@@H]([C@H]2O)O)O
Synonyms :	Gastrodine
MDL No. :	MFCD00272169
InChI Key :	PUQSUZTXKPLAPR-UJPOAAIJSA-N
Pubchem ID :	115067

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P280-P305+P351+P338

SCC25-CR cells	20 µM	12 hours	Inhibited glycolysis and HK2 expression	Cell Death Discov. 2023 Oct 2;9(1):364.
Neonatal rat cardiomyocytes (NRCMs)	100 µM	12 hours	Gastrodin alleviated phenylephrine-induced cardiomyocyte hypertrophy, as indicated by reduced cell surface area and decreased ANF and cTnT protein expression	Front Pharmacol. 2017 Apr 25;8:222.
SCC4-CR cells	10, 20, 40 µM	24 hours	Inhibited glycolysis and HK2 expression, promoted apoptosis	Cell Death Discov. 2023 Oct 2;9(1):364.
CAL27-CR cells	10, 20, 40 µM	24 hours	Inhibited glycolysis and HK2 expression, promoted apoptosis	Cell Death Discov. 2023 Oct 2;9(1):364.
HepG2 cells	10, 30, 100 µM	24 hours	Gastrodin alleviated insulin resistance by increasing glucose consumption, glucose uptake, and glycogen content in dexamethasone-induced HepG2 cells. The Western blotting results showed that gastrodin upregulated the expression of insulin receptors and ubiquitin-specific protease 4 (USP4) and increased the phosphorylation of GATA binding protein 1 (GATA1) and protein kinase B (AKT) in vivo and in vitro.	Front Pharmacol. 2021 Sep 16;12:710722.
Rat kidney fibroblast cell lines (NRK-49F)	25-100 µM	24 hours	To evaluate the effect of gastrodin on the expression of α-SMA, fibronectin, collagen I, and p-Smad2/p-Smad3 proteins in TGF-β1-stimulated NRK-49F cells. Results showed gastrodin significantly reversed their upregulation without affecting cell viability.	Front Pharmacol. 2023 Jan 17;14:1082281.
PC12 cells	0.1–100 µM	24–48 hours	Evaluate the effect of Gastrodin on the survival rate of PC12 cells, results showed that 0.1–100 µM Gastrodin had no significant effect on the survival rate of Q23 and Q74 PC12 cells after 24–48 h of incubation	Int J Mol Sci. 2024 Jul 14;25(14):7709.
Q74 PC12 cells	1, 5, 25 µM	36 hours	Gastrodin significantly reduces the expression levels of mHtt and polyQ proteins in a dose-dependent manner	Int J Mol Sci. 2024 Jul 14;25(14):7709.
Q74 PC12 cells	25 µM	36 hours	Gastrodin promotes neurite outgrowth in Q74 PC12 cells and improves cell morphology	Int J Mol Sci. 2024 Jul 14;25(14):7709.
H9c2 cardiomyocytes	20, 50, 100 µM	4 hours	GAS pretreatment significantly ameliorated the decrease in cell viability and increase in apoptosis of H9c2 cells treated with 400 μM H2O2 for 3 h.	Acta Pharmacol Sin. 2020 Oct;41(10):1314-1327.
Neonatal rat cardiac fibroblasts (CFs)	1 µM or 5 µM	48 hours	To evaluate the inhibitory effect of gastrodin on high glucose and high palmitic acid (HG-PA)-induced differentiation, collagen synthesis, and cell migration in cardiac fibroblasts. Results showed that gastrodin significantly inhibited the increase in α-SMA protein and mRNA levels, as well as the expression of collagen I and collagen III induced by HG-PA.	Chin Med. 2024 Nov 22;19(1):164.
Macrophages	10 µM or 100 µM	6 hours or 12 hours	To evaluate the inhibitory effect of Gastrodin on VSV and HSV-1 infection. Results showed that Gastrodin significantly reduced the viral load of VSV and HSV-1 in macrophages.	Front Pharmacol. 2021 Feb 19;11:608707.
Human umbilical vein endothelial cells (HUVECs)	50 µM and 100 µM	6 hours pretreatment followed by 24 hours	To evaluate the effect of Gastrodin on H2O2-induced senescence in HUVECs. Results showed that Gastrodin reduced the proportion of SA β-gal positive cells, decreased the expression levels of p16 and p21 proteins, and enhanced the proliferation and migration ability of HUVECs.	J Cell Mol Med. 2024 Feb;28(3):e18089.

C57BL/6J mice	Chronic unpredictable mouse stress (CUMS) model	Intragastric administration	10 mg/kg and 20 mg/kg	Once daily for 28 consecutive days	Gastrodin improved depression-like behaviors and nerve cell injury in CUMS mice by inhibiting Caspase-3-mediated apoptosis	CNS Neurosci Ther. 2024 Mar;30(3):e14444
C57BL/6J mice	VSV or HSV-1 infection model	Intraperitoneal injection	10 mg/kg or 100 mg/kg	Single dose, observed for 96 hours	To evaluate the protective effect of Gastrodin on VSV and HSV-1 infected mice. Results showed that Gastrodin significantly improved the survival rate of infected mice and reduced viral load.	Front Pharmacol. 2021 Feb 19;11:608707.
Nude mice	CAL27-CR xenograft model	Intraperitoneal injection	10 mg/kg, 30 mg/kg	Every two days until the end of the experiment	Inhibited tumor growth and glycolysis	Cell Death Discov. 2023 Oct 2;9(1):364.
B6-hHTT130-N transgenic mice	Huntington's disease model	Oral	100 mg/kg	Once daily until 12 weeks of age	Gastrodin increases grip strength and attenuates mHtt aggregates in B6-hHTT130-N transgenic mice	Int J Mol Sci. 2024 Jul 14;25(14):7709.
Sprague-Dawley rats	Subarachnoid hemorrhage model	Intraperitoneal injection	100 mg/kg/ day	Administered at 2, 24, and 48 hours after SAH	Gastrodin significantly attenuated SAH-induced neurological deficits, brain edema, and increased blood-brain barrier permeability, while reducing glutamate concentration in cerebrospinal fluid and intracellular Ca2+ overload, suppressing microglial and astrocyte activation, and neuronal apoptosis.	Neurosci Bull. 2019 Jun;35(3):461-470
C57BL/6 mice	DSS-induced colitis model	Oral gavage	20 mg/kg/day	Once daily for two weeks	Gastrodin alleviates DSS-induced colitis by strengthening intestinal barrier and modulating gut microbiota	Foods. 2024 Aug 3;13(15):2460
ICR mice	D-galactose-induced Alzheimer's disease model	Oral gavage	3 mg/kg, 90 mg/kg, 210 mg/kg	Daily for 9 weeks	Gastrodin improved memory dysfunction in D-galactose-induced AD mice by regulating gut microbiota composition and inhibiting neuronal inflammation.	Front Pharmacol. 2022 Jun 2;13:814271
Spontaneously hypertensive rats (SHRs)	Hypertensive renal injury model	Intragastric administration	3.5 mg/kg/day	Once daily for 10 weeks	To investigate the protective effects of gastrodin against hypertensive renal injury and fibrosis. Results demonstrated gastrodin attenuated renal injury, reduced collagen deposition, and downregulated TGF-β1/Smad2/3 signaling pathway proteins.	Front Pharmacol. 2023 Jan 17;14:1082281.
Wistar rats	Type 2 diabetes model	Oral gavage	30, 60, 90 mg/kg	Once daily for 6 weeks	After 6 weeks of treatment with gastrodin, fasting blood glucose levels, blood lipid metabolism, and insulin sensitivity index values were remarkably reduced. Gastrodin also alleviated liver toxicity caused by diabetes and relieved pathological damage to the pancreas in T2DM rats.	Front Pharmacol. 2021 Sep 16;12:710722.
Mice	3xTg-AD mouse model	Intragastric	50 mg/kg and 100 mg/kg	Once daily for 30 days	Gastrodin alleviates tau pathology by targeting FERMT2, reversing the reduction in brain viscoelasticity, and improving cognitive function and spatial recognition abilities.	CNS Neurosci Ther. 2025 Mar;31(3):e70283
C57BL/6 mice	Pentylenetetrazole (PTZ)-induced seizure model	Intraperitoneal injection	50 mg/kg, 100 mg/kg, 200 mg/kg	Single administration	Gastrodin attenuates PTZ-induced seizures by modulating MAPK-associated inflammatory responses, improving EEG patterns, reducing levels of pro-inflammatory cytokines IL-1β and TNF-α, increasing levels of anti-inflammatory cytokine IL-10, and inhibiting microglial activation.	Neurosci Bull. 2017 Jun;33(3):264-272
C57 mice	Phenylephrine or angiotensin II-induced cardiac hypertrophy model	Intraperitoneal injection	50 mg/kg/day	Once daily for 3 weeks	Gastrodin alleviated phenylephrine or angiotensin II-induced cardiac hypertrophy, as indicated by reduced heart size, decreased heart weight/body weight ratio, and reduced ANF and cTnT protein expression	Front Pharmacol. 2017 Apr 25;8:222.
C57BL/6 mice	Diabetic cardiomyopathy (DCM) model	Gavage	50 mg/kg/day (low dose) or 100 mg/kg/day (high dose)	Once every two days for 12 weeks	To evaluate the effect of gastrodin on cardiac function and myocardial fibrosis in diabetic cardiomyopathy mice. Results showed that gastrodin significantly improved cardiac function, reduced myocardial fibrosis, and decreased the expression of KLK8 and PAR1.	Chin Med. 2024 Nov 22;19(1):164.
C57BL/6J mice	LPS-induced neuroinflammation and depressive-like behavior model	Intraperitoneal injection	50, 100, 200 mg/kg	Single administration, behavioral tests performed at 6 and 24 hours post-administration	Gastrodin ameliorates LPS-induced neuroinflammation and depressive-like behaviors by downregulating miR-107-3p	Front Pharmacol. 2022 Dec 8;13:1044375

NCT03221894	-		Recruiting	September 2017	China ... More >> Dongzhimen Hospital Recruiting Beijing, China Contact: Jing Shi, M.D. 86-10-84013132 shijing87@hotmail.com Less <<
NCT00297245	Cognitive Decline	Phase 4	Unknown	-	China, Hubei ... More >> Department of Anesthesiology, Union Hospital Recruiting Wuhan, Hubei, China, 430022 Contact: Shihai Zhang, M.D., Ph.D. 862-785-726-834 zhangshh@public.wh.hb.cn Principal Investigator: Shihai Zhang, M.D., Ph.D. Less <<
NCT02156024	Masked Hypertension	Phase 4	Unknown	-	China, Shanghai ... More >> Ruijin Hospital Recruiting Shanghai, Shanghai, China, 200025 Contact: Yan Li, doctor 021-64370045 ext 663228 liyanshcn@yahoo.com Principal Investigator: Yan Li, docter Less <<

{[proInfo.proName]}

CAS No.: 62499-27-8

{[proInfo.proName]}

CAS No.: 62499-27-8

Alternative Products

Product Details of Gastrodin

Safety of Gastrodin

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	3.49mL 0.70mL 0.35mL	17.47mL 3.49mL 1.75mL	34.93mL 6.99mL 3.49mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2 The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed