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Chemical Structure| 1629013-22-4 Chemical Structure| 1629013-22-4

Structure of GSK3368715
CAS No.: 1629013-22-4

Chemical Structure| 1629013-22-4

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GSK3368715, aslo known as EPZ019997, is a potent, reversible type I PRMT inhibitor with anti-tumor effects in human cancer models. Inhibition of PRMT5, the predominant type II PRMT, produces synergistic cancer cell growth inhibition when combined with GSK3368715. Interestingly, deletion of the methylthioadenosine phosphorylase gene (MTAP) results in accumulation of the metabolite 2-methylthioadenosine, an endogenous inhibitor of PRMT5, and correlates with sensitivity to GSK3368715 in cell lines.

Synonyms: EPZ019997

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Product Details of GSK3368715

CAS No. :1629013-22-4
Formula : C20H38N4O2
M.W : 366.54
SMILES Code : CN(CCNC)CC1=CNN=C1C(CC2)CCC2(COCC)COCC
Synonyms :
EPZ019997
MDL No. :MFCD32174310

Safety of GSK3368715

Related Pathways of GSK3368715

epigenetics

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2.73mL

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2.73mL

 

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