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Chemical Structure| 801312-28-7 Chemical Structure| 801312-28-7

Structure of GSK256066
CAS No.: 801312-28-7

Chemical Structure| 801312-28-7

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GSK256066 is a selective PDE4B (equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, showing > 380,000-fold selectivity versus PDE1/2/3/5/6 and > 2500-fold selectivity against PDE4B versus PDE7.

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Product Details of GSK256066

CAS No. :801312-28-7
Formula : C27H26N4O5S
M.W : 518.58
SMILES Code : O=C(C1=C(NC2=CC=CC(OC)=C2)C3=CC(S(=O)(C4=CC=CC(C(N(C)C)=O)=C4)=O)=CC(C)=C3N=C1)N
MDL No. :MFCD18206923
InChI Key :JFHROPTYMMSOLG-UHFFFAOYSA-N
Pubchem ID :9827968

Safety of GSK256066

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Target
  • PDE4

    PDE4B, IC50:3.2 pM

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.93mL

0.39mL

0.19mL

9.64mL

1.93mL

0.96mL

19.28mL

3.86mL

1.93mL

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