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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
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Inaccessible (Haz class 6.1), International USD 150+
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Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 39262-14-1 Chemical Structure| 39262-14-1

Structure of Ginsenoside C-K
CAS No.: 39262-14-1

Chemical Structure| 39262-14-1

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Ginsenoside C-K (Standard) is the analytical standard of Ginsenoside C-K. This product is used for research and analytical applications. Ginsenoside C-K is a bacterial metabolite of Ginsenoside Rb1. Ginsenoside C-K exerts anti-inflammatory effects by inhibiting inducible nitric oxide synthase (iNOS) and COX-2. In human liver microsomes, Ginsenoside C-K inhibits the activities of CYP2C9 and CYP2A6 with IC50 values of 32.0±3.6 μM and 63.6±4.2 μM, respectively.

Synonyms: Ginsenoside compound K; Ginsenoside K; Ginsenoside IH901

4.5 *For Research Use Only !

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Product Details of Ginsenoside C-K

CAS No. :39262-14-1
Formula : C36H62O8
M.W : 622.87
SMILES Code : C[C@@]([C@@]12C)(CC[C@@]3([H])C4(C)C)[C@@](C[C@@H](O)[C@]1([H])[C@]([C@@](CC/C=C(C)/C)(C)O[C@@H]([C@@H]([C@@H](O)[C@@H]5O)O)O[C@@H]5CO)([H])CC2)([H])[C@]3(CC[C@@H]4O)C
Synonyms :
Ginsenoside compound K; Ginsenoside K; Ginsenoside IH901
MDL No. :MFCD07772261
InChI Key :FVIZARNDLVOMSU-IRFFNABBSA-N
Pubchem ID :9852086

Safety of Ginsenoside C-K

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301+H311+H331
Precautionary Statements:P501-P261-P270-P271-P264-P280-P361+P364-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.61mL

0.32mL

0.16mL

8.03mL

1.61mL

0.80mL

16.05mL

3.21mL

1.61mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

[1]Yang XD, Yang YY, et al. A review of biotransformation and pharmacology of ginsenoside compound K. Fitoterapia. 2015 Jan;100:208-20.

[2]Mathiyalagan R, Subramaniyam S, et al. Ginsenoside compound K-bearing glycol chitosan conjugates: synthesis, physicochemical characterization, and in vitro biological studies. Carbohydr Polym. 2014 Nov 4;112:359-66.

[3]Sun M, Zhuang X, Lv G, Lin Z, Huang X, Zhao J, Lin H, Wang Y. Ginsenoside CK Inhibits TGF-β-Induced Epithelial-Mesenchymal Transition in A549 Cell via SIRT1. Biomed Res Int. 2021 Dec 12;2021:9140191

[4]Chen K, Jiao J, Xue J, Chen T, Hou Y, Jiang Y, Qian L, Wang Y, Ma Z, Liang Z, Sun B, Ren Q. Ginsenoside CK induces apoptosis and suppresses proliferation and invasion of human osteosarcoma cells through the PI3K/mTOR/p70S6K1 pathway. Oncol Rep. 2020 Mar;43(3):886-896

[5]Zhang J, Ma X, Fan D. Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma. Foods. 2021 May 26;10(6):1195

[6]Li X, Huang Q, Wang M, Yan X, Song X, Ma R, Jiang R, Zhao D, Sun L. Compound K Inhibits Autophagy-Mediated Apoptosis Through Activation of the PI3K-Akt Signaling Pathway Thus Protecting Against Ischemia/Reperfusion Injury. Cell Physiol Biochem. 2018;47(6):2589-2601

[7]Law CK, Kwok HH, Poon PY, Lau CC, Jiang ZH, Tai WC, Hsiao WW, Mak NK, Yue PY, Wong RN. Ginsenoside compound K induces apoptosis in nasopharyngeal carcinoma cells via activation of apoptosis-inducing factor. Chin Med. 2014 Apr 2;9(1):11

 

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