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Chemical Structure| 2170137-61-6 Chemical Structure| 2170137-61-6

Structure of GSK-3685032
CAS No.: 2170137-61-6

Chemical Structure| 2170137-61-6

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GSK-3685032 is a non-time-dependent, non-covalent, reversible selective inhibitor of DNMT1 with an IC50 of 0.036 μM. GSK-3685032 induces DNA demethylation, transcriptional activation, and inhibition of cancer cell growth.

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Product Details of GSK-3685032

CAS No. :2170137-61-6
Formula : C22H24N6OS
M.W : 420.53
SMILES Code : O=C(N)C(SC1=NC(N2CCC(N)CC2)=C(C#N)C(CC)=C1C#N)C3=CC=CC=C3
MDL No. :N/A

Safety of GSK-3685032

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of GSK-3685032

epigenetics

Isoform Comparison

Biological Activity

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Mice MV4–11 and SKM-1 subcutaneous xenograft models Subcutaneous injection 1 to 45 mg/kg Twice daily for ≥4 weeks To evaluate the in vivo efficacy and tolerability of GSK3685032 in AML models PMC8594913

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.38mL

0.48mL

0.24mL

11.89mL

2.38mL

1.19mL

23.78mL

4.76mL

2.38mL

 

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