Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

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CAS No. :	186763-78-0
Formula :	C₄₂H₇₀O₁₂
M.W :	767.00
SMILES Code :	C[C@@]([C@@]12C)(CC[C@@]3([H])C4(C)C)[C@@](C[C@@H](O)[C@]1([H])[C@@H](/C(C)=C/C/C=C(C)\C)CC2)([H])[C@]3(CC[C@@H]4O[C@@](O[C@H](CO)[C@@H](O)[C@@H]5O)([H])[C@@H]5O[C@]([C@@H]([C@@H](O)[C@@H]6O)O)([H])O[C@@H]6CO)C
Synonyms :	Ginsenoside Rg5
MDL No. :	MFCD22200429

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301+H311+H331
Precautionary Statements:	P501-P261-P270-P271-P264-P280-P361+P364-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405
Class:	6.1
UN#:	2811
Packing Group:	Ⅲ

HEK293T cells	300 nM	24 hours	Increased interaction between MyoD and E2A	J Ginseng Res. 2023 Nov;47(6):726-734
conventional type 1 dendritic cells (cDC1s)	50 μM	2 hours	Enhanced efferocytosis of cDC1s from SLC7A11-WT mice	J Ginseng Res. 2023 Nov;47(6):784-794
bone marrow-derived dendritic cells (BMDCs)	50 μM	48 hours	Enhanced efferocytotic capability of BMDCs from db/db mice	J Ginseng Res. 2023 Nov;47(6):784-794
SK-N-SH cells	10 μM	48 hours	To evaluate the inhibitory effect of ginsenoside Rg5 on HSV-1-induced neuroinflammation, results showed that ginsenoside Rg5 significantly inhibited inflammatory cytokine expression.	J Ginseng Res. 2024 Jul;48(4):384-394
Vero cells	10 μM	48 hours	To evaluate the inhibitory effect of ginsenoside Rg5 on HSV-1 replication, results showed that ginsenoside Rg5 significantly inhibited HSV-1 replication.	J Ginseng Res. 2024 Jul;48(4):384-394
primary pulmonary microvascular endothelial cells (PPMECs)	20 μM and 60 μM	6 hours	Ginsenoside Rg5 pretreatment significantly reduced IR-induced oxidative stress, apoptosis, and mitochondrial dysfunction.	J Ginseng Res. 2025 May;49(3):260-270
H9c2 cells	10 μM	2 hours	Rg5 promoted HK-II binding to mitochondria and inhibited Drp1 activation via Akt activation, protecting mitochondrial morphological and functional integrity.	Cell Death Dis. 2017 Feb 23;8(2):e2625
Neonatal rat ventricular myocytes (NRVMs)	10 μM	2 hours	Rg5 prevented cellular acidification by combating fatty-acid oxidation and restoring PDH activity, thereby protecting mitochondrial HK-II binding and enhancing cardiomyocyte resistance to ischemic injury.	Cell Death Dis. 2017 Feb 23;8(2):e2625
Primary myoblast cells	300 nM	72 hours	Promoted primary myoblast differentiation, increased number of fused myoblasts	J Ginseng Res. 2023 Nov;47(6):726-734
C2C12 myoblasts	100，300 nM	48 hours	Promoted C2C12 myoblast differentiation, increased expression levels of MHC, troponin-T, and myogenin	J Ginseng Res. 2023 Nov;47(6):726-734
Caco-2 cells	8 μM	2 hours	To evaluate the effects of Rg5 on the function of ABCB1 transporter, results showed that Rg5 inhibited the function of ABCB1 transporter.	J Ginseng Res. 2020 Mar;44(2):247-257
A549/T cells	2, 4, 8 μM	48 hours	To evaluate the reversal effects of Rg5 on ABCB1-mediated multidrug resistance, results showed that Rg5 significantly increased the intracellular accumulation of ABCB1 substrates, thereby reversing drug resistance.	J Ginseng Res. 2020 Mar;44(2):247-257
A2780/T cells	2, 4, 8 μM	48 hours	To evaluate the reversal effects of Rg5 on ABCB1-mediated multidrug resistance, results showed that Rg5 significantly increased the intracellular accumulation of ABCB1 substrates, thereby reversing drug resistance.	J Ginseng Res. 2020 Mar;44(2):247-257
NCI-H292 human pulmonary mucoepidermoid carcinoma cells	0, 10, 50, 100 μg/mL	2 hours	To evaluate the effect of Rg5 on MUC5AC secretion and mRNA levels. Results showed that Rg5 significantly reduced MUC5AC secretion and mRNA levels without cytotoxicity.	J Ginseng Res. 2023 Jan;47(1):97-105
HT22 cells	0 mg/mL, 20 mg/mL, 40 mg/mL	4 h pretreatment followed by 6 h thermal stress	Investigate the protective effect of Rg5 against thermal stress-induced apoptosis in HT22 cells. Results showed Rg5 inhibited p21 expression and PARP cleavage, reduced NO production, and modulated HO-1/Nrf2 signaling and cognitive-associated proteins (e.g., BDNF, GSK3β).	J Ginseng Res. 2018 Apr;42(2):225-228

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CAS No.: 186763-78-0

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CAS No.: 186763-78-0

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Product Details of Ginsenoside Rg5

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Biological Activity

Protocol

References

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Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

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ICR mice	Isoproterenol-induced cardiac ischemia model	Oral	50 mg/kg	2 consecutive days	Rg5 promoted Akt translocation to mitochondria, increased mitochondrial HK-II binding, suppressed Drp1 recruitment, and reduced cell apoptosis, thereby protecting the heart from ischemic injury.	Cell Death Dis. 2017 Feb 23;8(2):e2625
Nude mice	A549/T cell xenograft model	Intraperitoneal injection	10, 30, 50 mg/kg	Every 3 days for a total of nine injections	To evaluate the reversal effects of Rg5 on ABCB1-mediated multidrug resistance in vivo, results showed that Rg5 significantly suppressed the growth of drug-resistant tumors.	J Ginseng Res. 2020 Mar;44(2):247-257
Mice	Db/db mice (diabetic model)	Oral gavage	20 or 80 mg/kg/day	Once daily for one week	Promoted skin wound healing in diabetic mice and reduced apoptotic cells in wound areas	J Ginseng Res. 2023 Nov;47(6):784-794
Zebrafish	Zebrafish model	Water bath exposure	2.54 mg/mL	24 hours	To study the metabolic pathways and metabolites of ginsenoside Rg5 in zebrafish	J Ginseng Res. 2017 Jan;41(1):78-84
C57BL/6 mice	Radiation-induced acute lung injury model	Intraperitoneal injection	30 mg/kg/day	For 3 consecutive days	Ginsenoside Rg5 pretreatment attenuated radiation-induced acute lung damage, preserved endothelial cell junction integrity, and maintained endothelial barrier function in vivo.	J Ginseng Res. 2025 May;49(3):260-270

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	1.30mL 0.26mL 0.13mL	6.52mL 1.30mL 0.65mL	13.04mL 2.61mL 1.30mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed