Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

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CAS No. :	23256-50-0
Formula :	C₁₀H₁₂Cl₂N₄O₂
M.W :	291.13
SMILES Code :	ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1.CC(O)=O
Synonyms :	Wy8678 acetate; BR-750; Guanabenz(Acetate)
MDL No. :	MFCD00153801
InChI Key :	MCSPBPXATWBACD-GAYQJXMFSA-N
Pubchem ID :	5702062

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301
Precautionary Statements:	P301+P310
Class:	6.1
UN#:	2811
Packing Group:	Ⅲ

Jurkat T lymphocytes	5 or 10 µM		Suppressed PMA-induced upregulation of IL2 and IFNγ mRNA expression	PMC4881500
HeLa cells	0-200 µM	24 hours	To assess the impact of Guanabenz on HeLa cell viability, showing toxicity at concentrations of 125 µM and above.	PMC4605330
HCM-BROD-0106-C71 cells	50 μM	24 hours	To evaluate the cytotoxicity of Guanabenz on patient-derived glioblastoma cells and its combined effect with Sunitinib. Results showed that Guanabenz enhanced the cytotoxicity of Sunitinib on patient-derived glioblastoma cells.	PMC8423979
T98G-R cells	50 μM	24 hours	To evaluate the cytotoxicity of Guanabenz on TMZ-resistant glioblastoma cells and its combined effect with Sunitinib. Results showed that Guanabenz enhanced the cytotoxicity of Sunitinib on TMZ-resistant glioblastoma cells.	PMC8423979
A172 cells	50 μM	24 hours	To evaluate the cytotoxicity of Guanabenz on glioblastoma cells and its combined effect with Sunitinib. Results showed that Guanabenz enhanced the cytotoxicity of Sunitinib on glioblastoma cells and reduced Sunitinib-induced autophagy.	PMC8423979
U-87MG cells	50 μM	24 hours	To evaluate the cytotoxicity of Guanabenz on glioblastoma cells and its combined effect with Sunitinib. Results showed that Guanabenz enhanced the cytotoxicity of Sunitinib on glioblastoma cells and reduced Sunitinib-induced autophagy.	PMC8423979
DLD1 cells	50 µM	48 hours	GBZ treatment reduced the expression of β-catenin target genes	PMC8814139
U2OS cells	50 µM	overnight	GBZ treatment induced condensation of transiently expressed conductin	PMC8814139
HMC-1.1 mast cells	10 µM		Suppressed PMA-induced upregulation of TNFα and IL13 mRNA expression	PMC4881500
Human placental BeWo cell line	5 μM	24 hours	To assess the effect of GADD34 inhibition on ER stress-induced reduction in mTORC1 activity, results showed that guanabenz attenuated the tunicamycin-mediated increase in CHOP protein levels and reduction in mTORC1 activity	PMC10644500
SW480 cells	50 µM	48 hours	GBZ treatment decreased β-catenin levels, which was markedly attenuated by conductin knockout	PMC8814139
Differentiated oligodendrocyte progenitor cells (dOPCs)	5.0 μM	48 hours	Guanabenz protected dOPCs from IFN-γ-mediated apoptotic death, restoring cell survival to control levels.	PMC4360920
J774.1 cells	50 μM	6 hours	Measure mRNA expression levels of inflammatory cytokines, results showed that Guanabenz blocked LPS-induced increases in IFN-γ, TNF-α, IL-6, IL-1β, and COX-2 mRNA expression	PMC6495372
Primary macrophages	10 µM	6 hours	Suppressed LPS-induced upregulation of IL1β, IL6, TNFα, and Cox2 mRNA expression	PMC4881500
RAW264.7 macrophages	10 µM	6 hours	Suppressed LPS-induced upregulation of IL1β, IL6, TNFα, and Cox2 mRNA expression	PMC4881500
Bone marrow-derived dendritic cells	50 µM	8 hours	To evaluate the effect of GBZ on IL-10 production in LPS-stimulated dendritic cells. Results showed that GBZ increased IL-10 production.	PMC5468566

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CAS No.: 23256-50-0

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CAS No.: 23256-50-0

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Mice	MPZmutant mice and SOD1mutant mice	Oral	1 mg/kg or 5 mg/kg	Twice a day or once a day for several weeks to months	Sephin1 prevented the motor, morphological, and molecular defects of MPZmutant and SOD1mutant mice without adverse effects.	PMC4490275
BALB/c nude mice	SW480 xenograft model	Oral	50 µM	Daily for 20 days	GBZ treatment reduced tumor growth by about 60%	PMC8814139
Mice	Tsc1 conditional knockout mice	Intraperitoneal injection	8 mg/kg	Once daily from P7 to P14	To evaluate the effect of Guanabenz on oligodendrocyte survival and myelination in Tsc1 mutant mice, results showed that Guanabenz treatment partially rescued myelination defects	PMC4947172
Mice	GFAP/tTA; TRE/IFN-γ transgenic mice	Intraperitoneal injection	4 mg/kg	Daily from P7 to P18	Guanabenz protected oligodendrocytes and myelin from the detrimental effects of IFN-γ, restoring myelination to levels observed in wild type littermates.	PMC4360920
Mice (C57BL/6J)	Experimental autoimmune encephalomyelitis (EAE) model	Intraperitoneal injection	8 mg/kg	Once daily, starting from PID 7 until the end of the study	To evaluate the effect of Sephin1 on the disease progression in EAE model mice. Results showed that Sephin1 significantly delayed disease onset, reduced oligodendrocyte and axon loss, and decreased T cell presence in the CNS.	PMC6351782
NOD-SCID mice	U-87MG glioblastoma xenograft model	Peritumoral injection	10 mg/kg	3 injections on days 14, 21, and 28	To evaluate the therapeutic effect of combined treatment with Guanabenz and Sunitinib on glioblastoma xenograft model. Results showed that combined treatment significantly inhibited tumor growth, reduced Ki67 expression, and decreased autophagy-related markers.	PMC8423979
Drosophila	OPMD model	Oral	3 mM	Daily administration until adulthood	Alleviate OPMD phenotypes, including muscle degeneration and nuclear inclusion formation	PMC3044817
C57BL/6 mice	OVX-induced osteoporosis model	Intraperitoneal injection	4, 8 mg/kg	Every two days for 6 weeks	Inhibition of OVX-induced osteoporosis	PMC10943029
C57BL/6 mice	Tunicamycin-induced ER stress model	Intraperitoneal injection	4 mg/kg	For 3 consecutive days	Sephin1 significantly suppressed tunicamycin-induced renal tubular cell death, improved survival, and markedly suppressed nuclear translocation of CHOP.	PMC11840111
BALB/cJ and C57BL/6J mice	Chronic Toxoplasma infection model	Intraperitoneal injection	5 mg/kg	Once daily for 3 to 6 weeks	Evaluate the effects of Guanabenz on brain cyst burden and neuroinflammation in chronically Toxoplasma-infected mice. Results showed that Guanabenz significantly reduced brain cyst burden (~75%) in BALB/cJ mice via i.p. injection and reversed Toxoplasma-induced hyperactivity, which correlated with reduced neuroinflammation. However, in C57BL/6J mice, Guanabenz increased cyst burden but still reversed hyperactivity.	PMC6495372
BALB/cJ and C57BL/6J mice	Chronic Toxoplasma infection model	Oral gavage	10 mg/kg	Once daily for 3 to 6 weeks	Evaluate the effects of Guanabenz on brain cyst burden and neuroinflammation in chronically Toxoplasma-infected mice. Results showed that Guanabenz significantly reduced brain cyst burden (~75%) in BALB/cJ mice via i.p. injection and reversed Toxoplasma-induced hyperactivity, which correlated with reduced neuroinflammation. However, in C57BL/6J mice, Guanabenz increased cyst burden but still reversed hyperactivity.	PMC6495372
C57BL/6 mice	D-galactosamine/LPS-induced liver damage model	Intraperitoneal injection	2 mg/kg	Single injection, observed for 48 hours	To evaluate the effect of GBZ on d-galN/LPS-induced liver damage and mortality. Results showed that GBZ significantly improved Mice survival, reduced liver damage, increased IL-10 levels, and inhibited TNF-α production.	PMC5468566
C57BL/6 mice	G93A mtSOD1 transgenic mice	Intraperitoneal injection	8 mg/kg	Three times a week starting at 60 days of age	Guanabenz significantly delayed disease onset, prolonged the duration of the early phase of disease, and extended survival of G93A mice.	PMC4179984

NCT02423083	Multiple Sclerosis, Relapsing-... More >>Remitting Multiple Sclerosis Less <<	Phase 1	Terminated	-	United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
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NCT02443103	-		Terminated(Slow accrual)	-	-

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed