Structure of Gossypol xAcetate
CAS No.: 732279-26-4
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Gossypol-acetic acid, a polyphenolic compound isolated from the seeds of Gossypium herbaceum L., inhibits Bcl-2 by acting as a BH3 mimetic.
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| CAS No. : | 732279-26-4 |
| Formula : | C32H34O10 |
| M.W : | 578.61 |
| SMILES Code : | OC1=C(C2=C(O)C(C(C=O)=C(O)C(O)=C3C(C)C)=C3C=C2C)C(C)=CC4=C(C(C)C)C(O)=C(O)C(C=O)=C41.O=C(O)C |
| MDL No. : | MFCD00058385 |
| GHS Pictogram: |
|
| Signal Word: | Warning |
| Hazard Statements: | H302-H315-H319-H335 |
| Precautionary Statements: | P261-P305+P351+P338 |
Clinical Trial:
| NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
| NCT02938520 | HIV Infections | Phase 2 Phase 3 | Active, not recruiting | July 7, 2022 | - |
| NCT01315444 | Condition Measuring Alkaline T... More >>ide and Filling Symptoms' Questionnaire After Abrupt or Gradual Step Down Cessation of PPI Less << | Phase 1 | Withdrawn | - | - |
| NCT00244374 | Medication Adherence ... More >> Substance Abuse, Intravenous Risk Behavior Hepatitis A Hepatitis B Hepatitis C Less << | Not Applicable | Completed | - | United States, California ... More >> University of California San Francisco Medical Cen San Francisco, California, United States, 94143 0939 Less << |
| NCT00390403 | Brain and Central Nervous Syst... More >>em Tumors Less << | Phase 1 | Completed | - | United States, Alabama ... More >> Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham Birmingham, Alabama, United States, 35294 United States, Florida H. Lee Moffitt Cancer Center and Research Institute at University of South Florida Tampa, Florida, United States, 33612-9497 United States, Georgia Winship Cancer Institute of Emory University Atlanta, Georgia, United States, 30322 United States, Maryland Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore, Maryland, United States, 21231-2410 United States, Michigan Josephine Ford Cancer Center at Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, North Carolina Wake Forest University Comprehensive Cancer Center Winston-Salem, North Carolina, United States, 27157-1096 United States, Ohio Cleveland Clinic Taussig Cancer Center Cleveland, Ohio, United States, 44195 United States, Pennsylvania Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 Less << |
| NCT00244374 | - | Completed | - | - | |
| NCT00891072 | Adult Grade III Lymphomatoid G... More >>ranulomatosis Adult Nasal Type Extranodal NK/T-cell Lymphoma Contiguous Stage II Adult Burkitt Lymphoma Contiguous Stage II Adult Diffuse Large Cell Lymphoma Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma Contiguous Stage II Adult Lymphoblastic Lymphoma Contiguous Stage II Grade 1 Follicular Lymphoma Contiguous Stage II Grade 2 Follicular Lymphoma Contiguous Stage II Grade 3 Follicular Lymphoma Contiguous Stage II Mantle Cell Lymphoma Contiguous Stage II Marginal Zone Lymphoma Contiguous Stage II Small Lymphocytic Lymphoma Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue Nodal Marginal Zone B-cell Lymphoma Noncontiguous Stage II Adult Burkitt Lymphoma Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma Noncontiguous Stage II Adult Lymphoblastic Lymphoma Noncontiguous Stage II Grade 1 Follicular Lymphoma Noncontiguous Stage II Grade 2 Follicular Lymphoma Noncontiguous Stage II Grade 3 Follicular Lymphoma Noncontiguous Stage II Mantle Cell Lymphoma Noncontiguous Stage II Marginal Zone Lymphoma Noncontiguous Stage II Small Lymphocytic Lymphoma Peripheral T-cell Lymphoma Recurrent Adult Burkitt Lymphoma Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Adult Diffuse Small Cleaved Cell Lymphoma Recurrent Adult Grade III Lymphomatoid Granulomatosis Recurrent Adult Immunoblastic Large Cell Lymphoma Recurrent Adult Lymphoblastic Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Recurrent Small Lymphocytic Lymphoma Splenic Marginal Zone Lymphoma Stage I Adult Burkitt Lymphoma Stage I Adult Diffuse Large Cell Lymphoma Stage I Adult Diffuse Mixed Cell Lymphoma Stage I Adult Diffuse Small Cleaved Cell Lymphoma Stage I Adult Immunoblastic Large Cell Lymphoma Stage I Adult Lymphoblastic Lymphoma Stage I Grade 1 Follicular Lymphoma Stage I Grade 2 Follicular Lymphoma Stage I Grade 3 Follicular Lymphoma Stage I Mantle Cell Lymphoma Stage I Marginal Zone Lymphoma Stage I Small Lymphocytic Lymphoma Stage III Adult Burkitt Lymphoma Stage III Adult Diffuse Large Cell Lymphoma Stage III Adult Diffuse Mixed Cell Lymphoma Stage III Adult Diffuse Small Cleaved Cell Lymphoma Stage III Adult Immunoblastic Large Cell Lymphoma Stage III Adult Lymphoblastic Lymphoma Stage III Grade 1 Follicular Lymphoma Stage III Grade 2 Follicular Lymphoma Stage III Grade 3 Follicular Lymphoma Stage III Mantle Cell Lymphoma Stage III Marginal Zone Lymphoma Stage III Small Lymphocytic Lymphoma Stage IV Adult Burkitt Lymphoma Stage IV Adult Diffuse Large Cell Lymphoma Stage IV Adult Diffuse Mixed Cell Lymphoma Stage IV Adult Diffuse Small Cleaved Cell Lymphoma Stage IV Adult Immunoblastic Large Cell Lymphoma Stage IV Adult Lymphoblastic Lymphoma Stage IV Grade 1 Follicular Lymphoma Stage IV Grade 2 Follicular Lymphoma Stage IV Grade 3 Follicular Lymphoma Stage IV Mantle Cell Lymphoma Stage IV Marginal Zone Lymphoma Stage IV Small Lymphocytic Lymphoma Unspecified Adult Solid Tumor, Protocol Specific Waldenstr?m Macroglobulinemia Less << | Phase 1 | Completed | - | United States, New Jersey ... More >> Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 Less << |
| NCT00286806 | Hormone Refractory Prostate Ca... More >>ncer Less << | Phase 1 Phase 2 | Completed | - | United States, California ... More >> Greenbrae, California, United States United States, Connecticut New Haven, Connecticut, United States United States, Tennessee Memphis, Tennessee, United States United States, Wisconsin Madison, Wisconsin, United States Less << |
| NCT03685084 | Healthy | Phase 1 | Completed | - | - |
| NCT01633541 | Laryngeal Cancer | Phase 2 | Active, not recruiting | December 2018 | United States, Michigan ... More >> University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 Less << |
| NCT00275431 | Follicular Lymphoma ... More >> Diffuse Large Cell Lymphoma Mantle Cell Lymphoma Small Lymphocytic Lymphoma Chronic Lymphocytic Leukemia Less << | Phase 2 | Completed | - | United States, Alabama ... More >> Birmingham, Alabama, United States United States, California San Diego, California, United States United States, Georgia Atlanta, Georgia, United States United States, Illinois Chicago, Illinois, United States United States, Massachusetts Boston, Massachusetts, United States United States, New York New York, New York, United States Rochester, New York, United States United States, North Carolina High Point, North Carolina, United States United States, South Carolina Hilton Head Island, South Carolina, United States United States, Tennessee Memphis, Tennessee, United States United States, Vermont Burlington, Vermont, United States Less << |
| NCT01265199 | Acute Myelogenous Leukemia (AM... More >>L) Less << | Phase 1 | Terminated(Study was terminate... More >>d before a MTD was determined for administrative reasons) Less << | - | United States, Illinois ... More >> Univerity of Chicago Chicago, Illinois, United States United States, Michigan University of Michigan Health System Ann Arbor, Michigan, United States United States, Missouri Washington University at St. Louis Siteman Cancer Center St. Louis, Missouri, United States United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States United States, Pennsylvania Hospital of the University of Pennsylvania Philadelphia, Pennsylvania, United States Temple University at Jeanes Hospital Philadelphia, Pennsylvania, United States Less << |
| NCT00440388 | Follicular Lymphoma | Phase 2 | Completed | - | - |
| NCT01285635 | Squamous Cell Carcinoma of the... More >> Head and Neck (SCCHN) Less << | Phase 2 | Terminated(drug is no longer m... More >>anufactured) Less << | - | United States, Michigan ... More >> University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 Barbara Ann Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Less << |
| NCT00397293 | Small Cell Lung Cancer | Phase 1 Phase 2 | Completed | - | - |
| NCT00571675 | Hormone Refractory Prostate Ca... More >>ncer Less << | Phase 2 | Completed | - | - |
| NCT00544960 | Non-small Cell Lung Cancer | Phase 2 | Completed | - | United States, North Carolina ... More >> Research Site Durham, North Carolina, United States Russian Federation Research Site Arkhangelsk, Russian Federation Research Site Chelyabinsk, Russian Federation Research Site Ekaterinburg, Russian Federation Research Site Kaliningrad, Russian Federation Research Site Kazan, Russian Federation Research Site Moscow, Russian Federation Research Sites (4) Saint Petersburg, Russian Federation Research Site Samara, Russian Federation Research Site Stavropol, Russian Federation Research Site Voronezh, Russian Federation Ukraine Research Site Dnipropetrovsk, Ukraine Research Site Donetsk, Ukraine Research Site Kharkiv, Ukraine Research Site Kyiv, Ukraine Research Site Lugansk, Ukraine Research Site Uzhgorod, Ukraine Research Site Zaporizhzhya, Ukraine Less << |
| NCT00666666 | - | Completed | - | - | |
| NCT00666666 | Adenocarcinoma of the Prostate... More >> Stage IV Prostate Cancer Less << | Phase 2 | Completed | - | United States, Illinois ... More >> University of Chicago Chicago, Illinois, United States, 60637 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 United States, New Jersey Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Less << |
| NCT02697344 | Recurrent Plasma Cell Myeloma | Phase 1 Phase 2 | Suspended(per study design to ... More >>temporarily close) Less << | June 15, 2021 | United States, Florida ... More >> Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 Less << |
| NCT00773955 | Extensive Stage Small Cell Lun... More >>g Cancer Recurrent Small Cell Lung Cancer Less << | Phase 2 | Completed | - | United States, Minnesota ... More >> Mayo Clinic Rochester, Minnesota, United States, 55905 Less << |
| NCT00773955 | - | Completed | - | - | |
| NCT00544596 | Extensive Stage Small Cell Lun... More >>g Cancer Unspecified Adult Solid Tumor, Protocol Specific Less << | Phase 1 | Completed | - | United States, South Dakota ... More >> Sanford Cancer Center-Oncology Clinic Sioux Falls, South Dakota, United States, 57104 United States, Wisconsin Gundersen Lutheran La Crosse, Wisconsin, United States, 54601 UW Health Oncology - 1 South Park Madison, Wisconsin, United States, 53715 University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Less << |
| NCT01003769 | Recurrent Chronic Lymphocytic ... More >>Leukemia Less << | Phase 1 Phase 2 | Suspended(The accrual objectiv... More >>e for this study has not been met and is currently being re-prioritized until beacon validation sessions are completed.) Less << | June 2020 | United States, Florida ... More >> Mayo Clinic in Florida Jacksonville, Florida, United States, 32224-9980 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263 Less << |
| NCT00540722 | Adult Giant Cell Glioblastoma ... More >> Adult Glioblastoma Adult Gliosarcoma Recurrent Adult Brain Tumor Less << | Phase 2 | Completed | - | United States, Alabama ... More >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, Florida Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, Maryland Johns Hopkins University Baltimore, Maryland, United States, 21287 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Michigan Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, North Carolina Wake Forest University Health Sciences Winston-Salem, North Carolina, United States, 27157 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less << |
| NCT00540722 | - | Completed | - | - | |
| NCT00561197 | Locally Advanced Esophageal or... More >> GE Junction Cancer Less << | Phase 1 Phase 2 | Terminated(Drug not being deve... More >>loped for this indication) Less << | - | United States, Texas ... More >> MD Anderson Cancer Center Houston, Texas, United States Less << |
| NCT00286780 | Chronic Lymphocytic Leukemia | Phase 2 | Completed | - | United States, California ... More >> UCSD Moores Cancer Center San Diego, California, United States, 92093 Less << |
| NCT00988169 | - | Terminated | - | - | |
| NCT01977209 | Non-small Cell Lung Cancer | Phase 3 | Unknown | September 2016 | China, Chongqing ... More >> Daping Hospital, Third Military Medical University Recruiting Chongqing, Chongqing, China, 400042 Contact: Dong Wang, PH.D. 86-23-68757151 dongwang64@hotmail.com Principal Investigator: Dong Wang, PH.D. Chongqing Zhongshan Hospital Recruiting Chongqing, Chongqing, China Contact: Zhixiang Yang, M.D. 13032372491 Principal Investigator: Zhixiang Yang Fuling Central Hospital Recruiting Chongqing, Chongqing, China Contact: Qi Zhou, M.D. 86-23-7222676 Principal Investigator: Qi Zhou, M.D. Jiangjin Central Hospital Recruiting Chongqing, Chongqing, China Contact: Debing Xiang, M.D. 86-13320336639 Principal Investigator: Debing Xiang, M.D. The Second Affiliated Hospital of Medical University Of Chongqing Recruiting Chongqing, Chongqing, China Contact: Xianquan Zhang, M.D. 86-23-63693000 Principal Investigator: Xianquan Zhang, M.D. Three Gorges Central Hospital Recruiting Chongqing, Chongqing, China Contact: Biyong Ren 13896327099 Principal Investigator: Biyong Ren, M.D. Less << |
| NCT00286793 | Prostate Cancer | Phase 1 Phase 2 | Completed | - | United States, Arkansas ... More >> Hot Springs, Arkansas, United States United States, Florida Fort Meyers, Florida, United States United States, Illinois Chicago, Illinois, United States United States, Minnesota Fridley, Minnesota, United States United States, New Mexico Albuquerque, New Mexico, United States United States, New York Syracuse, New York, United States United States, North Carolina Wilmington, North Carolina, United States United States, Oregon Portland, Oregon, United States United States, South Carolina Hilton Head Island, South Carolina, United States United States, Tennessee Germantown, Tennessee, United States Memphis, Tennessee, United States Nashville, Tennessee, United States United States, Texas Richardson, Texas, United States Less << |
| NCT00848016 | Recurrent Adrenocortical Carci... More >>noma Stage III Adrenocortical Carcinoma Stage IV Adrenocortical Carcinoma Less << | Phase 2 | Completed | - | United States, California ... More >> University of Southern California Los Angeles, California, United States, 90033-0804 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Less << |
| NCT00848016 | - | Completed | - | - | |
| NCT01285635 | - | Terminated(drug is no longer m... More >>anufactured) Less << | - | - | |
| NCT00934076 | Carcinoma, Non Small Cell Lung | Phase 1 | Withdrawn(Study was never acti... More >>vated) Less << | June 2015 | - |
| NCT00988169 | Lung Cancer | Phase 2 | Terminated | - | United States, New York ... More >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10021 Less << |
| Bio Calculators | ||||
| Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
|
1 mM 5 mM 10 mM |
1.73mL 0.35mL 0.17mL |
8.64mL 1.73mL 0.86mL |
17.28mL 3.46mL 1.73mL |
|
Tags: Gossypol xAcetate | Bcl-2 | Apoptosis | Tumor Growth, Proliferation and Apoptosis | Parkinson'S Disease and Alzheimer'S Disease | Apoptosis | 732279-26-4
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| H260 | In contact with water releases flammable gases which may ignite spontaneously |
| H261 | In contact with water releases flammable gas |
| H270 | May cause or intensify fire; oxidizer |
| H271 | May cause fire or explosion; strong oxidizer |
| H272 | May intensify fire; oxidizer |
| H280 | Contains gas under pressure; may explode if heated |
| H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
| H290 | May be corrosive to metals |
Health hazards | |
| Code | Phrase |
| H300 | Fatal if swallowed |
| H301 | Toxic if swallowed |
| H302 | Harmful if swallowed |
| H303 | May be harmful if swallowed |
| H304 | May be fatal if swallowed and enters airways |
| H305 | May be harmful if swallowed and enters airways |
| H310 | Fatal in contact with skin |
| H311 | Toxic in contact with skin |
| H312 | Harmful in contact with skin |
| H313 | May be harmful in contact with skin |
| H314 | Causes severe skin burns and eye damage |
| H315 | Causes skin irritation |
| H316 | Causes mild skin irritation |
| H317 | May cause an allergic skin reaction |
| H318 | Causes serious eye damage |
| H319 | Causes serious eye irritation |
| H320 | Causes eye irritation |
| H330 | Fatal if inhaled |
| H331 | Toxic if inhaled |
| H332 | Harmful if inhaled |
| H333 | May be harmful if inhaled |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
| H335 | May cause respiratory irritation |
| H336 | May cause drowsiness or dizziness |
| H340 | May cause genetic defects |
| H341 | Suspected of causing genetic defects |
| H350 | May cause cancer |
| H351 | Suspected of causing cancer |
| H360 | May damage fertility or the unborn child |
| H361 | Suspected of damaging fertility or the unborn child |
| H361d | Suspected of damaging the unborn child |
| H362 | May cause harm to breast-fed children |
| H370 | Causes damage to organs |
| H371 | May cause damage to organs |
| H372 | Causes damage to organs through prolonged or repeated exposure |
| H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
| Code | Phrase |
| H400 | Very toxic to aquatic life |
| H401 | Toxic to aquatic life |
| H402 | Harmful to aquatic life |
| H410 | Very toxic to aquatic life with long-lasting effects |
| H411 | Toxic to aquatic life with long-lasting effects |
| H412 | Harmful to aquatic life with long-lasting effects |
| H413 | May cause long-lasting harmful effects to aquatic life |
| H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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