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Chemical Structure| 264206-85-1 Chemical Structure| 264206-85-1

Structure of GSK3987
CAS No.: 264206-85-1

Chemical Structure| 264206-85-1

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GSK3987 is a broad LXRα/β agonist that promotes cholesterol efflux and triglyceride accumulation, showing potential in studies of metabolic diseases and atherosclerosis.

Synonyms: GSK3987

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Product Details of GSK3987

CAS No. :264206-85-1
Formula : C24H20N2O3
M.W : 384.43
SMILES Code : O=C(C(NC1=CC=C(OC)C=C1)=C2C3=CC=CC=C3)N(CC4=CC=CC=C4)C2=O
Synonyms :
GSK3987
MDL No. :N/A

Safety of GSK3987

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Isoform Comparison

Biological Activity

Description
GSK3987, a broad-spectrum agonist for LXRα/β, exhibits EC50s of 50 nM and 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. This compound enhances ABCA1 and SREBP-1c expression and promotes cellular cholesterol efflux while causing triglyceride accumulation[1].

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Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.60mL

0.52mL

0.26mL

13.01mL

2.60mL

1.30mL

26.01mL

5.20mL

2.60mL

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