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Chemical Structure| 41753-43-9 Chemical Structure| 41753-43-9

Structure of Ginsenoside Rb1
CAS No.: 41753-43-9

Chemical Structure| 41753-43-9

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Ginsenoside Rb1, a natural product isolated and purified from the roots of Panax ginseng C. A. Mey. with anti-oxidative damage ,anti-renal interstitial fibrosis, immunostimulatory and anticancer effects, promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway.

Synonyms: Gypenoside III; NSC 310103

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Product Details of Ginsenoside Rb1

CAS No. :41753-43-9
Formula : C54H92O23
M.W : 1109.29
SMILES Code : C[C@@]([C@@](CC1)(C)[C@@]2([H])[C@@]1([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)(CC5)[C@@](C[C@H]2O)([H])[C@]6(C)[C@]5([H])C(C)(C)[C@@H](O[C@H](O[C@@H]7CO)[C@@H]([C@@H](O)[C@@H]7O)O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)CC6
Synonyms :
Gypenoside III; NSC 310103
MDL No. :MFCD00133367

Safety of Ginsenoside Rb1

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302+H312+H332
Precautionary Statements:P280

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
M146L cells 5, 10, 20 µg/mL 12 hours To evaluate the effect of ginsenoside Rh1 on the viability of M146L cells. The results showed that ginsenoside Rh1 had a very significant difference in cell activity at 5 µg/mL (p < 0.01), a significant difference at 10 µg/mL (p < 0.05), and no significant difference at 20 µg/mL. Nutrients. 2023 Nov 22;15(23):4878

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

0.90mL

0.18mL

0.09mL

4.51mL

0.90mL

0.45mL

9.01mL

1.80mL

0.90mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

[1]Zhang XJ, He C, et al. Ginsenoside Rb1 attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of the JNK and p38 signaling pathways. Vascul Pharmacol. 2015 Oct;73:86-95.

[2]Chen T, Xiao L, et al. Anti-Asthmatic Effects of Ginsenoside Rb1 in a Mouse Model of Allergic Asthma Through Relegating Th1/Th2. Inflammation. 2015 Oct;38(5):1814-22.

[3]Cao J, Zheng YQ, Liu TP, Feng LZ. Inhibitory effects of ginsenoside Rg1 and Rb1 on rat brain microsomal Na+,K(+)-ATPase activity. Zhongguo Yao Li Xue Bao. 1990 Jan;11(1):10-4

[4]Zhou P, Xie W, He S, Sun Y, Meng X, Sun G, Sun X. Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis. Cells. 2019 Feb 28;8(3):204

[5]Zhou P, Zhang X, Guo M, Guo R, Wang L, Zhang Z, Lin Z, Dong M, Dai H, Ji X, Lu H. Ginsenoside Rb1 ameliorates CKD-associated vascular calcification by inhibiting the Wnt/β-catenin pathway. J Cell Mol Med. 2019 Oct;23(10):7088-7098

[6]Zheng Z, Wang M, Cheng C, Liu D, Wu L, Zhu J, Qian X. Ginsenoside Rb1 reduces H2O2‑induced HUVEC dysfunction by stimulating the sirtuin‑1/AMP‑activated protein kinase pathway. Mol Med Rep. 2020 Jul;22(1):247-256

[7]Yang R, Jiang X, He X, Liang D, Sun S, Zhou G. Ginsenoside Rb1 Improves Cognitive Impairment Induced by Insulin Resistance through Cdk5/p35-NMDAR-IDE Pathway. Biomed Res Int. 2020 May 20;2020:3905719

[8]Chen C, Zhang H, Xu H, Zheng Y, Wu T, Lian Y. Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments. J Ginseng Res. 2019 Oct;43(4):499-507

 

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