Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

CAS No. :	6902-77-8
Formula :	C₁₁H₁₄O₅
M.W :	226.23
SMILES Code :	O=C(C1=CO[C@@H](O)[C@@]2([H])[C@]1([H])CC=C2CO)OC
Synonyms :	(+)-Genipin
MDL No. :	MFCD00888600
InChI Key :	AZKVWQKMDGGDSV-BCMRRPTOSA-N
Pubchem ID :	442424

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301
Precautionary Statements:	P301+P310+P330
Class:	6.1
UN#:	2811
Packing Group:	Ⅲ

SCC-9 cells	10, 30, 60 µM	72 hours	Inhibited cell growth and induced apoptosis	Drug Des Devel Ther. 2020 Jan 29;14:395-405.
SCC-25 cells	10, 30, 60 µM	72 hours	Inhibited cell growth and induced apoptosis	Drug Des Devel Ther. 2020 Jan 29;14:395-405.
GLUTag L-cells	0.1 µM, 1 µM, 10 µM, 100 µM	1 hour	To evaluate the effect of Genipin on GLP-1 secretion, results showed Genipin significantly stimulated GLP-1 secretion	Int J Mol Sci. 2023 Jan 21;24(3):2131.
RAW264.7 cells	1, 10, 50, 100 µM	24 hours	To evaluate the effect of Genipin on inflammatory responses in Pam3CSK4 or LPS-stimulated RAW264.7 cells. Genipin significantly suppressed Pam3CSK4 or LPS-induced production of nitrites, TNF-α, IL-1β, IL-6, and HMGB1.	Mol Med. 2012 May 9;18(1):455-65.
ARPE-19 cells	30 µM	24 hours	To investigate the protective effects of Genipin on H2O2-induced oxidative damage in ARPE-19 cells. Results showed that Genipin reversed the inhibitory effects of H2O2 by promoting cell viability, attenuating ROS accumulation and cell apoptosis, and increased the expression of Nrf2, HO-1, and NQO1.	Int J Mol Med. 2019 Feb;43(2):936-944.
Mouse mesenchymal stromal cells	0, 0.01, 0.05, 0.1, 0.5, 1, or 10 mM	24 hours	Evaluate differentiation potential, results showed that cells on 10 mM Genipin-mixed collagen gels differentiated into vascular smooth muscle cells, while cells on 0 mM Genipin-mixed collagen gels differentiated into visceral smooth muscle cells.	Gels. 2023 Feb 10;9(2):148.
H1299 human lung cancer cells	0, 0.01, 0.05, 0.1, 0.5, 1, or 10 mM	24 hours	Evaluate cell morphology changes, results showed that cells on 10 mM Genipin-mixed collagen gels exhibited spreading morphology, while cells on 0 mM Genipin-mixed collagen gels maintained a round shape.	Gels. 2023 Feb 10;9(2):148.
Mouse Leydig tumor MLTC-1 cells	20 µM	24 hours	To assess the effect of genipin on steroidogenesis, results showed that genipin significantly increased progesterone secretion and upregulated mRNA and protein expression of StAR and CYP11A1 in MLTC-1 cells	Reprod Biol Endocrinol. 2020 Dec 11;18(1):122.
HMC3 cells	5 µM, 10 µM, 20 µM	4 hours pretreatment followed by 12 hours stimulation	To evaluate the inhibitory effect of Genipin on inflammation and lipid accumulation in LPS/HG/PA-induced HMC3 cells. Results showed that Genipin significantly reduced the expressions of M1 phenotype biomarkers (TNF-α, IL-6, iNOS mRNA, CCL2 mRNA) and increased the expressions of M2 phenotype biomarkers (IL-4, IL-10, ARG1 mRNA, YM1 mRNA), inhibited CD68 expression and increased CD206 expression.	Antioxidants (Basel). 2022 Dec 29;12(1):74.
AML-12 cells	40 µM	48 hours	Genipin suppressed CCL2/CCR2 axis via PPARγ-mediated p65 degradation.	Int J Biol Sci. 2023 Oct 16;19(16):5257-5274.
Bone marrow-derived mononuclear cells (BMDMs)	80 µM	48 hours	Genipin promoted phagocytosis and differentiation of BMDMs.	Int J Biol Sci. 2023 Oct 16;19(16):5257-5274.
NHOK cells	0 to 400 µM	48 hours	No significant effect at concentrations below 100 μM	Drug Des Devel Ther. 2020 Jan 29;14:395-405.
Yeast cells	10 µM	6 hours	Genipin reduced αSyn-GFP aggregation and toxicity, decreasing cell death and inclusion formation.	Nat Commun. 2023 Apr 6;14(1):1918.
Human retinal microvascular endothelial cells (hRMECs)	0.4 µM	7 days	Genipin promoted cell viability in high glucose-induced hRMECs, reduced apoptosis, inhibited the increase in ATP, ROS, MMP, and 2-NBDG levels, and decreased the expression of inflammatory cytokines TNF-α, IL-1β, IL-18, and NLRP3.	World J Diabetes. 2023 Sep 15;14(9):1349-1368.
M2 macrophages	150 µM/ml	72 hours	To evaluate the effect of Genipin on the polarization of M2 macrophages, results showed that Genipin maintained and enhanced the expression of arginase 1 and Ym-1 in M2 macrophages.	Acta Biomater. 2021 Sep 1;131:198-210.
M1 macrophages	150 µM/ml	72 hours	To evaluate the effect of Genipin on the polarization of M1 macrophages, results showed that Genipin reduced the expression of iNOS and IL-1β in M1 macrophages.	Acta Biomater. 2021 Sep 1;131:198-210.
M0 macrophages	150 µM/ml	72 hours	To evaluate the effect of Genipin on the polarization of M0 macrophages, results showed that Genipin induced M0 macrophages to polarize towards the M2 subtype, as evidenced by increased expression of arginase 1 and Ym-1.	Acta Biomater. 2021 Sep 1;131:198-210.

Mice	Corneal stromal injury model	Topical application	0.1% , 0.125 % or 0.25% for 2 mins or 0.5% for 5 mins	Single application	To evaluate the effects of genipin on corneal stromal healing, higher concentrations of genipin were found to result in denser stromal scarring	Ocul Surf. 2023 Apr;28:115-123
Drosophila melanogaster	PD model overexpressing αSyn-GFP	Food feeding	1 mM	Food changed every 2 days, observing lifespan and motor performance	Genipin significantly increased lifespan and motor performance in flies, reducing insoluble αSyn-GFP aggregates.	Nat Commun. 2023 Apr 6;14(1):1918.
ICR mice	Cecal ligation and puncture (CLP)-induced sepsis model and LPS-induced endotoxemia model	Intravenous injection (CLP model) and intraperitoneal injection (LPS model)	1, 2.5, 5 mg/kg	Single or double administration (24-hour interval), observed for 10 days	To evaluate the protective effect of Genipin on sepsis and endotoxemia. Genipin significantly improved the survival rate of septic mice induced by CLP and LPS, attenuated multiple organ dysfunction, inhibited the activation of TLR2 and TLR4 signaling pathways, and reduced the release of proinflammatory cytokines and HMGB1.	Mol Med. 2012 May 9;18(1):455-65.
Mice	Sepsis model induced by caecal ligation and puncture (CLP)	Intravenous injection	1, 2.5, 5 mg/kg	Single dose, observation up to 10 days	Genipin protects against septic liver injury by restoring impaired autophagic flux, improving survival rate, and reducing serum aminotransferases and pro-inflammatory cytokine levels.	Br J Pharmacol. 2016 Mar;173(6):980-91
ICR mice	STZ/HFD-induced diabetic cognitive impairment model	Intragastric administration and brain stereotaxic injection	10 mg/kg, 20 mg/kg, 40 mg/kg	Intragastric administration four times a week for 4 weeks; brain stereotaxic injection once at the 7th and 9th weeks	To evaluate the ameliorative effect of Genipin on diabetic cognitive impairment. Results showed that Genipin reduced blood glucose levels, improved glucose and insulin tolerance in OGTT and ITT, increased the discrimination index in novel object recognition, decreased escape latency, increased platform crossing times and time in target quadrant in Morris water maze, and reduced error number in passive avoidance test.	Antioxidants (Basel). 2022 Dec 29;12(1):74.
C57/BL6 mice	Streptozotocin (STZ)-induced diabetic mice model	Intraocular injection	10 mM	After 3 months of STZ administration, body weight and fasting blood glucose were assessed every 2 weeks for 1 month.	Genipin via intraocular injection reduced ROS levels and glucose uptake in the retina of STZ mice, decreased the expression of inflammatory cytokines and pathway proteins, maintained retinal structure, and reduced oxidative stress and inflammation levels.	World J Diabetes. 2023 Sep 15;14(9):1349-1368.
ICR mice	Circadian disruption model	Oral gavage	25 mg/kg	Once daily for 5 or 10 weeks	To evaluate the ameliorative effect of genipin on reproductive health problems caused by circadian disruption, results showed that genipin treatment restored testis size and morphology, improved sperm concentration and motility, and normalized serum levels of testosterone, dihydrotestosterone, and androstenedione	Reprod Biol Endocrinol. 2020 Dec 11;18(1):122.
C57BL/6 mice	Orthotopic HCC recurrence model	Oral	25 mg/kg and 50 mg/kg	Every other day until the end of the experiment	Genipin significantly delayed postoperative HCC recurrence by inhibiting macrophage infiltration and CCL2/CCR2 axis.	Int J Biol Sci. 2023 Oct 16;19(16):5257-5274.
BALB/c nude mice	OSCC xenograft model	Intraperitoneal injection	30 mg/kg	One week	Significantly reduced tumor size and weight	Drug Des Devel Ther. 2020 Jan 29;14:395-405.
Mice	High-fat-diet-induced obese mouse model	Oral gavage	50 mg/kg/day	Once daily for 6 weeks	To evaluate the effect of Genipin on blood glucose and insulin resistance, results showed Genipin improved hyperglycemia and insulin resistance	Int J Mol Sci. 2023 Jan 21;24(3):2131.

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CAS No.: 6902-77-8

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CAS No.: 6902-77-8

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Precautionary Statements-General

Prevention

Response

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	4.42mL 0.88mL 0.44mL	22.10mL 4.42mL 2.21mL	44.20mL 8.84mL 4.42mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2 The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed