Home Cart Sign in  
Chemical Structure| 27741-01-1 Chemical Structure| 27741-01-1

Structure of Geniposidic acid
CAS No.: 27741-01-1

Chemical Structure| 27741-01-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

Geniposidic Acid is a naturally occuring iridoid glucoside HSF1 inducer, with anti-inflammatory and anti-cancer agent.

Synonyms: Geniposidic Acid

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of Geniposidic acid

CAS No. :27741-01-1
Formula : C16H22O10
M.W : 374.34
SMILES Code : O=C(C1=CO[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)[C@@]3([H])[C@]1([H])CC=C3CO)O
Synonyms :
Geniposidic Acid
MDL No. :MFCD00210294
InChI Key :ZJDOESGVOWAULF-OGJQONSISA-N
Pubchem ID :443354

Safety of Geniposidic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
K6001 yeast 1 µM Significantly prolonged the replicative lifespan of yeast Antioxidants (Basel). 2021 Jun 21;10(6):987
Mouse bone marrow mononuclear cells (BMMCs) 100 or 1000 µg/mL 48 hours GPA suppressed sRANKL and M-CSF-induced osteoclast differentiation of BMMCs (56.7% suppression) and inhibited mRNA expression of OSCAR, NFATc1, c-Fos, cathepsin K, and DC-STAMP. Biomedicines. 2022 Dec 1;10(12):3096
Human gingival epithelial cells (HGECs) 100 µg/mL 12 hours GPA suppressed P. gingivalis-induced IL-6 mRNA expression (33.8% suppression) and IL-6 protein production (69.2% suppression), and inhibited TLR2 expression and MAPK phosphorylation. Biomedicines. 2022 Dec 1;10(12):3096
bone marrow-derived monocytes (BMDM)-differentiated macrophages 25-100 μM 24 hours GPA pretreatment significantly inhibited the mRNA levels of NLRP3, NFκB1 and IL-1β Redox Biol. 2022 Sep;55:102404
THP-1 monocyte-derived macrophages 25-100 μM 24 hours GPA pretreatment significantly inhibited the mRNA levels of NLRP3, NFκB1 and IL-1β Redox Biol. 2022 Sep;55:102404
mouse chondrocytes 12.5, 25, 50 μM 24 hours GPA markedly inhibited IL-1β-induced inflammatory mediator and MMPs production and NF-κB activation. J Cell Mol Med. 2024 Apr;28(8):e18228
BY4741 yeast 1 µM 24 hours Improved the survival rate of yeast under oxidative stress and reduced the levels of ROS and MDA Antioxidants (Basel). 2021 Jun 21;10(6):987
mouse chondrocytes 12.5, 25, 50 μM 24 hours GPA significantly inhibited IL-1β-induced inflammatory mediators and MMPs production, and inhibited IL-1β-induced ferroptosis. J Cell Mol Med. 2024 Apr;28(8):e18228

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
BALB/c mice OVA-induced asthma model Intraperitoneal injection 12.5, 25, 50 mg/kg Once daily for the last three days GPA protects mice against OVA-induced asthma by suppressing inflammation and regulating gut microbiota. Front Immunol. 2025 Feb 25;16:1549459
C57BL/6J Jcl mice P. gingivalis-induced periodontitis model Oral inoculation 50 mg/50 µL Twice per week for six weeks GPA inhibited P. gingivalis-induced alveolar bone resorption (25.6% suppression) and reduced IL-6 and TLR2 levels in serum and gingiva. Biomedicines. 2022 Dec 1;10(12):3096
C57 mice Destabilization of the medial meniscus (DMM) model Intraperitoneal injection 50 mg/kg GPA could alleviate DMM-induced OA in mice, significantly increase the thickness of cartilage and reduce the number of fibrocartilage. J Cell Mol Med. 2024 Apr;28(8):e18228
C57BL/6 mice ANIT-induced cholestatic liver injury Oral 100, 50, 25 mg/kg Once daily for seven days GPA pretreatment effectively improved ANIT-induced cholestatic liver injury as evidenced by decreased liver weight index, serum levels of biochemical parameters, including ALT, AST, TBA, and TBIL Redox Biol. 2022 Sep;55:102404

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.36mL

2.67mL

1.34mL

26.71mL

5.34mL

2.67mL

References

 

Historical Records

Categories