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Chemical Structure| 890842-28-1 Chemical Structure| 890842-28-1

Structure of GSK 650394
CAS No.: 890842-28-1

Chemical Structure| 890842-28-1

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GSK650394 inhibits the activities of SGK1 and SGK2 with IC50 of 62 nM and 103 nM, respectively.

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Product Details of GSK 650394

CAS No. :890842-28-1
Formula : C25H22N2O2
M.W : 382.45
SMILES Code : O=C(O)C1=CC=C(C2=CNC3=NC=C(C4=CC=CC=C4)C=C32)C=C1C5CCCC5
MDL No. :MFCD12828779
InChI Key :WVSBGSNVCDAMCF-UHFFFAOYSA-N
Pubchem ID :25022668

Safety of GSK 650394

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
A549 cells 0.78 to 100 µM 24, 48, 72, 96 hours To test the effect of GSK 650394 on the viability of A549 cells. The results showed that cells maintained good viability (≥91%) at 0.78 to 3.13 µM throughout the 96-hour period, at 6.25 to 50 µM up to 48 h (≥75%), and had poor viability (≤64%) at 100 µM. PMC3648197

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Sprague-Dawley rats Neuropathic pain model Intrathecal injection 100 nM Once daily for 7 days GSK-650394 alleviated neuropathic pain behaviors, reduced pSGK1–kalirin costaining, and attenuated SGK1–kalirin coupling. PMC6704989

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.07mL

2.61mL

1.31mL

26.15mL

5.23mL

2.61mL

References

 

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