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Chemical Structure| 60976-49-0 Chemical Structure| 60976-49-0

Structure of Geraniin
CAS No.: 60976-49-0

Chemical Structure| 60976-49-0

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Geraniin is a naturally occuring dehydroellagitannin found in geraniums which can mediates apoptosis.

Synonyms: NSC 359346

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Product Details of Geraniin

CAS No. :60976-49-0
Formula : C41H28O27
M.W : 952.64
SMILES Code : OC1(O)C2C3=C(OC1(O)C(C=C2C(O[C@H]4[C@@H]([C@H](O5)[C@@H](O[C@@H]4COC(C6=C(C7=C8C=C(C(O)=C7O)O)C(O)=C(C(O)=C6)O)=O)OC(C9=CC(O)=C(C(O)=C9)O)=O)OC8=O)=O)=O)C(O)=C(O)C=C3C5=O
Synonyms :
NSC 359346
MDL No. :MFCD09038731

Safety of Geraniin

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.05mL

0.21mL

0.10mL

5.25mL

1.05mL

0.52mL

10.50mL

2.10mL

1.05mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

[1]Wang P, Peng X, et al. Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway. Biochim Biophys Acta. 2015 Sep;1850(9):1751-61.

[2]Xiao F, Zhai Z, et al. Geraniin suppresses RANKL-induced osteoclastogenesis in vitro and ameliorates wear particle-induced osteolysis in mouse model. Exp Cell Res. 2015 Jan 1;330(1):91-101.

[3]Jiang L, Liu Y, He P, Chen J, Liu S, Tan N. Geraniin ameliorates cisplatin-induced nephrotoxicity in mice. Free Radic Res. 2016 Aug;50(8):813-9

[4]Lu C, Gao S, Xu G. Geraniin inhibits TNF-α-induced impairments of osteogenesis through NF-κB and p38 MAPK signalling pathways in bone marrow stem cells. Stroke Vasc Neurol. 2017 Apr 21;2(2):47-52

[5]Wang D, Dong X, Wang B, Liu Y, Li S. Geraniin Attenuates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Inhibiting Toll-Like Receptor 4 Activation. J Agric Food Chem. 2019 Sep 11;67(36):10079-10088

[6]Zhu G, Xin X, Liu Y, Huang Y, Li K, Wu C. Geraniin attenuates LPS-induced acute lung injury via inhibiting NF-κB and activating Nrf2 signaling pathways. Oncotarget. 2017 Apr 4;8(14):22835-22841

[7]Liu X, Li J, Peng X, Lv B, Wang P, Zhao X, Yu B. Geraniin Inhibits LPS-Induced THP-1 Macrophages Switching to M1 Phenotype via SOCS1/NF-κB Pathway. Inflammation. 2016 Aug;39(4):1421-33

[8]Chung APYS, Gurtu S, Chakravarthi S, Moorthy M, Palanisamy UD. Geraniin Protects High-Fat Diet-Induced Oxidative Stress in Sprague Dawley Rats. Front Nutr. 2018 Mar 16;5:17

 

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