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Chemical Structure| 874119-56-9 Chemical Structure| 874119-56-9

Structure of GSK-25
CAS No.: 874119-56-9

Chemical Structure| 874119-56-9

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GSK-25 is a ROCK1 inhibitor with IC50 value of 6nM. It showed oral bioavailability (49% in rat and 19% in monkey), good half-life (1.8 h in rat and 2.2 h in monkey) and gave a robust 25 mmHg reduction mean arterial pressure in spontaneously hypertensive rats at a single dose of 30 mg/kg.

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Product Details of GSK-25

CAS No. :874119-56-9
Formula : C24H16Cl2F2N6O
M.W : 513.33
SMILES Code : O=C(C1=C(C)NC(C2=CC(Cl)=NC=C2)=NC1C3=CC=C(Cl)C=C3F)NC4=CC5=C(NN=C5)C=C4F
MDL No. :MFCD18782716
InChI Key :KZYAHEIPPAPADQ-UHFFFAOYSA-N
Pubchem ID :11548023

Safety of GSK-25

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P280-P305+P351+P338

Related Pathways of GSK-25

cytoskeleton

Isoform Comparison

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.95mL

0.39mL

0.19mL

9.74mL

1.95mL

0.97mL

19.48mL

3.90mL

1.95mL

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