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Chemical Structure| 65893-94-9 Chemical Structure| 65893-94-9

Structure of Glabrescione B
CAS No.: 65893-94-9

Chemical Structure| 65893-94-9

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Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells[1][2].

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Product Details of Glabrescione B

CAS No. :65893-94-9
Formula : C27H30O6
M.W : 450.52
SMILES Code : O=C1C(C2=CC=C(C(OCC=C(C)C)=C2)OCC=C(C)C)=COC3=CC(OC)=CC(OC)=C13

Safety of Glabrescione B

Related Pathways of Glabrescione B

Hedgehog

Isoform Comparison

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.10mL

2.22mL

1.11mL

22.20mL

4.44mL

2.22mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2
 

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